Effect of mixed and separate administration of phenobarbital and 3-methylcholanthrene on benzpyrene hydroxylase in the liver of sensitive and resistant inbred mice

1980 ◽  
Vol 90 (2) ◽  
pp. 1063-1066 ◽  
Author(s):  
N. E. Polyakova ◽  
I. B. Tsyrlov ◽  
V. V. Lyakhovich
Keyword(s):  
Inbred Mice ◽  
Benzpyrene Hydroxylase

Evidence from mtDNA sequences that common laboratory strains of inbred mice are descended from a single female

Nature ◽  
1982 ◽  
Vol 295 (5845) ◽  
pp. 163-165 ◽  
Author(s):  
Stephen D. Ferris ◽  
Richard D. Sage ◽  
Allan C. Wilson
Keyword(s):  
Inbred Mice ◽  
Single Female ◽  
Mtdna Sequences ◽  
Common Laboratory

scholarly journals THE GENETICS OF SOUND INDUCED SEIZURE IN INBRED MICE

Genetics ◽  
1966 ◽  
Vol 54 (1) ◽  
pp. 95-103 ◽  
Author(s):  
K Schlesinger ◽  
R C Elston ◽  
W Boggan
Keyword(s):  
Inbred Mice

scholarly journals Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Farnaz Dabbagh Moghaddam ◽  
Iman Akbarzadeh ◽  
Ehsan Marzbankia ◽  
Mahsa Farid ◽  
Leila khaledi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Cell Lines ◽  
Encapsulation Efficiency ◽  
Inbred Mice ◽  
Breast Cancer Treatment ◽  
Anticancer Effect ◽  
Anti Cancer

Abstract Background Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer effect assessed in vitro on 4T1 and SKBR3 breast cell lines and in vivo on BALB/C inbred mice. "Thin-layer hydration method" was used for preparing the niosomes; different niosomal formulations of melittin were prepared and characterized in terms of morphology, size, polydispersity index, encapsulation efficiency, release kinetics, and stability. A niosome was formulated and loaded with melittin as a promising drug carrier system for chemotherapy of the breast cancer cells. Hemolysis, apoptosis, cell cytotoxicity, invasion and migration of selected concentrations of melittin, and melittin-loaded niosome were evaluated on 4T1 and SKBR3 cells using hemolytic activity assay, flow cytometry, MTT assay, soft agar colony assay, and wound healing assay. Real-time PCR was used to determine the gene expression. 40 BALB/c inbred mice were used; then, the histopathology, P53 immunohistochemical assay and estimate of renal and liver enzyme activity for all groups had been done. Results This study showed melittin-loaded niosome is an excellent substitute in breast cancer treatment due to enhanced targeting, encapsulation efficiency, PDI, and release rate and shows a high anticancer effect on cell lines. The melittin-loaded niosome affects the genes expression by studied cells were higher than other samples; down-regulates the expression of Bcl2, MMP2, and MMP9 genes while they up-regulate the expression of Bax, Caspase3 and Caspase9 genes. They have also enhanced the apoptosis rate and inhibited cell migration, invasion in both cell lines compared to the melittin samples. Results of histopathology showed reduce mitosis index, invasion and pleomorphism in melittin-loaded niosome. Renal and hepatic biomarker activity did not significantly differ in melittin-loaded niosome and melittin compared to healthy control. In immunohistochemistry, P53 expression did not show a significant change in all groups. Conclusions Our study successfully declares that melittin-loaded niosome had more anti-cancer effects than free melittin. This project has demonstrated that niosomes are suitable vesicle carriers for melittin, compare to the free form.

scholarly journals Studies of a Mutation Affecting Pyrimidine Degradation in Inbred Mice

1970 ◽  
Vol 245 (21) ◽  
pp. 5668-5676
Author(s):  
Yoshikazu Sanno ◽  
Mary Holzer ◽  
Robert T. Schimke
Keyword(s):  
Inbred Mice ◽  
Pyrimidine Degradation

Considerazioni e Ricerche genetistiche sul Problema degli omoinnesti

1963 ◽  
Vol 12 (2) ◽  
pp. 97-116
Author(s):  
Luigi Gedda ◽  
Ezio Gentileschi ◽  
Giorgio Gentileschi
Keyword(s):  
Lymph Nodes ◽  
Inbred Line ◽  
Skin Graft ◽  
Inbred Mice ◽  
Subsequent Stage ◽  
Subsequent Reaction ◽  
Regional Lymph Nodes ◽  
Skin Homograft ◽  
Lymphoreticular Tissue ◽  
Mz Twins

SUMMARYThe Authors describe the results obtained by their studies concerning the reaction of histocompatibility to homografts, the origin of parvicellular infiltration and regional lymphonodular modifications due to a skin graft.The acceptance or reject of a homograft in rabbit twins makes it possible to establish the presence of MZ twins. As for the parvicellular infiltration, noticed in the case of kidney homografts, according to the researches of the Authors, who have depressed the graft by means of irradiation, it may be assumed that it is originated either from the graft, or from the host.The study of regional lymph-nodes in the skin homograft in rabbit shows an evident proliferation of the lymphoreticular tissue starting in the very early days, when the graft is viable; in a subsequent stage corresponding to the graft's elimination there is a clear prevalence of plasmocytary elements in the lymphatic cords.The homograft in mice of the inbred line C57BL6shows the graft's acceptance by tissural reactions equivalent to the ones of the autograft.The homograft from random mouse on inbred mice shows the absence of a histiocytary lymphonodular reaction of the epithelioid type, which may be observed sometimes in the reaction to the allogenic homograft in the rabbit; it would be then a subsequent reaction not related to histocompatibility phenomena.

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