Effect of chalone on hepatocyte proliferation in regenerating liver of mice of different ages

1983 ◽  
Vol 96 (5) ◽  
pp. 1637-1640
Author(s):  
P. A. Karmanov ◽  
N. A. Milyutina ◽  
M. Ya. Nekhlyudova ◽  
R. T. Toguzov ◽  
G. K. Krasyuk ◽  
...  
Keyword(s):  
Hepatocyte Proliferation ◽  
Regenerating Liver ◽  
Different Ages

scholarly journals Transcription factor CREM coordinates the timing of hepatocyte proliferation in the regenerating liver

1998 ◽  
Vol 12 (23) ◽  
pp. 3639-3643 ◽  
Author(s):  
G. Servillo ◽  
M. A. Della Fazia ◽  
P. Sassone-Corsi
Keyword(s):  
Transcription Factor ◽  
Hepatocyte Proliferation ◽  
Regenerating Liver

852 THE NF-κB SUBUNIT C-REL IS INVOLVED IN HEPATOCYTE PROLIFERATION IN CHRONIC INJURED AND REGENERATING LIVER

2009 ◽  
Vol 50 ◽  
pp. S310-S311
Author(s):  
R.G. Gieling ◽  
A.M. Elsharkawy ◽  
D. Cowie ◽  
P. Raychaudhuri ◽  
J.H. Caamaño ◽  
...  
Keyword(s):  
Hepatocyte Proliferation ◽  
Regenerating Liver ◽  
Subunit C

scholarly journals CCAAT/Enhancer Binding Protein-β Is a Transcriptional Regulator of Peroxisome-Proliferator-Activated Receptor-γ Coactivator-1α in the Regenerating Liver

2008 ◽  
Vol 22 (7) ◽  
pp. 1596-1605 ◽  
Author(s):  
Haitao Wang ◽  
T. Harshani Peiris ◽  
A. Mowery ◽  
John Le Lay ◽  
Yan Gao ◽  
...  
Keyword(s):  
Binding Protein ◽  
Hepatocyte Proliferation ◽  
Peroxisome Proliferator ◽  
Regenerating Liver ◽  
Basic Leucine Zipper ◽  
Functional Link ◽  
Peroxisome Proliferator Activated Receptor ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein ◽  
Long Chain

Abstract The transcriptional coactivator peroxisome-proliferator-activated receptor-γ coactivator-1α (PGC-1α) is induced in the liver in response to fasting and coordinates the activation of targets necessary for increasing energy production for gluconeogenesis and ketogenesis. After partial hepatectomy, the liver must restore its mass while maintaining metabolic homeostasis to ensure survival. Here we report that PGC-1α is rapidly and dramatically induced after hepatectomy, with an amplitude of induction that exceeds the fasting response. Maximal activation of PGC-1α after hepatectomy is dependent on the basic leucine zipper transcription factor, CCAAT/enhancer binding protein-β (C/EBPβ), a critical factor in hepatocyte proliferation. We demonstrate in vivo C/EBPβ binding to C/EBP and cAMP response element sites in the PGC-1α promoter and show that the C/EBP site is essential for PGC-1α activation. Expression of the PGC-1α target, carnitine palmitoyl transferase 1a, the rate-limiting enzyme in fatty acid β-oxidation, and of long-chain acyl-coenzyme A dehydrogenase, an enzyme involved in β-oxidation of long chain fatty acids, was significantly reduced in C/EBPβ−/− livers after hepatectomy. These findings identify C/EBPβ as a direct activator of PGC-1α in the regenerating liver. The demonstration of a functional link between C/EBPβ and PGC-1α activation provides a likely mechanism for how upstream signaling pathways in the regenerating liver can enable the adaptation to the changed metabolic status.

scholarly journals Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2530
Author(s):  
Jong Ho Choi ◽  
Sohae Park ◽  
Gi Dae Kim ◽  
Jae Yeon Kim ◽  
Ji Hye Jun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bile Duct ◽  
Liver Regeneration ◽  
Rat Model ◽  
Hepatocyte Proliferation ◽  
Hepatic Regeneration ◽  
Regenerating Liver ◽  
Duct Ligation ◽  
Phosphatase Of Regenerating Liver ◽  
Proliferation Of Hepatocytes

Phosphatase of regenerating liver-1 (PRL-1) controls various cellular processes and liver regeneration. However, the roles of PRL-1 in liver regeneration induced by chorionic-plate-derived mesenchymal stem cells (CP-MSCs) transplantation remain unknown. Here, we found that increased PRL-1 expression by CP-MSC transplantation enhanced liver regeneration in a bile duct ligation (BDL) rat model by promoting the migration and proliferation of hepatocytes. Engrafted CP-MSCs promoted liver function via enhanced hepatocyte proliferation through increased PRL-1 expression in vivo and in vitro. Moreover, higher increased expression of PRL-1 regulated CP-MSC migration into BDL-injured rat liver through enhancement of migration-related signals by increasing Rho family proteins. The dual effects of PRL-1 on proliferation of hepatocytes and migration of CP-MSCs were substantially reduced when PRL-1 was silenced with siRNA-PRL-1 treatment. These findings suggest that PRL-1 may serve as a multifunctional enhancer for therapeutic applications of CP-MSC transplantation.

Hepatocyte proliferation after partial hepatectomy in absence of NF-κB activation

2001 ◽  
Vol 120 (5) ◽  
pp. A359-A359
Author(s):  
S LAURENT ◽  
C SEMPOUX ◽  
Y HORMANS ◽  
L LAMBOTTE
Keyword(s):  
Partial Hepatectomy ◽  
Hepatocyte Proliferation
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