The possible role of clays in prebiotic peptide synthesis

1974 ◽  
Vol 5 (1-2) ◽  
pp. 173-187 ◽  
Author(s):  
Mella Paecht-Horowitz
Keyword(s):  
Peptide Synthesis ◽  
Prebiotic Peptide Synthesis

scholarly journals Role of capping in peptide synthesis

2020 ◽  
Vol 11 (4) ◽  
pp. 5225-5228
Author(s):  
Deepshikha Verma ◽  
Pillai V N R ◽  
Giriraj Tailor
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Protecting Groups ◽  
Amino Groups ◽  
Peptide Chemistry ◽  
Fmoc Spps ◽  
Reliable Methods ◽  
Important Test

Protecting groups like Fmoc and coupling both steps are essential to monitoring the Fmoc SPPS (Solid Phase Peptide Synthesis) reaction completion. Reliable methods are used to detect the unreacted number of amino groups for monitoring these two essential reaction steps of coupling and cleavage. The ability to detect the complete coupling, incomplete coupling or failure of coupling we use many colour tests in the laboratory and based on this the Fmoc peptide chemistry allows the control of the completion of the Fmoc cleavage. The most important test used is the Kaiser test and highly recommended to monitor the coupling and cleavage steps. If the result of colour tests is positive after coupling, then the second coupling should be performed. Then again use the colour test to detect the level of coupling. If the result is still slightly positive, repeat coupling with the smaller modification of reagents such as used PyBOP instead of HOBT AND HOAT. These colour tests help in revealing the presence of unreacted amino-functional groups. Thus, we need to block these free N-terminal of amino- acids which help in avoiding the making of deletion of sequence.

A plausible model correlates prebiotic peptide synthesis with the primordial genetic code

2018 ◽  
Vol 54 (62) ◽  
pp. 8598-8601 ◽  
Author(s):  
Jianxi Ying ◽  
Songsen Fu ◽  
Xin Li ◽  
Liubin Feng ◽  
Pengxiang Xu ◽  
...  
Keyword(s):  
Genetic Code ◽  
Peptide Synthesis ◽  
Plausible Model ◽  
Primordial Genetic Code ◽  
Prebiotic Peptide Synthesis

The analogs of 5′-aa-AMPs, namely nucleotide amidates (aa-N-NMPs), obtained under Hadean conditions. B = base.

Trimetaphosphate and imidazole—Possible reagents in prebiotic peptide synthesis

2016 ◽  
Vol 191 (11-12) ◽  
pp. 1558-1559 ◽  
Author(s):  
Nikita Yu. Serov ◽  
Valery G. Shtyrlin ◽  
Khasan R. Khayarov
Keyword(s):  
Peptide Synthesis ◽  
Prebiotic Peptide Synthesis
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