A study of cross-reactions between streptococcal group A antigens and fibroblasts of cardiac interstitial connective tissue from mammals of different species

1980 ◽  
Vol 89 (5) ◽  
pp. 640-642
Author(s):  
E. V. Kochetkova ◽  
I. M. Lyampert ◽  
V. Yu. Kolesnikova ◽  
E. N. Semenova
Keyword(s):  
Connective Tissue ◽  
Cross Reactions ◽  
Interstitial Connective Tissue ◽  
Group A

scholarly journals FACTORS INFLUENCING THE INTERMITTENT PASSAGE OF LOCKE'S SOLUTION INTO LIVING SKIN

1941 ◽  
Vol 73 (1) ◽  
pp. 85-108 ◽  
Author(s):  
Philip D. McMaster
Keyword(s):  
Connective Tissue ◽  
Blood Vessels ◽  
Atmospheric Pressure ◽  
Interstitial Fluid ◽  
Lymphatic Vessels ◽  
Intermittent Flow ◽  
Venous Obstruction ◽  
Factors Influencing ◽  
Interstitial Connective Tissue ◽  
Living Mouse

Minute amounts of Locke's or Tyrode's solution have been brought into contact with the interstitial connective tissue of the skin of the living mouse, at atmospheric pressure, in such a manner that the blood or lymphatic vessels are not entered directly. Under such circumstances these absorbable fluids enter the tissue spontaneously. Entrance is strikingly intermittent, not continuous, and so too when very slight pressures are brought to bear on the fluids (1). Hyperemia of the tissues, with accompanying dilatation of the blood vessels, increases the entrance of fluids at atmospheric pressure but it is still intermittent. By contrast, venous obstruction leads to intermittent backflow into the apparatus, but reflex hyperemia, following release of the obstruction, is attended by an increase of flow into the tissues in spite of the great reactive dilatation of vessels. The inflow is also intermittent. If the skin is deprived of circulation, fluid does not enter it at all at atmospheric pressure, though it moves in regularly and continuously if slight pressure is put upon it. Edema-forming fluids, described in the text, also enter in a continuous manner when forced into the skin of either living or dead animals. So too do serum and sperm oil. The findings indicate that the passage of interstitial fluid into the blood vessels may be intermittent under normal circumstances and its escape from them as well. The observed occurrence of intermittent flow in the blood vessels of several tissues (9, 15–25) will go far to account for the intermittent entrance of fluid into the skin.

scholarly journals CROSS-REACTIONS AMONG GROUP A STREPTOCOCCI

1968 ◽  
Vol 128 (5) ◽  
pp. 959-968 ◽  
Author(s):  
Grove G. Wiley ◽  
Pauline N. Bruno
Keyword(s):  
Streptococcal Infection ◽  
Cross Protection ◽  
The Other ◽  
Group A Streptococci ◽  
Agar Gel ◽  
Cross Reactions ◽  
Group A ◽  
Spur Formation ◽  
Homologous Reaction

Strains of four streptococcal types, 33, 41, 43, 52, and a nontypable strain, Ross, cross-reacted in precipitin and bactericidal tests. The homologous reactions, which determined the type, afforded the major protection and developed promptly and regularly in the serum of rabbits during immunization. The associated cross-reactions, on the other hand, appeared in the serum of certain rabbits only, were often not as strong as the associated homologous reactions, and required for their presence a longer period of immunization than the homologous reactions. Agar gel analysis of the homologous precipitin reactions revealed, as would be expected, reactions of serological identity, while those cross-reactions which were strong enough to test in this way formed bands of precipitate which joined with spur formation on the side of the homologous reaction. These experiments and others referred to in the text suggest that cross-protection, as demonstrated in bactericidal tests, is sufficiently widespread to be a factor in streptococcal immunity, if a corresponding protection occurs in vivo. Thus, streptococcal infection with one of the cross-reacting strains might confer, in addition to strong homologous protection, a certain amount of cross-protection.

scholarly journals THE SIGNIFICANCE OF M AND T ANTIGENS IN THE CROSS REACTIONS BETWEEN CERTAIN TYPES OF GROUP A HEMOLYTIC STREPTOCOCCI

1940 ◽  
Vol 71 (4) ◽  
pp. 539-550 ◽  
Author(s):  
Rebecca C. Lancefield
Keyword(s):  
Specific Antigen ◽  
Specific Protein ◽  
T Antigens ◽  
Cross Reactions ◽  
Group A ◽  
Specific Antigens ◽  
The Cross ◽  
Type 3

In any one strain the occurrence of the previously recognized type-specific protein, M, is usually completely correlated with the presence of the recently recognized type-specific antigen, T. Strain C203 is exceptional in having the T substance of type 1 as well as the two type-specific antigens, M and T, characteristic of type 3. It does not have the M antigen of type 1. While other strains with similar antigenic peculiarities have not been encountered, it is probable that they occur, and the existence of such anomalies must be suspected when unusual serological reactions occur.

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