A study of the spectrum of psychotropic action of mebicar

1980 ◽  
Vol 89 (5) ◽  
pp. 621-624 ◽  
Author(s):  
A. V. Val'dman ◽  
I. V. Zaikonnikova ◽  
M. M. Kozlovskaya ◽  
I. E. Zimakova
Keyword(s):  
Psychotropic Action

Features of the sensitivity of the central nervous system of the organism of experimental animals to the effects of certain psychotropic drugs and their combinations against the background of chronic alcohol intoxication in a chronopharmacological experiment

2020 ◽  
pp. 56-62
Author(s):  
E.V. Filippova
Keyword(s):  
Alcohol Intoxication ◽  
Laboratory Animals ◽  
Histological Structure ◽  
Chronic Alcohol ◽  
Behavioral Reactions ◽  
Experimental Animals ◽  
Chronic Alcohol Intoxication ◽  
Psychotropic Action ◽  
Adaptive Effect ◽  
The Central Nervous System

In a chronopharmacological experiment, the effect of two drugs with psychotropic action in combinations on the behavior of laboratory animals subjected to chronic alcohol intoxication was examined. Against the background of a deprimating agent, a decrease in the threshold of sensitivity to electrical irritation and the duration of an aggressive reaction was revealed; an increase in these indicators was established with a combination of a deprimating drug with an antioxidant. It has been shown that the antioxidant has a desynchronizing effect on the behavioral reactions of laboratory animals for two days, which indicates a pronounced adaptive effect. In the case of using combinations of a deprimating agent with an antioxidant, a decrease in the destruction of the histological structure of the myocardium against the background of chronic alcoholization was established.

Monoaminergic Mechanisms of Psychotropic Action of Short Peptides

1986 ◽  
pp. 203-238
Author(s):  
A. V. Valdman ◽  
M. M. Kozlovskaya ◽  
N. A. Bondarenko ◽  
V. V. Rojanetz ◽  
N. A. Avdulov ◽  
...  
Keyword(s):  
Short Peptides ◽  
Psychotropic Action ◽  
Monoaminergic Mechanisms

Anticonvulsant and psychotropic action of Tegretol(R): A preliminary report

Neurology ◽  
1966 ◽  
Vol 16 (1) ◽  
pp. 107-107 ◽  
Author(s):  
A. J. Arieff ◽  
M. Mier
Keyword(s):  
Preliminary Report ◽  
Psychotropic Action

Neurotropic and psychotropic action of estrogens

2005 ◽  
pp. 173-183 ◽  
Author(s):  
P Schönknecht ◽  
J Pantel ◽  
J Schröder ◽  
K Beyreuther
Keyword(s):  
Psychotropic Action

Analysis of neurochemical mechanisms of the psychotropic action of tuftsin and its analogs

1982 ◽  
Vol 93 (4) ◽  
pp. 452-456
Author(s):  
A. V. Val'dman ◽  
N. A. Bondarenko ◽  
V. A. Kamysheva ◽  
M. M. Kozlovskaya ◽  
V. N. Kalikhevich ◽  
...  
Keyword(s):  
Neurochemical Mechanisms ◽  
Psychotropic Action

P.5.106 Psychotropic action of taftsin derivateSelank

2005 ◽  
Vol 15 ◽  
pp. S261
Author(s):  
M.M. Kozlovskaya ◽  
I.I. Kozlovsky ◽  
M.V. Levina ◽  
I.V. Ribina ◽  
M.A. Yarkova
Keyword(s):  
Psychotropic Action

FEATURES OF BEHAVIORAL STUDY OF LABORATORY ANIMALS DURING EXAMINATION OF SPECIFIC ACTIVITY

2020 ◽  
pp. 5-13
Author(s):  
Kiseleva N.M. ◽  
Borozdenko D.A. ◽  
Shmigol T.A. ◽  
Negrebetsky V.V.
Keyword(s):  
Cognitive Functions ◽  
Specific Activity ◽  
Accurate Determination ◽  
Data Interpretation ◽  
Neurotropic Activity ◽  
Neurological Deficits ◽  
Laboratory Animals ◽  
Psychotropic Action ◽  
The Individual ◽  
Rats And Mice

The study of behavior and cognitive functions is rather difficult to interpret, is time-consuming and has a number of peculiarities both in planning the study and in conducting the tests themselves. For this kind of experiments, Various biomodels are used for such experiments, but this paper we will focus on experiments on the animals most often used in laboratory practice - small laboratory rodents (rats and mice). Most often, there is a need to carry out psychopharmacological studies in order to examine the specific activity of drugs belonging to the group of psychotropic drugs, however, medicine from other pharmacological groups can also have neurotropic activity and expressly influence the behavior and cognitive functions of both animals and humans. The paper highlights the main stages of planning and conducting a study of behavior and cognitive functions, starting with the analysis of power and calculating the sample size, the formation of experimental groups and ending with the features of data interpretation. It also presents the most commonly used psychopharmacological tests, as well as methods for confirming neurological deficits. Thus, it is possible to highlight a number of points enabling the most accurate determination the spectrum of psychotropic action of the studied drugs: The number of animals in groups should be sufficient for statistical analysis and usually ranges from 12 to 14 per group. When forming groups, it is necessary to type the behavior of animals using the Open Field test or its analogue and create groups of animals identical in behavior. When studying the spectrum of psychotropic action, one should not be limited to one or two narrowly targeted tests, but use a whole range of behavioral tests for the most complete picture of the drug's action. When assessing the effect of the drug in some cases, one should not average the results in a group, but use an assessment of the individual change in behavior of each animal.

scholarly journals Epilepsy and marijuana - a review

2005 ◽  
Vol 11 (2) ◽  
pp. 91-93 ◽  
Author(s):  
Fábio Galvão Dantas
Keyword(s):  
Cannabis Sativa ◽  
Single Case ◽  
Case Reports ◽  
Ethical Aspects ◽  
Medicinal Use ◽  
The World ◽  
Psychotropic Action ◽  
Psychotropic Effects

ABSTRACT The medicinal use of components of Cannabis sativa (marijuana) has been studied around the world. Some of these components may have anti-convulsive properties, though the reports are controversial, and sometimes come from single case reports and clinical anecdotes. Because of ethical aspects, as some of the components of cannabis have psychotropic effects, this is a very important issue. New researches have demonstrated that some components of cannabis that don't have psychotropic action may play a role in controlling seizures. This paper reviews the relation between epilepsy and the components of cannabis sativa.

scholarly journals Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1459 ◽  
Author(s):  
Serena Silvestro ◽  
Santa Mammana ◽  
Eugenio Cavalli ◽  
Placido Bramanti ◽  
Emanuela Mazzon
Keyword(s):  
Clinical Trials ◽  
Recent Literature ◽  
Cannabis Sativa ◽  
Antioxidant Properties ◽  
Clinical Applications ◽  
Neuroprotective Activity ◽  
Medical Applications ◽  
Scientific Interest ◽  
Treatment Resistant ◽  
Psychotropic Action

Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from Cannabis sativa. CBD is a terpenophenol and it has received a great scientific interest thanks to its medical applications. This compound showed efficacy as anti-seizure, antipsychotic, neuroprotective, antidepressant and anxiolytic. The neuroprotective activity appears linked to its excellent anti-inflammatory and antioxidant properties. The purpose of this paper is to evaluate the use of CBD, in addition to common anti-epileptic drugs, in the severe treatment-resistant epilepsy through an overview of recent literature and clinical trials aimed to study the effects of the CBD treatment in different forms of epilepsy. The results of scientific studies obtained so far the use of CBD in clinical applications could represent hope for patients who are resistant to all conventional anti-epileptic drugs.

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