The relationship between nutrient feed rate and specific growth rate in fed batch cultures

1977 ◽  
Vol 4 (2) ◽  
pp. 87-92 ◽  
Author(s):  
R. C. Jones ◽  
R. M. Anthony
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Feed Rate ◽  
Specific Growth ◽  
Fed Batch ◽  
Batch Cultures ◽  
The Relationship ◽  
Nutrient Feed

Influence of specific growth rate over the secretory expression of recombinant potato carboxypeptidase inhibitor in fed-batch cultures of Escherichia coli

2010 ◽  
Vol 45 (8) ◽  
pp. 1334-1341 ◽  
Author(s):  
Juan-Miguel Puertas ◽  
Jordi Ruiz ◽  
Mónica Rodríguez de la Vega ◽  
Julia Lorenzo ◽  
Glòria Caminal ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Growth Rate ◽  
Specific Growth Rate ◽  
Specific Growth ◽  
Fed Batch ◽  
Secretory Expression ◽  
Batch Cultures ◽  
Carboxypeptidase Inhibitor

scholarly journals Control of Specific Growth Rate in Fed-Batch Bioprocesses: Novel Controller Design for Improved Noise Management

Processes ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. 679 ◽  
Author(s):  
Yann Brignoli ◽  
Brian Freeland ◽  
David Cunningham ◽  
Michal Dabros
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Real Time ◽  
Specific Growth ◽  
Controller Design ◽  
Control Variable ◽  
Biomass Concentration ◽  
Growth Dynamics ◽  
Fed Batch ◽  
Batch Cultures

Accurate control of the specific growth rate (µ) of microorganisms is dependent on the ability to quantify the evolution of biomass reliably in real time. Biomass concentration can be monitored online using various tools and methods, but the obtained signal is often very noisy and unstable, leading to inaccuracies in the estimation of μ. Furthermore, controlling the growth rate is challenging as the process evolves nonlinearly and is subject to unpredictable disturbances originating from the culture’s metabolism. In this work, a novel feedforward-feedback controller logic is presented to counter the problem of noise and oscillations in the control variable and to address the exponential growth dynamics more effectively. The controller was tested on fed-batch cultures of Kluyveromyces marxianus, during which μ was estimated in real time from online biomass concentration measurements obtained with dielectric spectroscopy. It is shown that the specific growth rate can be maintained at different setpoint values with an average root mean square control error of 23 ± 6%.

The relationship between specific growth rate and swimming performance in male fathead minnows (Pimephales promelas)

1995 ◽  
Vol 73 (11) ◽  
pp. 2165-2167 ◽  
Author(s):  
Alan S. Kolok ◽  
James T. Oris
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Swimming Speed ◽  
Specific Growth ◽  
Swimming Performance ◽  
Pimephales Promelas ◽  
Significant Negative Correlation ◽  
Fathead Minnows ◽  
Critical Swimming Speed ◽  
The Relationship

The objective of this study was to test the hypothesis that the specific growth rate of male fathead minnows (Pimephales promelas) was positively correlated with swimming performance. Subadult fish were allowed to grow into adults over a period of 31 – 55 days, after which the critical swimming speed of each fish was determined. Variation in critical swimming speed was substantial (greater than 50%), and a significant positive correlation was found between number of growing days and critical swimming speed, whereas a significant negative correlation was found between specific growth rate and critical swimming speed. A multiple regression using specific growth rate and number of growing days explained over 47% of the variation in swimming performance. Fathead minnows that grow fast are poor swimmers, suggesting a trade-off between swimming performance and specific growth rate in this species.

An algorithm for operating a fed-batch fermentor at optimum specific-growth rate

1989 ◽  
Vol 33 (1) ◽  
pp. 115-125 ◽  
Author(s):  
Pramod Agrawal ◽  
George Koshy ◽  
Michael Ramseier
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Specific Growth ◽  
Fed Batch

scholarly journals Specific Growth Rate control in Fed-Batch Bakers' Yeast Fermentation

1993 ◽  
Vol 26 (2) ◽  
pp. 185-188
Author(s):  
M. Keulers ◽  
L. Ariaans ◽  
M. Giuseppin ◽  
R. Soeterboek
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Rate Control ◽  
Specific Growth ◽  
Yeast Fermentation ◽  
Fed Batch ◽  
Growth Rate Control
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