Hypertrophy of liver cells and their nuclei in the regenerating liver of rats of different ages

1968 ◽  
Vol 65 (4) ◽  
pp. 457-460
Author(s):  
Z. A. Ryabinina
Keyword(s):  
Liver Cells ◽  
Regenerating Liver ◽  
Different Ages

The endoplasmic reticulum in regenerating liver cells

1985 ◽  
Vol 240 (1) ◽  
Author(s):  
Lillemor Lewan ◽  
Hadar Emanuelsson
Keyword(s):  
Endoplasmic Reticulum ◽  
Liver Cells ◽  
Regenerating Liver

The effect of liver donors’ age, gender and metabolic state on pancreatic lineage activation

2021 ◽  
Vol 16 (1) ◽  
pp. 19-31
Author(s):  
Ioan V Matei ◽  
Irit Meivar-Levy ◽  
Daniela Lixandru ◽  
Simona Dima ◽  
Ioana R Florea ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Human Liver ◽  
Liver Cells ◽  
Diabetic Patients ◽  
Metabolic State ◽  
Human Liver Cells ◽  
Metabolic States ◽  
Different Ages ◽  
Liver Donors

Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze whether the efficiency of the process is affected by liver donors’ heterogeneity with regard to age, gender and the metabolic state. Materials & methods: TD of liver cells derived from nondiabetic and diabetic donors at different ages was characterized at molecular and cellular levels, in vitro. Results: Neither liver cells proliferation nor the propagated cells TD efficiency directly correlate with the age (3–60 years), gender or the metabolic state of the donors. Conclusion: Human liver cells derived from a wide array of ages and metabolic states can be used for autologous cells therapies for diabetics.

1α, 25-Dihydroxyvitamin D3 enables regenerating liver cells to make functional ribonucleotide reductase subunits and replicate DNA in thyroparathyroidectomized rats

1985 ◽  
Vol 63 (5) ◽  
pp. 319-324 ◽  
Author(s):  
T. Youdale ◽  
J. F. Whitfield ◽  
R. H. Rixon
Keyword(s):  
Body Weight ◽  
Dna Replication ◽  
Ribonucleotide Reductase ◽  
Intraperitoneal Injection ◽  
Liver Cells ◽  
Regenerating Liver ◽  
Dihydroxyvitamin D3 ◽  
Dihydroxyvitamin D ◽  
Do So

Between 16 and 20 h after partial (70%) hepatectomy (HPX) in normal rats, the remaining liver cells accumulate ribonucleotide reductase subunits, assemble these into active holoenzyme, and initiate DNA replication. These late prereplicative activities did not occur in most of the liver cells remaining after HPX in rats which had been thyroparathyroidectomized (TPTX) 72 h previously. However, one intraperitoneal injection of 400 or 600 ng 1α, 25-dihydroxyvitamin D3/100 g body weight at the time of HPX enabled the remaining liver cells in such TPTX rats to make functional ribonucleotide reductase subunits, assemble these subunits into active CDP-reducing holoenzymes, and replicate their DNA, though they started to do so 4 to 16 h later than in normal animals.

Uptake of Protein by Regenerating Liver Cells

Nature ◽  
1964 ◽  
Vol 204 (4964) ◽  
pp. 1210-1211 ◽  
Author(s):  
T. GHOSE ◽  
S. C. TSO
Keyword(s):  
Liver Cells ◽  
Regenerating Liver

The gene encoding rat insulinlike growth factor-binding protein 1 is rapidly and highly induced in regenerating liver

1991 ◽  
Vol 11 (3) ◽  
pp. 1393-1401 ◽  
Author(s):  
K L Mohn ◽  
A E Melby ◽  
D S Tewari ◽  
T M Laz ◽  
R Taub
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Normal Liver ◽  
Liver Cells ◽  
Immediate Early ◽  
Cdna Libraries ◽  
Regenerating Liver ◽  
Liver Growth ◽  
Insulinlike Growth Factor ◽  
Igf I

The liver is an epithelioid organ that can regenerate following partial hepatectomy. Although it is composed mainly of hepatocytes, it has a complex, multicellular architecture, implying that intercellular communications must exist during regeneration. As in other mitogen-stimulated cells, immediate-early growth response genes induced in the absence of prior protein synthesis are likely to play an important regulatory role in the regenerative process. Through differential screening of regenerating liver cDNA libraries, we found that one of the most highly expressed immediate-early genes in liver regeneration encodes the rat homolog of the low-molecular-weight insulinlike growth factor (IGF)-binding protein (IGFBP-1). This protein has been implicated in enhancing the mitogenic effect of IGF on tissues. IGFBP-1 gene induction is transcriptionally mediated and specific to regenerating liver, as the gene is not expressed in mitogen-stimulated fibroblasts. IGFBP-1 expression has been shown to increase under low-insulin conditions such as diabetes, and the complex regulation of expression is indicated by our finding that insulin treatment of H35 rat hepatoma cells, which induces proliferation, also causes a rapid decrease in transcription and expression of the IGFBP-1 gene. Of note, IGFBP-1 mRNA is abundant in fetal rat liver, implying that it participates in normal liver growth and development. Although regenerating liver cells continue to produce IGF-I, we did not detect IGF-I receptor mRNA during the first 24 h after hepatectomy. However, some IGFBPs may act to enhance the activity of IGF-I independently of IGF-I receptors. Thus, IGF-1 and IGFBPs may interact with hepatocytes or nonparenchymal liver cells, through either IGF-I or novel receptors. In this way, IGFBP-I and IGF-I could act in a paracrine and/or autocrine fashion in maintaining normal liver architecture during regeneration.

Intracellular ribonucleic acid composition in regenerating liver cells

1958 ◽  
Vol 27 ◽  
pp. 395-401 ◽  
Author(s):  
Gaston de Lamirande ◽  
Claude Allard ◽  
Antonio Cantero
Keyword(s):  
Acid Composition ◽  
Ribonucleic Acid ◽  
Liver Cells ◽  
Regenerating Liver
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