T-lymphocyte activation in IgA nephropathy: Serum-soluble interleukin 2 receptor level, interleukin 2 production, and interleukin 2 receptor expression by cultured lymphocytes

1989 ◽  
Vol 9 (6) ◽  
pp. 485-492 ◽  
Author(s):  
Kar Neng Lai ◽  
Joseph C. K. Leung ◽  
Fernand Mac-Moune Lai ◽  
John S. Tam
Keyword(s):  
Iga Nephropathy ◽  
T Lymphocyte ◽  
Interleukin 2 ◽  
Lymphocyte Activation ◽  
Receptor Expression ◽  
Receptor Level ◽  
Interleukin 2 Receptor ◽  
T Lymphocyte Activation ◽  
Soluble Interleukin 2 Receptor

T lymphocyte activation in euthyroid Graves' ophthalmopathy: soluble interleukin 2 receptor release, cellular interleukin 2 receptor expression and interleukin 2 production

1989 ◽  
Vol 120 (5) ◽  
pp. 602-609 ◽  
Author(s):  
Kar Neng Lai ◽  
Joseph C. K. Leung ◽  
Chun Chung Chow ◽  
Clive S. Cockram
Keyword(s):  
T Lymphocyte ◽  
Interleukin 2 ◽  
Lymphocyte Activation ◽  
Receptor Expression ◽  
Pokeweed Mitogen ◽  
Healthy Controls ◽  
Interleukin 2 Receptor ◽  
T Lymphocyte Activation ◽  
Graves Ophthalmopathy ◽  
Soluble Interleukin 2 Receptor

Abstract. The present study was undertaken to examine the cellular control arm of the immune response with regard to T lymphocyte proliferation in euthyroid Graves' ophthalmopathy. Twenty patients with euthyroid Graves' ophthalmopathy (7 on antithyroid drugs and 13 on no treatment) and 18 healthy controls were studied in an infection-free period. Mitogen-stimulated cellular interleukin 2 (IL2) receptor expression, soluble interleukin 2 receptor release, and interleukin 2 production, were studied in peripheral blood mononuclear cells cultured for 24 h. The cellular IL2 receptor expression and soluble IL2 receptor release did not differ between the patients and healthy controls. In contrast, IL2 production in response to pokeweed mitogen stimulation was increased in lymphocytes from patients with Graves' ophthalmopathy. The IL2 release did not correlate with the quantities of cellular and soluble IL2 receptor. The mitogen-stimulated cellular IL2 receptor expression, IL2 receptor release, and IL2 production did not differ between patients with or without carbimazole therapy. Despite a suggested role of autoreactive T cells in mediating the development and propagation of autoimmune thyroid disease, this study fails to demonstrate a defective T lymphocyte activation state in patients with Graves' ophthalmopathy during an euthyroid state.

Pretreatment serum soluble interleukin-2 receptor level predicts survival in patients with newly diagnosed follicular lymphoma

2020 ◽  
Vol 61 (9) ◽  
pp. 2113-2121
Author(s):  
Kenji Nozaki ◽  
Hiroyuki Sugahara ◽  
Shuji Ueda ◽  
Jun Ishikawa ◽  
Shigeo Fuji ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Interleukin 2 ◽  
Newly Diagnosed ◽  
Receptor Level ◽  
Interleukin 2 Receptor ◽  
Soluble Interleukin 2 Receptor ◽  
Pretreatment Serum

scholarly journals Correlation Between Thymoma and Soluble Interleukin-2 Receptor Expression in a Patient with Good Syndrome

2021 ◽  
Vol Volume 14 ◽  
pp. 5045-5049
Author(s):  
Haruka Kitano ◽  
Fumihiro Yamaguchi ◽  
Kenji Atarashi ◽  
Mina Hiraiwa ◽  
Yo Shiratori ◽  
...  
Keyword(s):  
Interleukin 2 ◽  
Receptor Expression ◽  
Interleukin 2 Receptor ◽  
Good Syndrome ◽  
Soluble Interleukin 2 Receptor
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