Dynamics of the lymph circulation and protein-cell reaction of the central lymph during the early postresuscitation period

1981 ◽  
Vol 91 (3) ◽  
pp. 282-285 ◽  
Author(s):  
M. M. Minnebaev ◽  
V. F. Bakhtiozin ◽  
M. S. Musin
Keyword(s):  
Postresuscitation Period ◽  
Cell Reaction ◽  
Lymph Circulation ◽  
Central Lymph ◽  
Protein Cell

scholarly journals Physiology and pathophysiology of the lymphatic system. Research results and further prospects

2015 ◽  
Vol 96 (1) ◽  
pp. 118-123
Author(s):  
M M Minnebaev
Keyword(s):  
Lymphatic System ◽  
Physical Stress ◽  
Lymph Flow ◽  
The Body ◽  
Diffuse Peritonitis ◽  
Circulating Blood Volume ◽  
Lymph Circulation ◽  
Filtration Barrier ◽  
Central Lymph

The review summarizes own research and literature on the role of the lymphatic system in a number of physiological and pathological conditions. The typical reaction of lymph circulation seen in shock, acute diffuse peritonitis, in postoperative period is the lymph flow volumetric rate increase. Mobilization of the lymphatic system, extravascular fluid and proteins in well-studied emergencies is explained considering the role of the lymphatic system as a natural source of circulating blood volume regulation and serum proteins replacement («autotransfusion»). These pathological processes are associated with progression of lymphatic failure on the late terms. The principle of lymph circulation targeted stimulation as a way to detoxify the body using hormones and procaine (Novocain) blockade of splanchnic nerves and the borderline sympathetic trunks was proposed based on modeled acute peritonitis. Increased microcirculation and central lymph flow, alterations in resorption, transport and filtration barrier function of the lymphatic system, as well as morphologic and functional reorganization of the lymph nodes were revealed in fever of different duration. Of particular interest are studies on the role of the lymphatic system in the immediate and long-term body adaptation to physical stress. Activation of central lymph circulation in adequate dynamic loads correlated with changes in the system lymph microcirculation (acceleration of lymph flow, increased peristalsis of the lymph microvessels walls and contractile activity of their valves). Extreme physical exhaustion was accompanied by expressed lymphovascular, extravascular and intravascular changes in the microvasculature. Lymphatic failure, as well as structural microcirculation impairments in a trained body occur only in extreme physical stress. Thus, the lymphatic system is involved in many physiological and pathological processes; its functional condition affects the course and outcome of the disease. Therefore, the treatment of the diseases requires, among other measures, correction of lymph formation and circulation (stimulation or inhibition, endolymphatic treatment, thoracic duct drainage, lymphosorption, blockade of nodal pathways and other methods - depending on the specific disease).

scholarly journals Predictors of Central Compartment Involvement in Patients with Positive Lateral Cervical Lymph Nodes according to Clinical and/or Ultrasound Evaluation

2021 ◽  
Vol 10 (15) ◽  
pp. 3407
Author(s):  
Giuseppa Graceffa ◽  
Giuseppina Orlando ◽  
Gianfranco Cocorullo ◽  
Sergio Mazzola ◽  
Irene Vitale ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Univariate Analysis ◽  
Roc Curves ◽  
Central Compartment ◽  
Central Neck Dissection ◽  
Level Of Evidence ◽  
Cervical Lymph Nodes ◽  
Kaplan Meier ◽  
Ultrasound Evaluation ◽  
Central Lymph

Lymph node neck metastases are frequent in papillary thyroid carcinoma (PTC). Current guidelines state, on a weak level of evidence, that level VI dissection is mandatory in the presence of latero-cervical metastases. The aim of our study is to evaluate predictive factors for the absence of level VI involvement despite the presence of metastases to the lateral cervical stations in PTC. Eighty-eight patients operated for PTC with level II–V metastases were retrospectively enrolled in the study. Demographics, thyroid function, autoimmunity, nodule size and site, cancer variant, multifocality, Bethesda and EU-TIRADS, number of central and lateral lymph nodes removed, number of positive lymph nodes and outcome were recorded. At univariate analysis, PTC location and number of positive lateral lymph nodes were risk criteria for failure to cure. ROC curves demonstrated the association of the number of positive lateral lymph nodes and failure to cure. On multivariate analysis, the protective factors were PTC located in lobe center and number of positive lateral lymph nodes < 4. Kaplan–Meier curves confirmed the absence of central lymph nodes as a positive prognostic factor. In the selected cases, Central Neck Dissection (CND) could be avoided even in the presence of positive Lateralcervical Lymph Nodes (LLN+).

scholarly journals Case report and literature review: Horner syndrome subsequent to endoscopic thyroid surgery

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yu Min ◽  
Hang Chen ◽  
Xing Wang ◽  
Ying Huang ◽  
Guobing Yin
Keyword(s):  
Literature Review ◽  
Thyroid Surgery ◽  
Thyroid Nodules ◽  
Rare Complication ◽  
Needle Aspiration ◽  
Horner Syndrome ◽  
Central Lymph Node Dissection ◽  
Thyroid Microcarcinoma ◽  
Endoscopic Thyroid Surgery ◽  
Central Lymph

Abstract Background Horner syndrome (HS), mainly characterized by symptoms including ptosis, miosis, and anhidrosis on the affected face, is a condition that is well documented but rarely reported as a postoperative complication of thyroidectomy, particularly in endoscopic thyroid surgery (ETS). We hereby report a case of HS due to ETS with a brief literature review on this topic. Case presentation A 31-year-old female was admitted to our hospital with an unexpected physical examination finding of two thyroid nodules that were hypoechoic, had an irregular shape, and exhibited calcification. Subsequently, the results of a fine-needle aspiration (FNA) biopsy from the thyroid nodules and BRAFV600E mutation further confirmed the malignancy of these nodules. Thus, total thyroidectomy combined with central lymph node dissection (CLND) by ETS via the bilateral axillo-breast approach was performed on this patient. Histology confirmed the diagnosis of papillary thyroid microcarcinoma (PTMC) concurrent with Hashimoto’s thyroiditis (HT). However, this patient developed HS with ptosis in her left eye on postoperative day 3. All symptoms gradually resolved before the 3-month follow-up. Conclusion HS subsequent to ETS is a rare complication. Thus, standardized and appropriate operative procedures, as well as subtle manipulation, are essential in preventing and reducing the occurrence of HS. In addition, the early diagnosis and management of this rare complication are also important for a favorable outcome.

scholarly journals MiR-489-3p inhibits cell proliferation, migration, and invasion, and induces apoptosis, by targeting the BDNF-mediated PI3K/AKT pathway in glioblastoma

2020 ◽  
Vol 15 (1) ◽  
pp. 274-283
Author(s):  
Bo Zheng ◽  
Tao Chen
Keyword(s):  
Cell Proliferation ◽  
Luciferase Reporter ◽  
Akt Pathway ◽  
Migration And Invasion ◽  
Bdnf Mrna ◽  
Protein Levels ◽  
Rna Immunoprecipitation ◽  
Underlying Mechanisms ◽  
Induced Apoptosis ◽  
Protein Cell

AbstractAmong astrocyte tumors, glioblastoma (GBM) is the most malignant glioma, highly aggressive and invasive, with extremely poor prognosis. Previous research has reported that microRNAs (miRNAs) participate in the progression of many cancers. Thus, this study aimed to explore the role and the underlying mechanisms of microRNA (miR)-489-3p in GBM progression. The expression of miR-489-3p and brain-derived neurotrophic factor (BDNF) mRNA was measured by quantitative real-time polymerase chain reaction. Western blot analysis was used to detect BDNF protein and the PI3K/AKT pathway-related protein. Cell proliferation, apoptosis, migration, and invasion were analyzed using CKK-8 assay, flow cytometry, and transwell assay, respectively. The interaction between BDNF and miR-489-3p was explored by luciferase reporter assay and RNA immunoprecipitation (RIP) assay. MiR-489-3p was down-regulated and BDNF was up-regulated in GBM tissues and cells. MiR-489-3p re-expression or BDNF knockdown inhibited GBM cell proliferation, migration, and invasion, and promoted apoptosis. BDNF was a target of miR-489-3p, and BDNF up-regulation reversed the effects of miR-489-3p on GBM cells. The protein levels of p-AKT and p-PI3K were notably reduced in GBM cells by overexpression of miR-489-3p, but were rescued following BDNF up-regulation. Therefore, miR-489-3p inhibited proliferation, migration, and invasion, and induced apoptosis, by targeting the BDNF-mediated PI3K/AKT pathway in GBM, providing new strategies for clinical treatment of GBM.

scholarly journals Low urinary iodine is a protective factor of central lymph node metastasis in papillary thyroid cancer: a cross-sectional study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Ziyang Zeng ◽  
Kang Li ◽  
Xianze Wang ◽  
Siwen Ouyang ◽  
Zimu Zhang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Protective Factor ◽  
Urinary Iodine ◽  
Iodine Intake ◽  
Clinicopathological Features ◽  
Papillary Thyroid ◽  
Central Lymph Node ◽  
High Iodine ◽  
Central Lymph

Abstract Background An abrupt increase of thyroid cancer has been witnessed paralleling the supplemented iodine intake in formerly iodine-deficient countries. And increased iodine intake has been linked to the rising incidence rate of papillary thyroid cancer (PTC). However, the correlation between iodine and clinicopathological features of PTC has not been well-characterized. This study aimed to investigate the associations between iodine intake and the clinicopathological features of PTC patients. Methods Three hundred and fifty-nine PTC patients who received surgical treatment in Peking Union Medical College Hospital from May 2015 to November 2020 were retrospectively reviewed. The associations between urinary iodine (UI), urinary iodine/creatinine ratio (UI/U-Cr), and the clinicopathological features of PTC were analyzed. Univariate and multivariate analysis were performed to investigate the relationship between UI level and central lymph node metastasis (CLNM). Results There were no significant differences in UI in different groups according to the variables studied, except that patients with CLNM had higher UI level than CLNM(−) patients. No associations were found between UI/U-Cr and clinicopathological features except variant subtypes (classic/follicular). After dividing patients into high-iodine group and low-iodine group, more patients were found to have CLNM in the high-iodine group (p = 0.02). In addition, younger age, larger tumor size, and classic variant were positively correlated with CLNM (p < 0.05). Univariate analysis showed that insufficient iodine intake (≤ 99 μg/L) was associated with decreased CLNM risk in PTC. And after defining insufficient iodine intake as ≤ 109 μg/L and above requirements as ≥ 190 μg/L, multivariate analysis showed that lower iodine was associated with CLNM in total population of PTC (OR 0.53, 95% CI 0.31–0.91) and in PTC < 1 cm (papillary thyroid microcarcinoma, PTMC) (OR 0.43, 95% CI 0.21–0.87). Conclusions Low iodine was a protective factor for CLNM in papillary thyroid cancer, particularly in those < 1 cm. These results indicated that iodine may not only be an initiator of tumorigenesis, but also a promoter of the development of PTC.

scholarly journals Clinicopathological characteristics of ypT0N0 urothelial carcinoma following neoadjuvant chemotherapy and cystectomy

2019 ◽  
Vol 72 (8) ◽  
pp. 550-553 ◽  
Author(s):  
Martin J Magers ◽  
Hristos Z Kaimakliotis ◽  
Marcelo P Barboza ◽  
Elhaam Bandali ◽  
Nabil Adra ◽  
...  
Keyword(s):  
Foreign Body ◽  
Neoadjuvant Chemotherapy ◽  
Urothelial Carcinoma ◽  
Giant Cell ◽  
Chronic Inflammation ◽  
Morphological Features ◽  
Foreign Body Giant Cell ◽  
Cell Reaction ◽  
Variant Histology

AimsTo describe a large tertiary care academic centre’s experience with patients who achieve a complete pathological response (ie, ypT0N0) following neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) with emphasis on morphological features present in the RC and clinical outcome.Methods41 patients with ypT0N0 disease following transurethral resection of bladder tumour (TURBT), NAC and RC with available clinical follow-up information were analysed. Slides from all RCs were reviewed to confirm pathological stage and assess for morphological parameters (eg, foreign body giant cell reaction, dystrophic calcification, scar and fat necrosis).ResultsWith median follow-up of 32.8 months, the recurrence-free survival at 1 and 5 years was 97.4% and 93.5%, while the overall survival at 3 and 5 years was 94.2% and 88.6%, respectively. No patients died of urothelial carcinoma. Stage assigned at TURBT was 1 pTa (2%), 1 pT1 (2%), 38 pT2 (93%) and 1 pT3a (2%). 17 TURBTs demonstrated variant histology, with the majority of these being squamous (65%). The most common morphological features present at RC were scar (100%), foreign body giant cell reaction (80%), chronic inflammation within lamina propria (68%) and dystrophic calcifications (39%). Other morphological features were less common or absent.ConclusionypT0N0 disease at RC portends an excellent prognosis, regardless of stage or variant histology in the TURBT; scar, foreign body giant cell reaction, chronic inflammation and dystrophic calcifications are often present.

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