Two levels of associative potential of acrocentric chromosomes in two chromosomal associations of human lymphocytes

1980 ◽  
Vol 89 (6) ◽  
pp. 823-825
Author(s):  
V. P. Gurbanov
Keyword(s):  
Human Lymphocytes ◽  
Acrocentric Chromosomes ◽  
Associative Potential

Essay on the nucleoli survey by the α- and β-satellite DNA probes of the acrocentric chromosomes in mitogen-stimulated human lymphocytes

2000 ◽  
Vol 43 (2) ◽  
pp. 61-68 ◽  
Author(s):  
Halil Demirtas ◽  
Zühal Candemir ◽  
Nurhan Cücer ◽  
Nalan Imamoglu ◽  
Hamiyet Dönmez ◽  
...  
Keyword(s):  
Satellite Dna ◽  
Human Lymphocytes ◽  
Dna Probes ◽  
Acrocentric Chromosomes

SATELLITE ASSOCIATION IN HUMAN LYMPHOCYTES AND SODIUM CITRATE CONCENTRATION OF HYPOTONIC (SPREADING) SOLUTION

1971 ◽  
Vol 13 (1) ◽  
pp. 115-118 ◽  
Author(s):  
Howard R. Nankin
Keyword(s):  
Sodium Citrate ◽  
Human Lymphocytes ◽  
Satellite Association ◽  
Citrate Concentration ◽  
Acrocentric Chromosomes ◽  
The Relationship

The present investigation examined the relationship between satellite association in lymphocytes and sodium citrate concentration of the hypotonic solutions used to aid in spreading chromosomes. With reduction of sodium citrate from 0.9%, to 0.75%, and to 0.6%, the percentage of acrocentric chromosomes engaged in satellite association went from 32.7%, to 26.8%, and to 19.1% respectively. The reductions appeared to be equally divided between the D group and G group chromosomes.

A role for upstream binding factor in organizing ribosomal gene chromatin

2006 ◽  
Vol 73 ◽  
pp. 77-84 ◽  
Author(s):  
Jane E. Wright ◽  
Christine Mais ◽  
José-Luis Prieto ◽  
Brian McStay
Keyword(s):  
Nucleolar Organizer ◽  
Ribosomal Gene ◽  
Rna Polymerase I ◽  
Nucleolar Organizer Regions ◽  
Binding Factor ◽  
Upstream Binding Factor ◽  
Acrocentric Chromosomes ◽  
Polymerase I ◽  
Secondary Constrictions ◽  
Active Nors

Human ribosomal genes are located in NORs (nucleolar organizer regions) on the short arms of acrocentric chromosomes. During metaphase, previously active NORs appear as prominent chromosomal features termed secondary constrictions, which are achromatic in chromosome banding and positive in silver staining. The architectural RNA polymerase I transcription factor UBF (upstream binding factor) binds extensively across the ribosomal gene repeat throughout the cell cycle. Evidence that UBF underpins NOR structure is provided by an examination of cell lines in which large arrays of a heterologous UBF binding sequences are integrated at ectopic sites on human chromosomes. These arrays efficiently recruit UBF even to sites outside the nucleolus, and during metaphase form novel silver-stainable secondary constrictions, termed pseudo-NORs, that are morphologically similar to NORs.

Potentiation of doxorubicin (DXR)'s genotoxic activities by ethanolic extract from Thai Plumbago indica roots (EEPIR) in human lymphocytes in vitro

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
T Ratanavalachai ◽  
S Thitiorul ◽  
S Tanuchit ◽  
A Itharat ◽  
I Sakpakdeejaroen
Keyword(s):  
Human Lymphocytes ◽  
Ethanolic Extract ◽  
Plumbago Indica
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