Structural Changes in the central nervous system under the influence of a permanent magnetic field

1986 ◽  
Vol 102 (5) ◽  
pp. 1585-1587 ◽  
Author(s):  
M. S. Abdullakhozhdaeva ◽  
S. R. Razykov
Keyword(s):  
Magnetic Field ◽  
Central Nervous System ◽  
Nervous System ◽  
Structural Changes ◽  
Permanent Magnetic Field ◽  
The Central Nervous System

Intrathecal Magnetic Drug Targeting: A New Approach to Treating Diseases of the Central Nervous System

2013 ◽  
Author(s):  
Eric Lueshen ◽  
Indu Venugopal ◽  
Andreas Linninger
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Spinal Canal ◽  
Drug Targeting ◽  
Superparamagnetic Nanoparticles ◽  
Magnetic Drug Targeting ◽  
The Central Nervous System ◽  
Drug Doses

Intrathecal (IT) drug delivery is a standard technique which involves direct injection of drugs into the cerebrospinal fluid (CSF)-filled space within the spinal canal to treat many diseases of the central nervous system. Currently, in order to reach the therapeutic drug concentration at certain locations within the spinal canal, high drug doses are used. With no method to deliver the large drug doses locally, current IT drug delivery treatments are hindered with wide drug distributions throughout the central nervous system (CNS) which cause harmful side effects. In order to overcome the current limitations of IT drug delivery, we have developed the novel method of intrathecal magnetic drug targeting (IT-MDT). Gold-coated magnetite nanoparticles are infused into a physiologically and anatomically relevant in vitro human spine model and then targeted to a specific site using external magnetic fields, resulting in a substantial increase in therapeutic nanoparticle localization at the site of interest. Experiments aiming to determine the effect of key parameters such as magnet strength, duration of magnetic field exposure, location of magnetic field, and ferrous implants on the collection efficiency of our superparamagnetic nanoparticles in the targeting region were performed. Our experiments indicate that intrathecal magnetic drug targeting and implant-assisted IT-MDT are promising techniques for concentrating and localizing drug-functionalized nanoparticles at required target sites within the spinal canal for potential treatment of diseases affecting the central nervous system.

The Pathology of Milkiness, Thickening, and Opacity of the Pia-arachnoid in the Insane

1895 ◽  
Vol 41 (175) ◽  
pp. 622-635
Author(s):  
W. F. Robertson
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Structural Changes ◽  
Brain Cortex ◽  
Mental Disease ◽  
Waste Products ◽  
The Central Nervous System ◽  
The Subject ◽  
The Brain

There is at the present time great need of more complete and definite knowledge as to the pathology of the very marked structural changes that so commonly affect the pia-arachnoid in the insane. The subject is one of much importance to all of us as medical psychologists, for not only is the condition in question one of the most conspicuous lesions associated with mental disease, but it implicates a structure of primary importance in the economy of the central nervous system. It is by way of vessels that course through this membrane that nutriment is conveyed to the brain cortex, and the waste products resulting from metabolism in the cerebral tissues are mainly conveyed away in the fluid that circulates in its lymph spaces. Therefore it is evident that these morbid changes may very seriously interfere with the functions both of nutrition and excretion in the brain.

scholarly journals Stochastic Dosimetry for the Assessment of Children Exposure to Uniform 50 Hz Magnetic Field with Uncertain Orientation

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
E. Chiaramello ◽  
S. Fiocchi ◽  
P. Ravazzani ◽  
M. Parazzini
Keyword(s):  
Magnetic Field ◽  
Central Nervous System ◽  
Nervous System ◽  
Electric Field ◽  
Stochastic Model ◽  
Significant Difference ◽  
The Central Nervous System ◽  
Children Exposure ◽  
The Magnetic Field

This study focused on the evaluation of the exposure of children aging from five to fourteen years to 50 Hz homogenous magnetic field uncertain orientation using stochastic dosimetry. Surrogate models allowed assessing how the variation of the orientation of the magnetic field influenced the induced electric field in each tissue of the central nervous system (CNS) and in the peripheral nervous system (PNS) of children. Results showed that the electric field induced in CNS and PNS tissues of children were within the ICNIRP basic restrictions for general public and that no significant difference was found in the level of exposure of children of different ages when considering 10000 possible orientations of the magnetic field. A “mean stochastic model,” useful to estimate the level of exposure in each tissue of a representative child in the range of age from five to fourteen years, was developed. In conclusion, this study was useful to deepen knowledge about the ELF-MF exposure, including the evaluation of variable and uncertain conditions, thus representing a step towards a more realistic characterization of the exposure to EMF.

scholarly journals Experience-Associated Structural Events, Subependymal Cellular Proliferative Activity, and Functional Recovery After Injury to the Central Nervous System

2000 ◽  
Vol 20 (11) ◽  
pp. 1513-1528 ◽  
Author(s):  
Timothy Schallert ◽  
J. Leigh Leasure ◽  
Bryan Kolb
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Functional Recovery ◽  
Proliferative Activity ◽  
Structural Changes ◽  
Direct Interaction ◽  
Recovery Process ◽  
Intervention Strategies ◽  
Brain Areas ◽  
The Central Nervous System

Considerable structural plasticity is possible in the damaged neocortex and connected brain areas, and the potential for significant functional recovery remains even during the chronic phases of the recovery process. In this article, the authors review the literature on use-dependent morphologic events, focusing on the direct interaction of behavioral experience and structural changes associated with plasticity and degeneration. Experience-associated neural changes have the potential to either hinder or enhance functional recovery; therefore, issues concerning the nature, timing, and intensity of behavior-based intervention strategies are addressed.

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