State of the hepatic cytochrome P-450 system in rats variously predisposed to experimental alcoholism

1986 ◽  
Vol 101 (4) ◽  
pp. 449-450
Author(s):  
T. G. Khlopushina ◽  
A. B. Kampov-Polevoi ◽  
E. M. Lysenkova ◽  
O. P. Kashevskaya ◽  
I. E. Kovalev ◽  
...  
Keyword(s):  
Experimental Alcoholism ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome

scholarly journals Decrease in hepatic cytochrome P-450 by cobalt. Evidence for a role of cobalt protoporphyrin

1982 ◽  
Vol 204 (1) ◽  
pp. 103-109 ◽  
Author(s):  
J F Sinclair ◽  
P R Sinclair ◽  
J F Healey ◽  
E L Smith ◽  
H L Bonkowsky
Keyword(s):  
Chick Embryo ◽  
Gel Electrophoresis ◽  
Polyacrylamide Gel Electrophoresis ◽  
Polyacrylamide Gel ◽  
Cobalt Protoporphyrin ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome

Exposure of cultured chick-embryo hepatocytes to increasing concentrations of CoCl2 in the presence of allylisopropylacetamide results in formation of cobalt protoporphyrin, with a reciprocal decrease in haem and cytochrome P-450. Treatment of rats with CoCl2 (84 mumol/kg) and 5-aminolaevulinate (0.2 mmol/kg) also results in formation of cobalt protoporphyrin and a decrease in cytochrome P-450 in the liver. Hepatic microsomal fractions from rats treated with phenobarbital, CoCl2 and 5-aminolaevulinate were analysed by polyacrylamide gel electrophoresis. Cobalt protoporphyrin was associated mainly with proteins of 50000-53000 mol.wt. The results suggest that the formation of cobalt protoporphyrin occurred at the expense of the synthesis of haem, leading to a decrease in cytochrome P-450. Furthermore, the cobalt protoporphyrin that was formed may itself have been incorporated into apocytochrome P-450.

Hepatic cytochrome P-450 system in experimental hepatosplenic schistosomiasis

1987 ◽  
Vol 36 (16) ◽  
pp. 2621-2626 ◽  
Author(s):  
Mohamed El Mouelhi ◽  
Martin Black ◽  
S.Michael Phillips
Keyword(s):  
Cytochrome P 450 ◽  
Hepatosplenic Schistosomiasis ◽  
Hepatic Cytochrome

Review of Cimetidine Drug Interactions

1983 ◽  
Vol 17 (2) ◽  
pp. 110-120 ◽  
Author(s):  
Eugene M. Sorkin ◽  
Diane L. Darvey
Keyword(s):  
Blood Flow ◽  
Drug Interactions ◽  
Hepatic Blood Flow ◽  
Hepatic Clearance ◽  
Hepatic Metabolism ◽  
Rapid Onset ◽  
Related Drug ◽  
Cytochrome P 450 ◽  
Acid Labile ◽  
Hepatic Cytochrome

The literature on cimetidine drug interactions has been thoroughly reviewed. Several different mechanisms have been proposed for cimetidine-related drug interactions. These mechanisms include: (1) impaired hepatic drug metabolism due to inhibition of hepatic microsomal enzymes, (2) reduced hepatic blood flow, resulting in decreased clearance of drugs that are highly extracted by the liver, (3) increased potential for myelosuppression when administered concurrently with other drugs capable of causing myelosuppression, and (4) altered bioavailability of acid-labile drugs. Cimetidine binds reversibly to the hepatic cytochrome P-450 and P-448 systems, resulting in decreased metabolism of drugs that undergo Phase I reactions (e.g., dealkylation and hydroxylation). In contrast, glucuronidation pathways are unaffected. The rapid onset and reversal of cimetidine's inhibition of hepatic metabolism indicates an effect on hepatic enzyme systems. Cimetidine also has been reported to decrease hepatic blood flow. Drugs that are highly extracted by the liver, such as propranolol, lidocaine, and morphine, may be postulated to have a decreased hepatic clearance. Cimetidine, through its effect on gastric pH, may increase the absorption of acid-labile drugs or may decrease the absorption of drugs. There have been reports of increased potential for myelosuppression when cimetidine is administered concurrently with drugs capable of causing bone marrow suppression. An understanding of the mechanisms involved in cimetidine drug interactions allows the clinician to prevent and predict these interactions.

Delayed teratogenic effect of methylmercury on hepatic cytochrome P-450-dependent monooxygenase systems of rats

Life Sciences ◽  
1978 ◽  
Vol 22 (4) ◽  
pp. 287-294 ◽  
Author(s):  
Mark S. Robbins ◽  
John A. Hughes ◽  
Sheldon B. Sparber ◽  
Gilbert J. Mannering
Keyword(s):  
Teratogenic Effect ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome

Turnover of hepatic cytochrome P-450 in experimental cholestasis

1973 ◽  
Vol 19 (2) ◽  
pp. 241-247 ◽  
Author(s):  
Helmut Denk ◽  
Helmut Greim ◽  
Ferenc Hutterer ◽  
Fenton Schaffner ◽  
Hans Popper
Keyword(s):  
Cytochrome P 450 ◽  
Hepatic Cytochrome ◽  
Experimental Cholestasis

scholarly journals Bariatric Surgery-Induced Weight Loss Reduces Hepatic Lipid Peroxidation Levels and Affects Hepatic Cytochrome P-450 Protein Content

2010 ◽  
Vol 251 (6) ◽  
pp. 1041-1048 ◽  
Author(s):  
Lauren N. Bell ◽  
Constance J. Temm ◽  
Rashmil Saxena ◽  
Raj Vuppalanchi ◽  
Philip Schauer ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Lipid Peroxidation ◽  
Weight Loss ◽  
Protein Content ◽  
Hepatic Lipid ◽  
Hepatic Lipid Peroxidation ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome
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