Distribution of activity of enzymes synthesizing and hydrolyzing cholesterol esters in the human aorta

1978 ◽  
Vol 86 (6) ◽  
pp. 1602-1604
Author(s):  
P. P. Garyaev ◽  
G. A. Zakharkina ◽  
A. M. Vikhert
Keyword(s):  
Human Aorta ◽  
Cholesterol Esters ◽  
Activity Of Enzymes

Effect of dibutyryl-cAMP on the content of cholesterol esters in cells of the atherosclerotic human aorta

1983 ◽  
Vol 95 (5) ◽  
pp. 678-680
Author(s):  
V. V. Tertov ◽  
A. N. Orekhov ◽  
V. S. Repin ◽  
V. N. Smirnov
Keyword(s):  
Human Aorta ◽  
Cholesterol Esters ◽  
Dibutyryl Camp ◽  
In Cells

Position of double bonds in the fatty acids of cholesterol esters from human aorta

1970 ◽  
Vol 12 (1) ◽  
pp. 63-74 ◽  
Author(s):  
J.C. Geer ◽  
R.V. Panganamala ◽  
D.G. Cornwell
Keyword(s):  
Fatty Acids ◽  
Human Aorta ◽  
Cholesterol Esters ◽  
Double Bonds

Structural aspects of osmoregulation in porphyra

1978 ◽  
Vol 36 (2) ◽  
pp. 412-413
Author(s):  
C. Wiencke ◽  
A. Lauchli
Keyword(s):  
Culture Medium ◽  
Point Of View ◽  
Chemical Fixation ◽  
Cellular Organization ◽  
Osmotic Adaptation ◽  
Osmotic Balance ◽  
Activity Of Enzymes ◽  
Osmotic Agents ◽  
Vacuolar System ◽  
Structural Aspects

Osmoregulatory mechanisms in algae were investigated mainly from a physiological point of view (KAUSS 1977, HELLEBUST 1976). In Porphyra two osmotic agents, i. e. floridoside/isofloridoside (KAUSS 1968) and certain ions, such as K+ and Na+(EPPLEY et al. 1960) are considered for osmotic balance. Accumulations of ions (particularly Na+) in the cytoplasm during osmotic adaptation is improbable, because the activity of enzymes is generally inhibited by high ionic concentrations (FLOWERS et al. 1977).The cellular organization of Porphyra was studied with special emphasis on the development of the vacuolar system under different hyperosmotic conditions. Porphyra was cultivated at various strengths of the culture medium ASP 12 (PROVASOLI 1961) ranging from normal to 6 times concentrated (6x) culture medium. Por electron microscopy freeze fracturing was used (specimens fixed in 2% glutaraldehyde and incubated in 30% glycerol, preparation in a BALZERS BA 360 M apparatus), because chemical fixation gave poor results.

Intralysosomal Accumulation of Colloidal Gold-Low Density Lipoprotein Conjugates in Chloroquine-Treated Fibroblasts

1985 ◽  
Vol 43 ◽  
pp. 546-547 ◽  
Author(s):  
Dean A. Handley ◽  
Cynthia M. Arbeeny ◽  
Larry D. Witte
Keyword(s):  
Colloidal Gold ◽  
Cultured Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coated Vesicle ◽  
Low Density ◽  
Cholesterol Esters ◽  
Cultured Fibroblasts ◽  
Surface Receptors ◽  
Ldl Particles

Low density lipoproteins (LDL) are the major cholesterol carrying particles in the blood. Using cultured cells, it has been shown that LDL particles interact with specific surface receptors and are internalized via a coated pit-coated vesicle pathway for lysosomal catabolism. This (Pathway has been visualized using LDL labeled to ferritin or colloidal gold. It is now recognized that certain lysomotropic agents, such as chloroquine, inhibit lysosomal enzymes that degrade protein and cholesterol esters. By interrupting cholesterol ester hydrolysis, chloroquine treatment results in lysosomal accumulation of cholesterol esters from internalized LDL. Using LDL conjugated to colloidal gold, we have examined the ultrastructural effects of chloroquine on lipoprotein uptake by normal cultured fibroblasts.

The risk to develop NIDDM is related to the fatty acid composition of the serum cholesterol esters

Diabetes ◽  
1994 ◽  
Vol 43 (11) ◽  
pp. 1353-1357 ◽  
Author(s):  
B. Vessby ◽  
A. Aro ◽  
E. Skarfors ◽  
L. Berglund ◽  
I. Salminen ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Serum Cholesterol ◽  
Cholesterol Esters
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