Neurologic recovery after deep hypothermic circulatory arrest in rats: A description of a long‐term survival model without blood priming

2019 ◽  
Vol 43 (6) ◽  
pp. 551-560 ◽  
Author(s):  
Mingyue Liu ◽  
Qingdong Zeng ◽  
Yongnan Li ◽  
Gang Liu ◽  
Bingyang Ji
2018 ◽  
Vol 107 (4) ◽  
pp. 322-328 ◽  
Author(s):  
J. A. Stewart ◽  
V. H. Ilkka ◽  
J. J. Jokinen ◽  
A. P. Vakkuri ◽  
R. T. Suojaranta ◽  
...  

Background and Aims: Hypothermic circulatory arrest carries a high risk of mortality and neurological complications. An important part of assessing surgical treatment is the evaluation of long-term survival and postoperative health-related quality of life. Material and Methods: In this prospective study, 30 patients undergoing hypothermic circulatory arrest during surgery of the thoracic aorta, and 31 comparison patients undergoing elective coronary artery surgery without hypothermic circulatory arrest were evaluated for long-term survival and health-related quality of life, using the RAND 36-Item Health Survey questionnaire. The results were compared to national age- and sex-matched reference populations of the chronically ill and healthy adults. Results: After 4.6–8.0 years, available study (88%) and comparison (59%) patients were interviewed. The life expectancy was similar with 4- and 8-year survival of 90%, and 87% for the study group, and 94%, and 94% for the comparison group, respectively (log rank test, p = 0.62). The RAND-36 scores for study and comparison groups were congruent in all dimensions, describing physical, mental, and social domains. The study patients’ health-related quality of life results were similar to the national reference population with chronic illnesses. Conclusion: After hypothermic circulatory arrest, patients undergoing surgery of the thoracic aorta achieve a similar long-term life expectancy and health-related quality of life as do patients undergoing coronary surgery without hypothermic circulatory arrest, and a health-related quality of life similar to the national reference population with chronic illnesses. These results justify operative treatment in this high-risk patient population.


Sankhya B ◽  
2015 ◽  
Vol 77 (2) ◽  
pp. 207-239 ◽  
Author(s):  
Elizabeth M. Hashimoto ◽  
Edwin M. M. Ortega ◽  
Gauss M. Cordeiro ◽  
Vicente G. Cancho

2012 ◽  
Vol 155 ◽  
pp. S38-S39
Author(s):  
Z. Arslan ◽  
M. Tavlasoglu ◽  
A.E. Denktas ◽  
Y.J. Geng

2017 ◽  
Vol 24 (4) ◽  
pp. 325-337
Author(s):  
Valdemiro Piedade Vigas ◽  
Josmar Mazucheli ◽  
Francisco Louzada

2019 ◽  
Vol 12 (4) ◽  
pp. 561-571
Author(s):  
Diego I. Gallardo ◽  
Heleno Bolfarine ◽  
Antonio C. Pedroso-de-Lima ◽  
Jose S. Romeo

2016 ◽  
Vol 50 (5) ◽  
pp. 892-897 ◽  
Author(s):  
Alexey Dashkevich ◽  
Erik Bagaev ◽  
Christian Hagl ◽  
Maximilian Pichlmaier ◽  
Maximilian Luehr ◽  
...  

2011 ◽  
Vol 114 (3) ◽  
pp. 877-884 ◽  
Author(s):  
Francisco A. Ponce ◽  
Robert F. Spetzler ◽  
Patrick P. Han ◽  
Scott D. Wait ◽  
Brendan D. Killory ◽  
...  

Object The aim of this study was to clarify the surgical indications, risks, and long-term clinical outcomes associated with the use of deep hypothermic circulatory arrest for the surgical treatment of intracranial aneurysms. Methods The authors retrospectively reviewed 105 deep hypothermic circulatory arrest procedures performed in 103 patients (64 females and 39 males, with a mean age of 44.8 years) to treat 104 separate aneurysms. Patients' clinical histories, radiographs, and operative reports were evaluated. There were 97 posterior circulation aneurysms: at the basilar apex in 60 patients, midbasilar artery in 21, vertebrobasilar junction in 11, superior cerebellar artery in 4, and posterior cerebral artery in 1. Seven patients harbored anterior circulation aneurysms. Two additional patients harbored nonaneurysmal lesions. Results Perioperatively, 14 patients (14%) died. Five patients (5%) were lost to late follow-up. At a mean long-term follow-up of 9.7 years, 65 patients (63%) had the same or a better status after surgical intervention, 10 (10%) were worse, and 9 (9%) had died. There were 19 cases (18%) of permanent or severe complications. The combined rate of permanent treatment-related morbidity and mortality was 32%. The mean late follow-up Glasgow Outcome Scale score was 4, and the annual hemorrhage rate after microsurgical clipping during cardiac standstill was 0.5%/year. Ninety-two percent of patients required no further treatment of their aneurysm at the long-term follow-up. Conclusions Cardiac standstill remains an important treatment option for a small subset of complex and giant posterior circulation aneurysms. Compared with the natural history of the disease, the risk associated with this procedure is acceptable.


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