Evidence from mtDNA sequences that common laboratory strains of inbred mice are descended from a single female

Nature ◽  
1982 ◽  
Vol 295 (5845) ◽  
pp. 163-165 ◽  
Author(s):  
Stephen D. Ferris ◽  
Richard D. Sage ◽  
Allan C. Wilson
Keyword(s):  
Inbred Mice ◽  
Single Female ◽  
Mtdna Sequences ◽  
Common Laboratory

Comparison of Thrombelastography with Common Coagulation Tests

1981 ◽  
Vol 46 (04) ◽  
pp. 752-756 ◽  
Author(s):  
L Zuckerman ◽  
E Cohen ◽  
J P Vagher ◽  
E Woodward ◽  
J A Caprini
Keyword(s):  
Laboratory Tests ◽  
Clinical Utility ◽  
Blood Clotting ◽  
Strong Relationship ◽  
Relative Strength ◽  
Additional Information ◽  
Patients With Cancer ◽  
Two Samples ◽  
Coagulation Tests ◽  
Common Laboratory

SummaryThrombelastography, although proven as a useful research tool has not been evaluated for its clinical utility against common coagulation laboratory tests. In this study we compare the thrombelastographic measurements with six common tests (the hematocrit, platelet count, fibrinogen, prothrombin time, activated thromboplastin time and fibrin split products). For such comparisons, two samples of subjects were selected, 141 normal volunteers and 121 patients with cancer. The data was subjected to various statistical techniques such as correlation, ANOVA, canonical and discriminant analysis to measure the extent of the correlations between the two sets of variables and their relative strength to detect blood clotting abnormalities. The results indicate that, although there is a strong relationship between the thrombelastographic variables and these common laboratory tests, the thrombelastographic variables contain additional information on the hemostatic process.

Rediagnoses of the Asian genera Xylaplothrips and Mesandrothrips (Thysanoptera, Phlaeothripinae, Haplothripini), with keys to Australian species

Zootaxa ◽  
2019 ◽  
Vol 4613 (2) ◽  
pp. 327
Author(s):  
LAURENCE A. MOUND ◽  
DESLEY J. TREE
Keyword(s):  
Southeast Asia ◽  
Type Species ◽  
New Combination ◽  
New Combinations ◽  
Single Female ◽  
Australian Species ◽  
Incertae Sedis

The genus Xylaplothrips is re-diagnosed, 11 species are listed as appropriately included in this genus of which three are new combinations from Haplothrips (X. acaciae; X. collyerae; X. gahniae). A further six species are listed as incertae sedis within Xylaplothrips and a key is provided to the four species of this genus known from Australia including X. anarsius sp.n. The genus Mesandrothrips is recalled from synonymy with Xylaplothrips, and a list is provided of 20 appropriately included species of which 14 are new combinations from Xylaplothrips (M. caliginosus; M. clavipes; M. darci; M. dubius; M. emineus; M. flavitibia; M. flavus; M. inquilinus; M. montanus; M. pictipes; M. pusillus; M. reedi; M. subterraneus; M. tener), and one is a new combination from Haplothrips (M. inquinatus). A key is provided to 10 species of this genus known from Australia, including three species transferred from Haplothrips, together with M. austrosteensia sp.n., M. googongi sp.n., M. kurandae sp.n., M. lamingtoni sp.n. and M. oleariae sp.n. The type species, M. inquilinus, is widespread across Southeast Asia as an invader of thrips galls, and Haplothrips darci Girault based on a single female from Queensland is considered closely related. 

scholarly journals A new species of Ampulicomorpha Ashmead from Eocene French amber, with a list of fossil and extant Embolemidae (Insecta: Hymenoptera) of the world

2020 ◽  
Vol 191 ◽  
pp. 20
Author(s):  
Cédric Chény ◽  
Elvis Guillam ◽  
André Nel ◽  
Vincent Perrichot
Keyword(s):  
New Species ◽  
Evolutionary History ◽  
Western Europe ◽  
Distribution Map ◽  
Single Female ◽  
Fossil Species ◽  
The World ◽  
Poor Group ◽  
A New Species ◽  
Eocene Amber

Embolemidae is a cosmopolitan but species-poor group of chrysidoid wasps with a scarce fossil record, despite a long evolutionary history since at least the Early Cretaceous. Here, the new species, Ampulicomorpha quesnoyensis sp. nov., is illustrated and described based on a single female found in Early Eocene amber of Oise (France). The new species is compared with the three other known fossil species of the genus, and a key to all fossil species of Ampulicomorpha is provided. This is the third European fossil species of Ampulicomorpha, which suggests that the genus was once well established in Western Europe while it is more widely distributed in the Eastern Palaearctic region today. A list of all fossil and extant Embolemidae of the world, as well as a map of their geographical distribution map, are provided.

scholarly journals THE GENETICS OF SOUND INDUCED SEIZURE IN INBRED MICE

Genetics ◽  
1966 ◽  
Vol 54 (1) ◽  
pp. 95-103 ◽  
Author(s):  
K Schlesinger ◽  
R C Elston ◽  
W Boggan
Keyword(s):  
Inbred Mice

scholarly journals Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Farnaz Dabbagh Moghaddam ◽  
Iman Akbarzadeh ◽  
Ehsan Marzbankia ◽  
Mahsa Farid ◽  
Leila khaledi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Cell Lines ◽  
Encapsulation Efficiency ◽  
Inbred Mice ◽  
Breast Cancer Treatment ◽  
Anticancer Effect ◽  
Anti Cancer

Abstract Background Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer effect assessed in vitro on 4T1 and SKBR3 breast cell lines and in vivo on BALB/C inbred mice. "Thin-layer hydration method" was used for preparing the niosomes; different niosomal formulations of melittin were prepared and characterized in terms of morphology, size, polydispersity index, encapsulation efficiency, release kinetics, and stability. A niosome was formulated and loaded with melittin as a promising drug carrier system for chemotherapy of the breast cancer cells. Hemolysis, apoptosis, cell cytotoxicity, invasion and migration of selected concentrations of melittin, and melittin-loaded niosome were evaluated on 4T1 and SKBR3 cells using hemolytic activity assay, flow cytometry, MTT assay, soft agar colony assay, and wound healing assay. Real-time PCR was used to determine the gene expression. 40 BALB/c inbred mice were used; then, the histopathology, P53 immunohistochemical assay and estimate of renal and liver enzyme activity for all groups had been done. Results This study showed melittin-loaded niosome is an excellent substitute in breast cancer treatment due to enhanced targeting, encapsulation efficiency, PDI, and release rate and shows a high anticancer effect on cell lines. The melittin-loaded niosome affects the genes expression by studied cells were higher than other samples; down-regulates the expression of Bcl2, MMP2, and MMP9 genes while they up-regulate the expression of Bax, Caspase3 and Caspase9 genes. They have also enhanced the apoptosis rate and inhibited cell migration, invasion in both cell lines compared to the melittin samples. Results of histopathology showed reduce mitosis index, invasion and pleomorphism in melittin-loaded niosome. Renal and hepatic biomarker activity did not significantly differ in melittin-loaded niosome and melittin compared to healthy control. In immunohistochemistry, P53 expression did not show a significant change in all groups. Conclusions Our study successfully declares that melittin-loaded niosome had more anti-cancer effects than free melittin. This project has demonstrated that niosomes are suitable vesicle carriers for melittin, compare to the free form.

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