scholarly journals Role of nitric oxide and prostanoids in the regulation of leg blood flow and blood pressure in humans with essential hypertension: effect of high-intensity aerobic training

2012 ◽  
Vol 590 (6) ◽  
pp. 1481-1494 ◽  
Author(s):  
Michael Nyberg ◽  
Lasse G. Jensen ◽  
Pia Thaning ◽  
Ylva Hellsten ◽  
Stefan P. Mortensen
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Blood Flow ◽  
Essential Hypertension ◽  
High Intensity ◽  
Aerobic Training ◽  
Leg Blood Flow

scholarly journals Reduced submaximal leg blood flow after high-intensity aerobic training

2001 ◽  
Vol 91 (6) ◽  
pp. 2619-2627 ◽  
Author(s):  
David N. Proctor ◽  
Jordan D. Miller ◽  
Niki M. Dietz ◽  
Christopher T. Minson ◽  
Michael J. Joyner
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Power Output ◽  
High Intensity ◽  
Aerobic Training ◽  
Muscle Blood Flow ◽  
Splanchnic Blood Flow ◽  
Active Muscle ◽  
Leg Blood Flow ◽  
Power Outputs

This study evaluated the hypothesis that active muscle blood flow is lower during exercise at a given submaximal power output after aerobic conditioning as a result of unchanged cardiac output and blunted splanchnic vasoconstriction. Eight untrained subjects (4 men, 4 women, 23–31 yr) performed high-intensity aerobic training for 9–12 wk. Leg blood flow (femoral vein thermodilution), splanchnic blood flow (indocyanine green clearance), cardiac output (acetylene rebreathing), whole body O2 uptake (V˙o 2), and arterial-venous blood gases were measured before and after training at identical submaximal power outputs (70 and 140 W; upright 2-leg cycling). Training increased ( P < 0.05) peak V˙o 2(12–36%) but did not significantly change submaximalV˙o 2 or cardiac output. Leg blood flow during both submaximal power outputs averaged 18% lower after training ( P = 0.001; n = 7), but these reductions were not correlated with changes in splanchnic vasoconstriction. Submaximal leg V˙o 2 was also lower after training. These findings support the hypothesis that aerobic training reduces active muscle blood flow at a given submaximal power output. However, changes in leg and splanchnic blood flow resulting from high-intensity training may not be causally linked.

Role of Nitric Oxide on Papillary Blood Flow and Pressure Natriuresis

Hypertension ◽  
1995 ◽  
Vol 25 (3) ◽  
pp. 408-414 ◽  
Author(s):  
Francisco J. Fenoy ◽  
Paloma Ferrer ◽  
Luis Carbonell ◽  
Miguel García-Salom
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Pressure Natriuresis

Systemic and regional hemodynamics after nitric oxide synthase inhibition: role of a neurogenic mechanism

1994 ◽  
Vol 267 (1) ◽  
pp. R84-R88 ◽  
Author(s):  
M. Huang ◽  
M. L. Leblanc ◽  
R. L. Hester
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Cardiac Output ◽  
No Synthase ◽  
Before And After ◽  
Regional Hemodynamics ◽  
Autonomic Blockade ◽  
Infusion Of Norepinephrine ◽  
Oxide Synthase

The study tested the hypothesis that the increase in blood pressure and decrease in cardiac output after nitric oxide (NO) synthase inhibition with N omega-nitro-L-arginine methyl ester (L-NAME) was partially mediated by a neurogenic mechanism. Rats were anesthetized with Inactin (thiobutabarbital), and a control blood pressure was measured for 30 min. Cardiac output and tissue flows were measured with radioactive microspheres. All measurements of pressure and flows were made before and after NO synthase inhibition (20 mg/kg L-NAME) in a group of control animals and in a second group of animals in which the autonomic nervous system was blocked by 20 mg/kg hexamethonium. In this group of animals, an intravenous infusion of norepinephrine (20-140 ng/min) was used to maintain normal blood pressure. L-NAME treatment resulted in a significant increase in mean arterial pressure in both groups. L-NAME treatment decreased cardiac output approximately 50% in both the intact and autonomic blocked animals (P < 0.05). Autonomic blockade alone had no effect on tissue flows. L-NAME treatment caused a significant decrease in renal, hepatic artery, stomach, intestinal, and testicular blood flow in both groups. These results demonstrate that the increase in blood pressure and decreases in cardiac output and tissue flows after L-NAME treatment are not dependent on a neurogenic mechanism.

Mild aerobic training with blood flow restriction increases the hypertrophy index and MuSK in both slow and fast muscles of old rats: Role of PGC-1α

Life Sciences ◽  
2018 ◽  
Vol 202 ◽  
pp. 103-109 ◽  
Author(s):  
Mohammad-Ali Bahreinipour ◽  
Siyavash Joukar ◽  
Fariborz Hovanloo ◽  
Hamid Najafipour ◽  
Vida Naderi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Aerobic Training ◽  
Blood Flow Restriction ◽  
Flow Restriction ◽  
Old Rats ◽  
Fast Muscles ◽  
Slow And Fast Muscles

scholarly journals The role of nitric oxide and endothelin on optic nerve head blood flow autoregulation

2012 ◽  
Vol 13 (Suppl 1) ◽  
pp. A28
Author(s):  
Doreen Schmidl ◽  
Agnes Boltz ◽  
Semira Kaya ◽  
René Werkmeister ◽  
Reinhard Told ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head
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