Pulmonary inflammatory responses during viral pneumonia and secondary bacterial infection

Inflammation ◽  
1983 ◽  
Vol 7 (2) ◽  
pp. 93-104 ◽  
Author(s):  
Glenn A. Warr ◽  
George J. Jakab
Keyword(s):  
Bacterial Infection ◽  
Inflammatory Responses ◽  
Viral Pneumonia ◽  
Secondary Bacterial Infection

scholarly journals EFFECT OF THE LESION DUE TO INFLUENZA VIRUS ON THE RESISTANCE OF MICE TO INHALED PNEUMOCOCCI

1949 ◽  
Vol 89 (1) ◽  
pp. 53-68 ◽  
Author(s):  
Carl G. Harford ◽  
Virginia Leidler ◽  
Mary Hara ◽  
Keyword(s):  
Influenza Virus ◽  
Bacterial Infection ◽  
Viral Pneumonia ◽  
Normal Lung ◽  
Type I ◽  
Apparent Effect ◽  
Secondary Bacterial Infection

1. The normal lung of the mouse possesses the power of reducing markedly its content of Type I pneumococci within 3 hours after inhalation of the organisms in the form of fine droplets. 2. Lungs with fully developed influenza viral pneumonia not only fail to reduce the pulmonary content of pneumococci administered in this manner but, on the contrary, support their growth. 3. After intrabronchial inoculation into mice, influenza virus multiplies rapidly in the lung within 24 hours. 4. Criteria have been established for distinction between true viral lesions of the lung and changes due to the inoculation of diluents as vehicles for the virus. 5. 24 hours after inoculation of virus, there are no macroscopic lesions in the lung and the microscopic changes are due to the diluent. 6. Presence and multiplication of the virus in the lung 24 hours after inoculation have no apparent effect on the power of the lung to reduce rapidly its content of inhaled pneumococci. 7. The effect of the virus in lowering resistance to secondary bacterial infection appears to be due to the presence of the lesion produced by the virus.

Herpetic Whitlow of the Hand in Infants

2020 ◽  
Author(s):  
Mohammad M. Al-Qattan ◽  
Nada G. AlQadri ◽  
Ghada AlHayaza
Keyword(s):  
Bacterial Infection ◽  
Case Reports ◽  
Case Series ◽  
Individual Case ◽  
Senior Author ◽  
Secondary Bacterial Infection ◽  
Clinical Appearance ◽  
History Of ◽  
Mode Of Transmission ◽  
Time Of Presentation

Abstract Introduction Herpetic whitlows in infants are rare. Previous authors only reported individual case reports. We present a case series of six infants. Materials and Methods This is a retrospective study of six cases of herpetic whitlows in infants seen by the senior author (MMA) over the past 23 years (1995–2017 inclusive). The following data were collected: age, sex, digit involved in the hand, mode of transmission, time of presentation to the author, clinical appearance, presence of secondary bacterial infection, presence of other lesions outside the hand, method of diagnosis, treatment, and outcome. Results All six infants initially presented with classic multiple vesicles of the digital pulp. In all cases, there was a history of active herpes labialis in the mother. Incision and drainage or deroofing of the vesicles (for diagnostic purposes) resulted in secondary bacterial infection. Conclusion The current report is the first series in the literature on herpetic whitlows in infants. We stress on the mode of transmission (from the mother) and establishing the diagnosis clinically. In these cases, no need for obtaining viral cultures or polymerase chain reaction; and no medications are required. Once the vesicles are disrupted, secondary bacterial infection is frequent and a combination of oral acyclovir and intravenous antibiotics will be required.

scholarly journals Inhibition of p-IκBα Ubiquitylation by Autophagy-Related Gene 7 to Regulate Inflammatory Responses to Bacterial Infection

2015 ◽  
Vol 212 (11) ◽  
pp. 1816-1826 ◽  
Author(s):  
Yan Ye ◽  
Shirui Tan ◽  
Xikun Zhou ◽  
Xuefeng Li ◽  
Michael C. Jundt ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Inflammatory Responses ◽  
Related Gene

scholarly journals Is Topical or Systemic Antimicrobial Therapy More Effective for the Treatment of Feline Acne With Secondary Bacterial Infection?

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Wendy Kwok ◽  
Kate Charlotte Mellor
Keyword(s):  
Open Access ◽  
Bacterial Infection ◽  
Antimicrobial Therapy ◽  
Systemic Treatment ◽  
Clinical Signs ◽  
Sufficient Evidence ◽  
Bottom Line ◽  
Secondary Bacterial Infection

<strong>PICO question</strong><br /><p>In cats with feline acne and secondary bacterial folliculitis or furunculosis, is topical or systemic antimicrobial therapy superior for reducing time to resolution and severity of clinical signs?</p><strong>Clinical bottom line</strong><br /><p>There is no sufficient evidence to compare topical versus systemic treatment in feline acne with secondary folliculitis/furunculosis.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

scholarly journals Prevailing role of mucosal immunoglobulins and B cells in teleost skin immune responses to bacterial infection

2020 ◽  
Author(s):  
Xiao-Ting Zhang ◽  
Yong-Yao Yu ◽  
Hao-Yue Xu ◽  
Zhen-Yu Huang ◽  
Xia Liu ◽  
...  
Keyword(s):  
B Cells ◽  
Bacterial Infection ◽  
Inflammatory Responses ◽  
The Body ◽  
Innate Immune ◽  
Flavobacterium Columnare ◽  
First Line ◽  
Skin Mucus ◽  
Skin Mucosa

AbstractThe skin of vertebrates is the outermost organ of the body and serves as the first line of defense against external aggressions. In contrast to mammalian skin, that of teleost fish lacks keratinization and has evolved to operate as a mucosal surface containing a skin-associated lymphoid tissue (SALT). Thus far, IgT representing the prevalent immunoglobulin (Ig) in SALT have only been reported upon infection with a parasite. However, very little is known about the types of B cells and Igs responding to bacterial infection in the teleost skin mucosa, as well as the inductive or effector role of the SALT in such responses. To address these questions, here we analyzed the immune response of trout skin upon infection with one of the most widespread fish skin bacterial pathogens, Flavobacterium columnare. This pathogen induced strong skin innate immune and inflammatory responses at the initial phases of infection. More critically, we found that the skin mucus of fish having survived the infection contained significant IgT-but not IgM- or IgD-specific titers against the bacteria. Moreover, we demonstrate the local proliferation and production of IgT+ B-cells and specific IgT titers respectively within the SALT upon bacterial infection. Thus, our findings represent the first demonstration that IgT is the main Ig isotype induced by the skin mucosa upon bacterial infection, and that because of the large surface of the skin, its SALT probably represents a prominent IgT inductive site in fish.

Complications of Smallpox Vaccination, 1968 Surveillance in a Comprehensive Care Clinic

PEDIATRICS ◽  
1972 ◽  
Vol 50 (3) ◽  
pp. 481-483
Author(s):  
John M. Neff ◽  
Robert H. Drachman
Keyword(s):  
Bacterial Infection ◽  
Comprehensive Care ◽  
Smallpox Vaccination ◽  
Age Group ◽  
Care Clinic ◽  
Secondary Bacterial Infection ◽  
Group 1

The records of all children who received smallpox vaccination in a large comprehensive care clinic were reviewed for complications. There were 944 vaccinations performed during 1968. Of these, 539 were primary vaccinations, 32 on children in the age group less than 1, and 517 on children in the age group 1 to 4. There were nine complications observed, all in children in the age group 1 to 4. Five of these complications were generalized erythematous urticarial eruptions, three were auto-inoculations, and one was a secondary bacterial infection at the site of vaccination.

Is There Evidence That Antibiotics Prevent Oral Infections?

PEDIATRICS ◽  
1975 ◽  
Vol 55 (2) ◽  
pp. 294-294
Author(s):  
William T. Speck
Keyword(s):  
Bacterial Infection ◽  
Secondary Infection ◽  
Secondary Bacterial Infection ◽  
Oral Infections ◽  
Herpetic Gingivostomatitis

Dr. Alan M. Polson's article on gingival and periodontal problems in children was most informative.1 However, I found the last sentence somewhat puzzling, i.e., "Antibiotics are a help in preventing secondary infection." I wonder if the author could (1) provide evidence to substantiate his suggestion that secondary bacterial infection occur with acute herpetic gingivostomatitis and (2) substantiate his claim that antibiotics prevent such a complication?

Secondary Bacterial Infection of a Solitary Cysticercus Granuloma

2020 ◽  
Vol 68 (3) ◽  
pp. 684
Author(s):  
AriGeorge Chacko ◽  
AnanthP Abraham ◽  
MandeepSingh Bindra
Keyword(s):  
Bacterial Infection ◽  
Secondary Bacterial Infection
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