Combined action of hypoxia and hypercapnia on functional state of the respiratory center

1975 ◽  
Vol 79 (4) ◽  
pp. 389-393 ◽  
Author(s):  
A. M. Kulik ◽  
L. N. Kondrat'eva
Keyword(s):  
Functional State ◽  
Respiratory Center ◽  
Combined Action

scholarly journals Metabolic and functional state of the liver at the combined effect of lead and fluorine on the background of bioprotectors application

2019 ◽  
pp. 28-35
Author(s):  
Yu.V. Fedorenko
Keyword(s):  
Antioxidant Activity ◽  
Alkaline Phosphatase ◽  
Functional State ◽  
Liver Tissue ◽  
Antioxidant Defense ◽  
Phase Changes ◽  
Combined Effect ◽  
Diene Conjugates ◽  
White Rats ◽  
Combined Action

Introduction. The potential danger of combined effect of lead and fluorine to human health motivates the search and experimental substantiation of physiologically acceptable ways of bioprophylaxis directed to preventing or reducing the negative effect on the organism. Objective: the study of the dynamics of the metabolic and functional state of the liver under conditions of combined effect of lead and fluorine without application of bioprotectors and on the background of bioprotectors application. Material and Methods. 4 series of researches were carried out on white rats, each according to the orthogonal planning scheme 22. Lead and fluorine were administered by intragastric within 30 days: in the first series — without bioprotectors application, in the second series — on the background of pectin application, in the third series — pectin and calcium application, in the fourth series — the complex of pectin, calcium and triovit application. The level of diene conjugates, the active products of thiobarbituric acid, the activities of superoxide dis-mutase and catalase, the index of general antioxidant activity in the liver tissue, the activities of alanine aminotransferases, aspartate aminotransferases and alkaline phosphatase in blood serum, concentration of urea were determined at the 15th and 30th day of the experiments, the integral coefficient of antioxidant defense and the type of combined action were calculated. Results. The combined effect of lead and fluorine leads to an imbalance between the indicators of lipoperox-idation and antioxidant activity of the liver tissue, the increased activities of alanine aminotransferases and aspartate aminotransferases, the phase changes in alkaline phosphatase activity, and urea concentration in serum. The application of pectin did not affect the indicators. Pectin and calcium have improved the mechanisms of antioxidant system and the activity of enzymes. The complex of pectin, calcium and triovit normalizes metabolic processes in the liver tissue and improves its functional state. The type of the combined action depends on the registered effect, the duration of the stress factor and the applied bioprotektor. Conclusion. The optimal prophylactic effect under the combined action of lead and fluorine is achieved with the help of a complex of pectin, calcium and triovit. Key Words: lead, fluorine, combined effect, pectin, calcium, triovit, indicators of lipid peroxidation, antioxidant defense, enzyme activity.

The Effect of Stress and Warfarin on the Adrenal Gland in Relation to Spontaneous Hemorrhage, as Judged by Measurement of Adrenal Ascorbic Acid and Serum Corticosterone

1971 ◽  
Vol 26 (02) ◽  
pp. 275-288 ◽  
Author(s):  
S Chattopadhyay ◽  
D. D Johnson ◽  
G. J Millar ◽  
L. B Jaques
Keyword(s):  
Ascorbic Acid ◽  
Acid Concentration ◽  
Ascorbic Acid Concentration ◽  
Corticosterone Concentration ◽  
Serum Corticosterone ◽  
Spontaneous Hemorrhage ◽  
Combined Action ◽  
Series Of Experiments ◽  
Pituitary Adrenal Axis

SummaryRats were subjected to the following procedures: No treatment, Stressor (10% NaCl i.p.), Warfarin for 7 days, Stressor followed by Warfarin; and groups were sacrificed at intervals for assessment of spontaneous hemorrhage and of adrenal ascorbic acid concentration. There was no hemorrhage in the no treatment and stressor groups; some hemorrhage in the warfarin group; profound hemorrhage with Warfarin + Stressor. The adrenal ascorbic acid concentration was found to be lower, 8 h and again 5 days after stress, and remained lower in the warfarin + stress animals. Warfarin had no effect on adrenal ascorbic acid level.In another series of experiments in which the stress consisted of an electric current to the cage floor for 6 sec over 15 min, rats were sacrificed daily for determination of serum corticosterone concentration and occurrence of spontaneous hemorrhage. There was a statistically significant increase of serum corticosterone concentration with stress, warfarin and combined warfarin and stress treatments (P< 0.001 for all three variables). There was a significant correlation (r = 0.96 and 0.89, P< 0.01) for serum corticosterone concentration with hemorrhage score and incidence of hemorrhage in stressed rats receiving warfarin, but not in those receiving only warfarin. The results indicate an activation, rather than an exhaustion, of the pituitary-adrenal axis during the combined action of anticoagulant and stress, which results in the development of spontaneous hemorrhage.

Assessment of the respiratory center output in children with neuromuscular diseases

2006 ◽  
Vol 37 (06) ◽  
Author(s):  
A Hahn ◽  
I Kafadar ◽  
V Busch ◽  
BA Neubauer
Keyword(s):  
Neuromuscular Diseases ◽  
Respiratory Center

Dynamical Peculiarities of Concatenational Changes in Functional Cardiovascular Parameters

2018 ◽  
Vol 3 (82) ◽  
Author(s):  
Eurelija Venskaitytė ◽  
Jonas Poderys ◽  
Tadas Česnaitis
Keyword(s):  
Time Series ◽  
Time Series Analysis ◽  
Functional State ◽  
The Body ◽  
Functional Changes ◽  
High Intensity Training ◽  
Series Analysis ◽  
Greco Roman ◽  
St Segment ◽  
Standard Lead

Research  background  and  hypothesis.  Traditional  time  series  analysis  techniques,  which  are  also  used  for the analysis of cardiovascular signals, do not reveal the relationship between the  changes in the indices recorded associated with the multiscale and chaotic structure of the tested object, which allows establishing short-and long-term structural and functional changes.Research aim was to reveal the dynamical peculiarities of interactions of cardiovascular system indices while evaluating the functional state of track-and-field athletes and Greco-Roman wrestlers.Research methods. Twenty two subjects participated in the study, their average age of 23.5 ± 1.7 years. During the study standard 12 lead electrocardiograms (ECG) were recorded. The following ECG parameters were used in the study: duration of RR interval taken from the II standard lead, duration of QRS complex, duration of JT interval and amplitude of ST segment taken from the V standard lead.Research  results.  Significant  differences  were  found  between  inter-parametric  connections  of  ST  segment amplitude and JT interval duration at the pre and post-training testing. Observed changes at different hierarchical levels of the body systems revealed inadequate cardiac metabolic processes, leading to changes in the metabolic rate of the myocardium and reflected in the dynamics of all investigated interactions.Discussion and conclusions. It has been found that peculiarities of the interactions of ECG indices interactions show the exposure of the  functional changes in the body at the onset of the workload. The alterations of the functional state of the body and the signs of fatigue, after athletes performed two high intensity training sessions per day, can be assessed using the approach of the evaluation of interactions between functional variables. Therefore the evaluation of the interactions of physiological signals by using time series analysis methods is suitable for the observation of these processes and the functional state of the body.Keywords: electrocardiogram, time series, functional state.

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