Pathoanatomical changes in the central nervous system and in the internal organs of white rats when varying doses of barbamyl are used

1956 ◽  
Vol 42 (1) ◽  
pp. 629-634
Author(s):  
A. M. Prokhorova
1957 ◽  
Vol 35 (6) ◽  
pp. 751-768 ◽  
Author(s):  
Bruce M. McCraw

The topographic anatomy of Lymnaea humilis is described, giving the relative positions of the various internal organs. A description of the anatomy of the cephalic hemocoele is also given. Like Lymnaea stagnalis the central nervous system of L. humilis consists of the paired cerebral, buccal, pedal, pleural, and parietal ganglia and the unpaired abdominal ganglion. The nerves arising from the central nervous system are described and particular attention was devoted to the nerves arising from the pedal ganglia and innervating the foot; fourteen new nerves are named or described. The reproductive system of L. humilis is divided into: (a) the ovotestis and its duct, (b) the female system, and (c) the male system. In reproductively active snails, the female system is the largest of the three portions, and consists of the uterus, oothecal gland, vagina, and seminal receptacle. An accessory structure, the albumen gland, is very large in L. humilis. The male system consists of the upper and lower prostate, vas deferens, and male copulatory organ. The connections between the hermaphrodite duct and the male and female systems show considerable structural consolidation compared to these connections in L. stagnalis. The muciparous gland is not a distinct entity in L. humilis.


1936 ◽  
Vol 63 (2) ◽  
pp. 227-240 ◽  
Author(s):  
G. J. Buddingh

1. Chick embryos infected by the chorio-allantoic route with a bacteria-free strain of vaccinia virus develop a general dissemination of the virus throughout the entire organism with the exception of the central nervous system. 2. Quantitative estimation of the distribution of the virus in the various organs of the infected chick by cutaneous inoculation on the rabbit skin offers no evidence for a heightened affinity of the virus for special tissues. 3. Histological study of the lesions in the various organs demonstrates the focal character of the lesions which apparently originate as perivascular infiltrations around the smaller blood vessels. No lesions could be demonstrated in the central nervous system proper. 4. In the earlier stages of the disease Guarnieri bodies are clearly demonstrable in the cells of the epidermis and the squamous epithelium of the buccal mucosa. Inclusion bodies closely resembling Guarnieri bodies are demonstrated in all the lesions occurring in the various other organs. 5. It was not possible to demonstrate conclusively the presence of Paschen bodies in the lesions of the internal organs by the Morosow method usually used for the demonstration of these bodies in the membranal lesion.


2021 ◽  
Vol XXX (3-4) ◽  
pp. 52-53
Author(s):  
Z. A. Zalyalova ◽  
F. Y. Yusupov ◽  
L. Y. Mukhametshina

Neurofibromatosis is a hereditary disease characterized by the presence of many tumors located in the skin, along the peripheral nerves, in the central nervous system, skin pigmentation with bone anomalies, and damage to internal organs.


2020 ◽  
Vol 97 (3) ◽  
pp. 137-142
Author(s):  
I.N. Balashova ◽  
V.V. Goldobin

Wilson-Konovalov disease is a serious progressive hereditary pathology, which is characterized by a violation of copper metabolism and lead to severe changes in the central nervous system and internal organs. In Wilson-Konovalov disease a wide symptoms spectrum of various severity is observed: neurological, behavioral, and psychiatric ones. In the cases of swallowing disorders, voice and speech problems a help of a clinical speech therapist is necessary, who may prolong the patient’s independent nutrition through the mouth and could restore a sonorous voice by the means of speech-therapeutic techniques.


Author(s):  
Gladys Harrison

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.


Author(s):  
John L.Beggs ◽  
John D. Waggener ◽  
Wanda Miller ◽  
Jane Watkins

Studies using mesenteric and ear chamber preparations have shown that interendothelial junctions provide the route for neutrophil emigration during inflammation. The term emigration refers to the passage of white blood cells across the endothelium from the vascular lumen. Although the precise pathway of transendo- thelial emigration in the central nervous system (CNS) has not been resolved, the presence of different physiological and morphological (tight junctions) properties of CNS endothelium may dictate alternate emigration pathways.To study neutrophil emigration in the CNS, we induced meningitis in guinea pigs by intracisternal injection of E. coli bacteria.In this model, leptomeningeal inflammation is well developed by 3 hr. After 3 1/2 hr, animals were sacrificed by arterial perfusion with 3% phosphate buffered glutaraldehyde. Tissues from brain and spinal cord were post-fixed in 1% osmium tetroxide, dehydrated in alcohols and propylene oxide, and embedded in Epon. Thin serial sections were cut with diamond knives and examined in a Philips 300 electron microscope.


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