Effect of inmecarb on alcohol consumption and state of the cytochrome P-450 system of the liver at different stages of experimental alcoholism in rats

1990 ◽  
Vol 110 (3) ◽  
pp. 1227-1229
Author(s):  
G. T. Khlopushina ◽  
O. P. Kashevskaya ◽  
A. B. Kampov-Polevoi
Keyword(s):  
Alcohol Consumption ◽  
Experimental Alcoholism ◽  
Cytochrome P 450

State of the hepatic cytochrome P-450 system in rats variously predisposed to experimental alcoholism

1986 ◽  
Vol 101 (4) ◽  
pp. 449-450
Author(s):  
T. G. Khlopushina ◽  
A. B. Kampov-Polevoi ◽  
E. M. Lysenkova ◽  
O. P. Kashevskaya ◽  
I. E. Kovalev ◽  
...  
Keyword(s):  
Experimental Alcoholism ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome

Ultrastructure and Drug Metabolism in the Developing Guinea Pig

1973 ◽  
Vol 31 ◽  
pp. 538-539
Author(s):  
W. Kuenzig ◽  
M. Boublik ◽  
J.J. Kamm ◽  
J.J. Burns
Keyword(s):  
Guinea Pig ◽  
Metabolic Activity ◽  
Animal Species ◽  
Adult Animal ◽  
Smooth Endoplasmic Reticulum ◽  
Fetal Life ◽  
Mixed Function Oxidase ◽  
Cytochrome P 450 ◽  
Microsomal Mixed Function Oxidase ◽  
Mixed Function Oxidase Activity

Unlike a variety of other animal species, such as the rabbit, mouse or rat, the guinea pig has a relatively long gestation period and is a more fully developed animal at birth. Kuenzig et al. reported that drug metabolic activity which increases very slowly during fetal life, increases rapidly after birth. Hepatocytes of a 3-day old neonate metabolize drugs and reduce cytochrome P-450 at a rate comparable to that observed in the adult animal. Moreover the administration of drugs like phenobarbital to pregnant guinea pigs increases the microsomal mixed function oxidase activity already in the fetus.Drug metabolic activity is, generally, localized within the smooth endoplasmic reticulum (SER) of the hepatocyte.

Alcohol consumption patterns in heavy drinkers with and without alcoholic liver disease (ALD)

2001 ◽  
Vol 120 (5) ◽  
pp. A117-A117
Author(s):  
K DEAR ◽  
M BRADLEY ◽  
K MCCORMACK ◽  
R PECK ◽  
D GLEESON
Keyword(s):  
Liver Disease ◽  
Alcohol Consumption ◽  
Alcoholic Liver Disease ◽  
Consumption Patterns ◽  
Heavy Drinkers

Alcohol consumption and risk of heart failure in the GISSI-PREVENZIONE Study

2008 ◽  
Vol 7 ◽  
pp. 20-20
Author(s):  
G LEVANTESI ◽  
R MARFISI ◽  
M SCARANO ◽  
M SILLETTA ◽  
A MAGGIONI ◽  
...  
Keyword(s):  
Heart Failure ◽  
Alcohol Consumption
Sign in / Sign up

Export Citation Format

Share Document