Effect of repeated cold swim stress on nociceptive responses and binding of3H-naloxone to hypothalamic and midbrain opiate receptors in rats

1989 ◽  
Vol 108 (3) ◽  
pp. 1252-1254
Author(s):  
E. O. Bragin ◽  
E. V. Popkova ◽  
G. F. Vasilenko
Keyword(s):  
Opiate Receptors ◽  
Swim Stress ◽  
Nociceptive Responses

Cold water swim stress inhibits the nociceptive responses to intrathecally administered somatostatin, but not substance P

Life Sciences ◽  
1993 ◽  
Vol 52 (17) ◽  
pp. PL169-PL174 ◽  
Author(s):  
Junzo Kamei ◽  
Hideki Hitosugi ◽  
Miwa Misawa ◽  
Hiroshi Nagase ◽  
Yutaka Kasuya
Keyword(s):  
Substance P ◽  
Cold Water ◽  
Swim Stress ◽  
Nociceptive Responses

Attenuation of the habituation of neophobia by swim stress

1991 ◽  
Author(s):  
T. R. Schachtman ◽  
B. R. Butchart ◽  
J. L. Calton ◽  
S. Reilly
Keyword(s):  
Swim Stress

Effects of glucose and diabetes on binding of naloxone and dihydromorphine to opiate receptors in mouse brain

Diabetes ◽  
1987 ◽  
Vol 36 (10) ◽  
pp. 1173-1177 ◽  
Author(s):  
D. A. Brase ◽  
Y. H. Han ◽  
W. L. Dewey
Keyword(s):  
Mouse Brain ◽  
Opiate Receptors

Failure of ketamine to interact with opiate receptors

1980 ◽  
Vol 61 (4) ◽  
pp. 389-391 ◽  
Author(s):  
Walter Fratta ◽  
Mariano Casu ◽  
Angelo Balestrieri ◽  
Andrea Loviselli ◽  
Giovanni Biggio ◽  
...  
Keyword(s):  
Opiate Receptors

Phencyclidine and σ opiate receptors in brain: Biochemical and autoradiographical differentiation

1985 ◽  
Vol 113 (3) ◽  
pp. 465-466 ◽  
Author(s):  
Andrew L. Gundlach ◽  
Brian L. Largent ◽  
Solomon H. Snyder
Keyword(s):  
Opiate Receptors

scholarly journals Nociceptive Sensitization by Activation of Protease-Activated Receptor 2 in a Rat Model of Incisional Pain

2021 ◽  
Vol 11 (2) ◽  
pp. 144
Author(s):  
Kanta Kido ◽  
Norika Katagiri ◽  
Hiromasa Kawana ◽  
Shigekazu Sugino ◽  
Masanori Yamauchi ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Inflammatory Responses ◽  
Early Period ◽  
Intraplantar Injection ◽  
C Fibers ◽  
Nociceptive Responses ◽  
Incisional Pain ◽  
Protease Activated Receptor 2

Postoperative pain and consequent inflammatory responses after tissue incision adversely affects many surgical patients due to complicated mechanisms. In this study, we examined whether activation of protease-activated receptor 2 (PAR-2), which is stimulated by tryptase from mast cells, elicits nociception and whether the PAR-2 antagonist could reduce incisional nociceptive responses in vivo and in vitro. The effects of a selective PAR-2 antagonist, N3-methylbutyryl-N-6-aminohexanoyl-piperazine (ENMD-1068), pretreatment on pain behaviors were assessed after plantar incision in rats. The effects of a PAR-2 agonist, SLIGRL-NH2, on nociception was assessed after the injection into the hind paw. Furthermore, the responses of C-mechanosensitive nociceptors to the PAR-2 agonist were observed using an in vitro skin–nerve preparation as well. Intraplantar injection of SLIGRL-NH2 elicited spontaneous nociceptive behavior and hyperalgesia. Local administration of ENMD-1068 suppressed guarding behaviors, mechanical and heat hyperalgesia only within the first few hours after incision. SLIGRL-NH2 caused ongoing activity in 47% of C-mechanonociceptors in vitro. This study suggests that PAR-2 may support early nociception after incision by direct or indirect sensitization of C-fibers in rats. Moreover, PAR-2 may play a regulatory role in the early period of postoperative pain together with other co-factors to that contribute to postoperative pain.

Peripheral μ-Opiate receptors and modulation of myocardial tolerance to arrhythmogenic stimuli

1998 ◽  
Vol 125 (6) ◽  
pp. 576-578
Author(s):  
Yu. B. Lishmanov ◽  
L. N. Maslov ◽  
A. V. Krylatov
Keyword(s):  
Opiate Receptors
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