Effect of repeated measurements of blood pressure on blood pressure in essential hypertension: Role of anxiety

1990 ◽  
Vol 13 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Angele McGrady ◽  
James T. Higgins
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Repeated Measurements

scholarly journals The role of home monitoring of blood pressure in evaluating the susceptibility to drugs for treatment essential hypertension

2018 ◽  
Vol 0 (1) ◽  
pp. 33-35
Author(s):  
І. С. Лисий ◽  
В. В. Саморукова ◽  
В. О. Збітнєва ◽  
О. Б. Волошина ◽  
Т. О. Дичко ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Home Monitoring

scholarly journals The Role of the Peripheral Sympathetic Nerves and the Adrenal Medulla in Maintaining Blood Pressure of Essential Hypertension

1975 ◽  
Vol 39 (5) ◽  
pp. 591-595 ◽  
Author(s):  
KEIICHIRO HONDA ◽  
SHIGERU MAEKAWA ◽  
TOYOKAZU TAMURA ◽  
SHIGEO UCHIYAMA ◽  
KENICHI SUZUKI ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Adrenal Medulla ◽  
Sympathetic Nerves

scholarly journals Gut microbiota and hypertension

2021 ◽  
Vol 26 (6) ◽  
pp. 620-628
Author(s):  
A. D. Kotrova ◽  
A. N. Shishkin ◽  
E. I. Ermolenko ◽  
D. A. Saraykina ◽  
V. A. Volovnikova
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Gut Microbiota ◽  
Blood Pressure Level ◽  
Short Chain Fatty Acids ◽  
Pressure Level ◽  
Short Chain ◽  
Salt Consumption ◽  
Based Medicine

We reviewed the composition of gut microbiota (GM) in the presence of essential hypertension by analyzing Russian and foreign research publications from the database PubMed and Electronic Research eLibrary over the last 5 years from the position of evidence-based medicine. An analytical method has been used. A literature review indicated correlations between bacteria numbers and blood pressure level. Streptococcus spp., Klebsiella spp. and also such short-chain fatty acid producers as Bifidobacterium spp., Roseburia spp. and Faecalibacterium prausnitzii were shown to have inverse and direct links with blood pressure level in patients with essential hypertension. Lactobacillus spp. take part in blood pressure regulation in case of excessive salt consumption. The recent studies confirm the role of GM in the development of essential hypertension. Certain bacterial genus and species of GM producing short-chain fatty acids require further studies.

scholarly journals A correlation between the fluctuations of cytokine concentrations measured in the morning and evening and the circadian blood pressure rhythm in patients with stage II essential hypertension

2019 ◽  
pp. 65-70 ◽  
Author(s):  
OA Radaeva ◽  
AS Simbirtsev ◽  
AV Khovryakov
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Blood Pressure Monitoring ◽  
Organ Damage ◽  
Time Of Day ◽  
Stage Ii ◽  
Healthy Controls ◽  
Cytokine Levels ◽  
Pathophysiological Role

Today, increasing attention is being paid to the role of circadian rhythms in pathology. There are time-of-day-dependent immune markers that provide valuable information about disease progression. The aim of this study was to measure evening and morning concentrations of a few cytokines (interleukins, adhesion molecules, tumor necrosis/growth factors, etc.) in the peripheral blood of patients with stage II essential hypertension and to investigate how they correlate with a nocturnal blood pressure decline. Blood samples were collected from 90 patients with stage II EH at 7:00 a.m. and 8:00 p.m. Cytokine concentrations were measured using immunoassays. Based on 24-h blood pressure monitoring, the patients were distributed into 3 groups: dippers, non-dippers and night-peakers. The morning to evening ratios of cytokine concentrations in patients with EH differed from those in healthy controls due to an increase in the evening concentrations of somnogenic cytokines (IL1β, IL1α) and LIF, sLIFr, and M-CSF whose daily fluctuations patterns remain understudied. On the whole, the fluctuation patterns of the measured cytokines in patients with stage II EH who had had the condition for 10 to 14 years and were receiving no antihypertensive treatment at the time of our study differed from those displayed by healthy controls. A twenty percent rise in the evening concentrations of IL1α, LIF, sLIFr, M-CSF, and erythropoietin contributes significantly to pathological blood pressure rhythms (as demonstrated by the groups of non-dippers and night-peakers) in patients with stage II EH receiving no antihypertensive therapy. Understanding the pathophysiological role of cytokine levels and their fluctuations over a 24-h cycle could inspire new methods for EH prevention and reduce end-organ damage.

scholarly journals Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure and Hypertension in Mice and Man

Circulation ◽  
2020 ◽  
Author(s):  
Andrii Boguslavskyi ◽  
Sergiy Tokar ◽  
Oleksandra Prysyazhna ◽  
Olena Rudyk ◽  
David Sanchez-Tatay ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Vascular Function ◽  
Vascular Tone ◽  
Regional Blood Flow ◽  
Hek Cells ◽  
The Impact

Background: Background: While it has long been recognized that smooth muscle Na/K ATPase (NKA) modulates vascular tone and blood pressure (BP), the role of its accessory protein phopholemman (PLM) has not been characterized. The aim of this study was to test the hypothesis that PLM phosphorylation regulates vascular tone in vitro and this mechanism plays an important role in modulation of vascular function and BP in experimental models in vivo and in man. Methods: Mouse studies : PLM knock-in mice (PLM 3SA ), in which PLM is rendered unphosphorylatable, were used to assess the role of PLM phosphorylation in vitro in aortic and mesenteric vessels using wire myography and membrane potential measurements. In vivo BP and regional blood flow were assessed using Doppler flow and telemetry in young (14-16 weeks) and old (57-60 weeks) wild-type (WT) and transgenic mice. Human studies : We searched human genomic databases for mutations in PLM in the region of the phosphorylation sites and performed analyses within two human data cohorts (UK Biobank and GoDARTS) to assess the impact of an identified SNP on BP. This SNP was expressed in HEK cells and its effect on PLM phosphorylation determined using Western Blotting. Results: PLM phosphorylation at Ser63 and Ser68 limited vascular constriction in response to phenylephrine. This effect was blocked by ouabain. Prevention of PLM phosphorylation in the PLM 3SA mouse profoundly enhanced vascular responses to PE both in vitro and in vivo . In ageing WT mice PLM was hypophosphorylated and this correlated with the development of ageing-induced essential hypertension. In man we identified a non-synonymous coding variant, single nucleotide polymorphism rs61753924, which causes the substitution R70C in PLM. In HEK cells the R70C mutation prevented PLM phosphorylation at Ser68. This variant's rare allele is significantly associated with increased BP in middle-aged men. Conclusions: These studies demonstrate the importance of PLM phosphorylation in the regulation of vascular tone and BP and suggest a novel mechanism, and therapeutic target, for ageing-induced essential hypertension in man.

The Role of Vascular Capacitance in the Genesis of Essential Hypertension

1976 ◽  
Vol 51 (s3) ◽  
pp. 203s-205s
Author(s):  
M. Ulrych
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Blood Volume ◽  
Plasma Renin ◽  
Disappearance Rate ◽  
Vascular Bed ◽  
Vascular Capacitance ◽  
Blood Volumes

1. Analysis of relationships between blood volume, vascular capacitance, cardiopulmonary and peripheral blood volumes, labelled albumin disappearance rate, plasma renin activity, blood pressure and age was performed in essential hypertensive males. 2. The results indicate that capacitance bed constriction probably occurs with age in essential hypertension leading to an increase in the product blood volume × vascular capacitance tone even in the presence of low blood volume. 3. A metabolic defect in the venous vascular bed along with an abnormality of regulation of renal sodium excretion is postulated.

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