Swim stress alters hippocampal plasticity in region-specific manner: Stress-induced synaptic cross-tagging in the CA1 and excitability changes in the dentate gyrus

2011 ◽  
Author(s):  
N. B. Yeritsyan ◽  
J. U. Frey
Keyword(s):  
Dentate Gyrus ◽  
Swim Stress ◽  
Hippocampal Plasticity ◽  
Specific Manner

Reactivation of recall-induced neurons contributes to remote fear memory attenuation

Science ◽  
2018 ◽  
Vol 360 (6394) ◽  
pp. 1239-1242 ◽  
Author(s):  
Ossama Khalaf ◽  
Siegfried Resch ◽  
Lucie Dixsaut ◽  
Victoire Gorden ◽  
Liliane Glauser ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Memory Trace ◽  
Fear Memory ◽  
Memory Recall ◽  
Fear Reduction ◽  
Specific Manner ◽  
Induced Neurons ◽  
Standing Question ◽  
Memory Attenuation

Whether fear attenuation is mediated by inhibition of the original memory trace of fear with a new memory trace of safety or by updating of the original fear trace toward safety has been a long-standing question in neuroscience and psychology alike. In particular, which of the two scenarios underlies the attenuation of remote (month-old) fear memories is completely unknown, despite the impetus to better understand this process against the backdrop of enduring traumata. We found—chemogenetically and in an engram-specific manner—that effective remote fear attenuation is accompanied by the reactivation of memory recall–induced neurons in the dentate gyrus and that the continued activity of these neurons is critical for fear reduction. This suggests that the original memory trace of fear actively contributes to remote fear attenuation.

scholarly journals Regional gray matter oligodendrocyte- and myelin-related measures are associated with differential susceptibility to stress-induced behavior in rats and humans

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kimberly L. P. Long ◽  
Linda L. Chao ◽  
Yurika Kazama ◽  
Anjile An ◽  
Kelsey Y. Hu ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Gray Matter ◽  
Traumatic Stress ◽  
Brain Plasticity ◽  
Differential Susceptibility ◽  
Adult Brain ◽  
Fear Learning ◽  
Male Rats ◽  
Functional Changes ◽  
Specific Manner

AbstractIndividual reactions to traumatic stress vary dramatically, yet the biological basis of this variation remains poorly understood. Recent studies demonstrate the surprising plasticity of oligodendrocytes and myelin with stress and experience, providing a potential mechanism by which trauma induces aberrant structural and functional changes in the adult brain. In this study, we utilized a translational approach to test the hypothesis that gray matter oligodendrocytes contribute to traumatic-stress-induced behavioral variation in both rats and humans. We exposed adult, male rats to a single, severe stressor and used a multimodal approach to characterize avoidance, startle, and fear-learning behavior, as well as oligodendrocyte and myelin basic protein (MBP) content in multiple brain areas. We found that oligodendrocyte cell density and MBP were correlated with behavioral outcomes in a region-specific manner. Specifically, stress-induced avoidance positively correlated with hippocampal dentate gyrus oligodendrocytes and MBP. Viral overexpression of the oligodendrogenic factor Olig1 in the dentate gyrus was sufficient to induce an anxiety-like behavioral phenotype. In contrast, contextual fear learning positively correlated with MBP in the amygdala and spatial-processing regions of the hippocampus. In a group of trauma-exposed US veterans, T1-/T2-weighted magnetic resonance imaging estimates of hippocampal and amygdala myelin associated with symptom profiles in a region-specific manner that mirrored the findings in rats. These results demonstrate a species-independent relationship between region-specific, gray matter oligodendrocytes and differential behavioral phenotypes following traumatic stress exposure. This study suggests a novel mechanism for brain plasticity that underlies individual variance in sensitivity to traumatic stress.

scholarly journals P.1.020 Forced swim stress enhances the survival of new dentate gyrus neurons in rat through a glucocorticoid receptor-dependent mechanism

2012 ◽  
Vol 22 ◽  
pp. S29-S30
Author(s):  
K.R. Mifsud ◽  
M. Gutierrez-Mecinas ◽  
A. Collins ◽  
A.F. Trollope ◽  
S.D. Carter ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Dentate Gyrus ◽  
Swim Stress ◽  
Forced Swim ◽  
Forced Swim Stress ◽  
Dependent Mechanism

scholarly journals Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Gerardo Bernabé Ramírez-Rodríguez ◽  
María del Ángel Ocaña-Fernández ◽  
Leonardo Ortiz-López
Keyword(s):  
Dentate Gyrus ◽  
Adult Female ◽  
Control Group ◽  
Stressful Situation ◽  
Swim Stress ◽  
Environmental Stimuli ◽  
Forced Swim ◽  
Forced Swim Stress ◽  
Spatial Exploration ◽  
Newborn Neurons

Neurogenesis in the hippocampus is influenced by several factors including external stimuli. In addition to their involvement in learning and memory processes, newborn neurons of the dentate gyrus (DG) buffer against the effects of stress. Although the response of these cells to environmental stimuli has been shown, the age of the cells that respond to a brief spatial exploration or a stressful situation produced by forced-swim stress in adult female Balb/C mice is still unknown. Here, we investigated the activation of newborn neurons after three (IdU) or six weeks (CldU) postlabelling with the expression of Arc in the same mice but exposed to different environmental stimuli. Mice housed in standard conditions showed an increase in the activation of CldU-labelled cells after two exposures to a brief spatial exploration but no increase in the activation of IdU-labelled cells compared with the control group. Additionally, we analysed neuronal activation in the DG of mice housed in standard conditions and further exposed to forced-swim stress. We found a decreased activation of IdU-labelled cells in mice exposed to forced-swim stress with increase number of CldU-labelled cells. Our results suggest that based on their time postlabelling, newly generated hippocampal neurons show a different response to several environmental stimuli.

Malfunctional Reorganization in the Developing Limbo-Prefrontal System in Animals: Implications for Human Psychoses?

2001 ◽  
Vol 12 (1) ◽  
pp. 8-14
Author(s):  
Gertraud Teuchert-Noodt ◽  
Ralf R. Dawirs
Keyword(s):  
Prefrontal Cortex ◽  
Mental Disorders ◽  
Dentate Gyrus ◽  
Cognitive Functions ◽  
Experimental Approach ◽  
Regulatory Mechanisms ◽  
Hippocampal Dentate Gyrus ◽  
Non Invasive ◽  
Invasive Method ◽  
Activity Dependent

Abstract: Neuroplasticity research in connection with mental disorders has recently bridged the gap between basic neurobiology and applied neuropsychology. A non-invasive method in the gerbil (Meriones unguiculus) - the restricted versus enriched breading and the systemically applied single methamphetamine dose - offers an experimental approach to investigate psychoses. Acts of intervening affirm an activity dependent malfunctional reorganization in the prefrontal cortex and in the hippocampal dentate gyrus and reveal the dopamine position as being critical for the disruption of interactions between the areas concerned. From the extent of plasticity effects the probability and risk of psycho-cognitive development may be derived. Advance may be expected from insights into regulatory mechanisms of neurogenesis in the hippocampal dentate gyrus which is obviously to meet the necessary requirements to promote psycho-cognitive functions/malfunctions via the limbo-prefrontal circuit.

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