Autoradiographic study of DNA synthesis in renal tubular epithelial cells of albino rats with mercuric chloride nephrosis

1985 ◽  
Vol 100 (5) ◽  
pp. 1603-1605
Author(s):  
V. P. Andreev ◽  
A. A. Pal'tsyn
Keyword(s):  
Epithelial Cells ◽  
Dna Synthesis ◽  
Mercuric Chloride ◽  
Autoradiographic Study ◽  
Albino Rats ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Mercuric Chloride Nephrosis ◽  
Renal Tubular

Cyclosporine A induces senescence in renal tubular epithelial cells

2007 ◽  
Vol 293 (3) ◽  
pp. F831-F838 ◽  
Author(s):  
Paul Jennings ◽  
Christian Koppelstaetter ◽  
Sonia Aydin ◽  
Thomas Abberger ◽  
Anna Maria Wolf ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Epithelial Cells ◽  
Dna Synthesis ◽  
Cyclosporine A ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Proximal Tubular ◽  
Renal Tubular

The nephrotoxic potential of the widely used immunosuppressive agent cyclosporine A (CsA) is well recognized. However, the mechanism of renal tubular toxicity is not yet fully elucidated. Chronic CsA nephropathy and renal organ aging share some clinical features, such as renal fibrosis and tubular atrophy, raising the possibility that CsA may exert some of its deleterious effects via induction of a stress-induced senescent phenotype. We investigated this hypothesis in HK-2 cells and primary proximal tubular cells in vitro. CsA induced the production of H2O2, caused cell cycle arrest in the G0/G1 phase, and inhibited DNA synthesis. Furthermore, CsA exposure lead to a reduction of telomere length, increased p53 serine 15 phosphorylation, and caused an upregulation of the cell cycle inhibitor p21Kip1 (CDKN1A) mRNA levels. CsA caused an increase in p16INK4a (CDKN2A) expression after a 13-day exposure in primary proximal tubular cells but not in HK-2 cells. Coincubation of cells with CsA and catalase was able to prevent telomere shortening and partially restored DNA synthesis. In summary, CsA induces cellular senescence in human renal tubular epithelial cells, which can be attenuated by scavenging reactive oxygen species.

scholarly journals MiR-30c regulates cisplatin-induced apoptosis of renal tubular epithelial cells by targeting Bnip3L and Hspa5

2017 ◽  
Vol 8 (8) ◽  
pp. e2987-e2987 ◽  
Author(s):  
Bin Du ◽  
Xiao-meng Dai ◽  
Shuang Li ◽  
Guo-long Qi ◽  
Guang-xu Cao ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Renal Tubular ◽  
Induced Apoptosis

Cadmium and Molybdenum co-induce pyroptosis via ROS/PTEN/PI3K/AKT axis in duck renal tubular epithelial cells

2020 ◽  
pp. 116403
Author(s):  
Caiying Zhang ◽  
Tianjin Lin ◽  
Gaohui Nie ◽  
Ruiming Hu ◽  
Shaoxing Pi ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Renal Tubular
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