Effect of follicle size on diurnal changes in mitotic activity in thyroid cells

1971 ◽  
Vol 71 (4) ◽  
pp. 442-444
Author(s):  
Yu. A. Romanov
Keyword(s):  
Mitotic Activity ◽  
Diurnal Changes ◽  
Thyroid Cells ◽  
Follicle Size

Diurnal changes in mitotic activity and DNA synthesis in normal and tumor tissues of rats

1973 ◽  
Vol 76 (6) ◽  
pp. 1439-1441
Author(s):  
L. V. Sokolova ◽  
A. G. Mustafin ◽  
V. N. Dobrokhotov ◽  
S. I. Baluev
Keyword(s):  
Dna Synthesis ◽  
Mitotic Activity ◽  
Diurnal Changes ◽  
Tumor Tissues

Expression of the c-myc proto-oncogene in growth stimulated porcine thyroid follicle cells

1987 ◽  
Vol 116 (1_Suppl) ◽  
pp. S238-S241
Author(s):  
N.-E. Heldin ◽  
F. A. Karlsson ◽  
B. Westermark
Keyword(s):  
Cell Division ◽  
Mitotic Activity ◽  
Functional Activity ◽  
Follicle Cells ◽  
Early Event ◽  
Camp Production ◽  
Thyroid Follicle ◽  
Thyroid Cells ◽  
Rna Levels

Abstract. In the present investigation the expression of c-myc in porcine thyroid follicle cells following the incubation with TSH or EGF was studied. EGF did not only have a mitotic effect on thyroid follicles but also increased c-myc mRNA. The increase in c-myc RNA is an early event in EGF stimulated thyroid cells. TSH had no effect on c-myc RNA levels of porcine thyroid cells. EGF-binding and sensitization to the mitotic activity of EGF, however, is increased by TSH. While TSH stimulates cAMP production and functional activity but not growth or c-myc expression of porcine thyroid cells, EGF produces cell division accompanied with c-myc expression.

The Relation Between the Epidermal Mitotic Activity and the Blood-Sugar Level in the Adult Male Mouse, Mus Musculus L

1949 ◽  
Vol 26 (1) ◽  
pp. 83-99
Author(s):  
W. S. BULLOUGH
Keyword(s):  
Mitotic Activity ◽  
Blood Sugar ◽  
Adult Male ◽  
Male Mouse ◽  
Blood Sugar Level ◽  
Normal Animal ◽  
Critical Factor ◽  
Diurnal Changes ◽  
Adult Male Mouse ◽  
Mitosis Rate

1. An investigation has been made of the relation between the concentration of the blood sugar and the mitotic activity of the ear epidermis of the adult male mouse. It has been shown that, within limits, an increase in the blood-sugar level, induced by subcutaneous injections of starch, results in an increased mitosis rate. Conversely, a decrease in the blood-sugar level, induced by insulin, causes a decreased mitosis rate. A deep mitosis depression is also caused by injections of phloridzin. 2. Since it is known that phloridzin interferes with the phosphorylation of sugar, and since it is also shown that injections of phosphate augment the effect produced by starch alone, the tentative suggestion is put forward that sugar may act by satisfying the energy requirements of mitosis. 3. However, in the normal animal the diurnal changes in the blood-sugar level are the inverse of the diurnal changes in mitotic activity, the concentration of the blood sugar being relatively low during sleep when the mitosis rate is relatively high. It is therefore evident that, within normal limits, the level of the blood sugar as such is not an important factor in the control of the diurnal mitosis cycles. 4. It is considered probable that the critical factor in the control of these cycles is the concentration of sugar, or glycogen, within the tissues themselves. Thus during sleep, sugar is probably deposited in the tissues, as it is known to be in the liver, so accounting simultaneously for the fall in the level of the blood sugar and the rise in the mitosis rate.

An adrenocortical oncocytoma with unusual mitochondrial inclusions and cytoplasmic crystals

1994 ◽  
Vol 52 ◽  
pp. 250-251
Author(s):  
W.T. Gunning ◽  
G.D. Haselhuhn ◽  
E.R. Phillips ◽  
S.H. Selman
Keyword(s):  
Adrenal Gland ◽  
Salivary Glands ◽  
Mitotic Activity ◽  
Diagnostic Criteria ◽  
Vascular Invasion ◽  
Benign Neoplasm ◽  
Benign Tumors ◽  
Nuclear Morphology ◽  
Case Presentation ◽  
Microscopic Evidence

Within the last few years, adrenal cortical tumors with features concordant with the diagnostic criteria attributed to oncocytomas have been reported. To date, only nine reported cases exist in the literature. This report is the tenth case presentation of a presumptively benign neoplasm of the adrenal gland with a rare differentiation. Oncocytomas are well recognized benign tumors of the thyroid, parathyroid, and salivary glands and of the kidney. Other organs also give rise to these types of tumors, however with less frequency than the former sites. The characteristics generally used to classify a tumor as an oncocytoma include the following criteria: the tumor is 1) usually a solitary circumscribed mass with no gross nor microscopic evidence of metastasis (no tissue nor vascular invasion), 2) fairly bland in terms of mitotic activity and nuclear morphology, and 3) composed of large eosinophillic cells in which the cytoplasm is packed full of mitochondria (Figure 1).

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