Brain morphology and function in rats with varied degree of neurologic recovery after systemic circulatory arrest

1988 ◽  
Vol 105 (1) ◽  
pp. 108-111
Author(s):  
M. Sh. Avrushchenko ◽  
T. L. Marshak ◽  
E. A. Mutuskina
Keyword(s):  
Circulatory Arrest ◽  
Brain Morphology ◽  
Neurologic Recovery ◽  
Varied Degree ◽  
Systemic Circulatory Arrest ◽  
And Function

Dynamics of transcription activity of cerebellar Purkinje cell chromatin after systemic circulatory arrest

1991 ◽  
Vol 111 (3) ◽  
pp. 283-287
Author(s):  
M. Sh. Avrushchenko ◽  
O. V. Bul'chuk ◽  
A. V. Grigor'eva ◽  
T. L. Marshak ◽  
V. N. Yarygin
Keyword(s):  
Purkinje Cell ◽  
Circulatory Arrest ◽  
Cerebellar Purkinje Cell ◽  
Transcription Activity ◽  
Systemic Circulatory Arrest

scholarly journals Long-Term Oral Methylphenidate Treatment in Adolescent and Adult Rats: Differential Effects on Brain Morphology and Function

2013 ◽  
Vol 39 (2) ◽  
pp. 263-273 ◽  
Author(s):  
Kajo van der Marel ◽  
Anne Klomp ◽  
Gideon F Meerhoff ◽  
Pieter Schipper ◽  
Paul J Lucassen ◽  
...  
Keyword(s):  
Brain Morphology ◽  
Adult Rats ◽  
Differential Effects ◽  
And Function

Continuous retrograde hypothermic low flow cerebral perfusion during aortic arch surgery

Perfusion ◽  
1994 ◽  
Vol 9 (2) ◽  
pp. 95-99 ◽  
Author(s):  
Peter A. M. Everts ◽  
Eric Berreklouw ◽  
Monique M. M. Hessels ◽  
Jacques P. A. M. Schönberger
Keyword(s):  
Aortic Arch ◽  
Superior Vena Cava ◽  
Femoral Artery ◽  
Cerebral Perfusion ◽  
Circulatory Arrest ◽  
Superior Vena ◽  
Vena Cava ◽  
Low Flow ◽  
Systemic Circulatory Arrest ◽  
Bypass Line

Continuous retrograde hypothermic low flow cerebral perfusion (CRCP) with deep hypothermic systemic circulatory arrest (DHSCA) during aortic arch surgery was employed in six patients, aged 21-79 years. From August 1991 to November 1992, five of these patients were operated for ascending and arch aortic dissection type I, and one patient was operated for an aneurysm extending from the ascending aorta into the arch. Cardiopulmonary bypass (CPB) technology included a centrifugal pump and low-dose aprotinin. Venous drainage was established via the superior and inferior caval veins and arterial return via the femoral artery. Prior to CPB, a bypass line connecting the arterial line with the superior vena cava cannula was implemented. Prior to DHSCA, the patients were systemically cooled to a mean nasopharyngeal temperature of 15.2°C. After induction of systemic circulatory arrest, the femoral artery cannula was clamped. Thereafter, the implemented bypass line was opened to achieve reverse flow into the superior vena cava to allow venoarterial perfusion. The perfusate was returned to the CPB circuit through drainage from the inferior caval vein and by aspiration of blood from the opened aortic arch. CRCP flow rate ranged from 250 to 450 ml/min (mean 375 ml/min) maintaining an internal jugular vein pressure between 18 and 25 mmHg. The duration of CRCP ranged from 24 to 55 minutes (mean 39 minutes). Postoperatively, one patient died of cardiac failure. The other five patients regained full consciousness without neurological deficits, as defined by the Glasgow coma score, within 48 hours after the operation. Neither did we see other major organ complications. At present four patients are alive nine to 24 months after surgery and they are in New York Heart Association (NYHA) functional classification I-II. Our experience indicates that CRCP is safe and effective, avoiding cerebral circulatory arrest. Furthermore, this technique avoids clamping of cerebral vessels, reduces the chances of embolism of particulate debris and of cerebral air intrusion into opened cerebral vessels.

scholarly journals Impact of Chemotherapy for Childhood Leukemia on Brain Morphology and Function

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e78599 ◽  
Author(s):  
Marina Genschaft ◽  
Thomas Huebner ◽  
Franziska Plessow ◽  
Vasiliki N. Ikonomidou ◽  
Nasreddin Abolmaali ◽  
...  
Keyword(s):  
Childhood Leukemia ◽  
Brain Morphology ◽  
And Function
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