In vivo study of the oxygen tension in the brain tissues during prolonged acceleration

1964 ◽  
Vol 55 (1) ◽  
pp. 37-40
Author(s):  
E. A. Kovalenko ◽  
V. L. Popkov ◽  
I. N. Chernyakov
Keyword(s):  
Oxygen Tension ◽  
In Vivo Study ◽  
The Brain ◽  
Brain Tissues

Experimental in-vivo study of laser-tissue interaction on the brain: influence of gaseous environment

1990 ◽  
Author(s):  
Maria C. Chavantes ◽  
Lucia J. Zamorano ◽  
Federico Vinas ◽  
Manuel Dujovny ◽  
Ljubisa Dragovic
Keyword(s):  
In Vivo Study ◽  
Tissue Interaction ◽  
Gaseous Environment ◽  
Laser Tissue Interaction ◽  
The Brain

Paclitaxel-loaded dextran nanoparticles decorated with RVG29 peptide for targeted chemotherapy of glioma: an in vivo study

2020 ◽  
Vol 44 (15) ◽  
pp. 5692-5701
Author(s):  
Hailing Han ◽  
Ying Zhang ◽  
Shunzi Jin ◽  
Ping Chen ◽  
Shi Liu ◽  
...  
Keyword(s):  
In Vivo Study ◽  
Targeted Chemotherapy ◽  
Brain Glioma ◽  
The Brain

The RVG29–dextran–PTX nanoparticles can cross the BBB, reach the brain glioma, and thus improve PTX efficacy.

l-Threodops increases extracellular norepinephrine levels in the brain: An in vivo study

Neurology ◽  
1990 ◽  
Vol 40 (7) ◽  
pp. 1134-1134 ◽  
Author(s):  
T. Brannan ◽  
A. Bhardwaj ◽  
M. D. Yahr
Keyword(s):  
In Vivo Study ◽  
The Brain

Effects of the Coreopsis tinctoria extracts on anti-agingin the aging model mice

2016 ◽  
Author(s):  
Weixin Zhang ◽  
Haiyan Hao ◽  
Ailong Sha
Keyword(s):  
Hydrogen Peroxide ◽  
Aging Effects ◽  
Once Daily ◽  
Aging Model ◽  
Coreopsis Tinctoria ◽  
Kg Medium ◽  
The Brain ◽  
Liver Tissues ◽  
Brain Tissues

The effects of the Coreopsis tinctoria extracts on anti-aging were observed by investigating the cerebral index and viscera indexes, the contents of hydrogen peroxide (H2O2) and malondialdehyde (MDA) in the serums, the activities of glutathione peroxidase (GSH-Px) in the brain tissues and the ones of catalase (CAT) and superoxide dismutase (SOD) in the liver tissues of the aging model mice. The aging model mice were injected subcutaneously with D-galactose in vivo and intragastric administrated with the Coreopsis tinctoria extracts at doses of low (0.5g/kg), medium (1g/ kg) and high (2g/ kg) once daily for 6 weeks. The results showed that all the cerebral index, spleen index, thymus index, liver index and kidney index of the three groups dosed of the Coreopsis tinctoria extracts increased, the activities of GSH-Px in the brain tissues and the ones of CAT and SOD in the liver tissues increased to different degree while the contents of H2O2 and MDA in the serums decreased extremely and significantly (P<0.01) compared with the aging model mice. All of these results suggested that the Coreopsis tinctoria extracts might possess anti-aging effects by improving antioxidant capacity of the mice.

Pressure, oxygen tension and temperature in the periosteal callus during bone healing—An in vivo study in sheep

Bone ◽  
2008 ◽  
Vol 43 (4) ◽  
pp. 734-739 ◽  
Author(s):  
Devakara R. Epari ◽  
Jasmin Lienau ◽  
Hanna Schell ◽  
Florian Witt ◽  
Georg N. Duda
Keyword(s):  
Oxygen Tension ◽  
Bone Healing ◽  
In Vivo Study ◽  
Pressure Oxygen ◽  
Periosteal Callus

scholarly journals Analysis of Long Noncoding RNA and mRNA Expression Profiles in IL-9-Activated Astrocytes and EAE Mice

2018 ◽  
Vol 45 (5) ◽  
pp. 1986-1998 ◽  
Author(s):  
Xiaomei Liu ◽  
Qing Zhang ◽  
Weixiao Wang ◽  
Dongjiao Zuo ◽  
Jing Wang ◽  
...  
Keyword(s):  
Gene Ontology ◽  
Pathway Analysis ◽  
Kegg Pathway ◽  
Expression Profiles ◽  
Astrocyte Activation ◽  
Kegg Pathway Analysis ◽  
The Brain ◽  
Brain Tissues

Background/Aims: Multiple sclerosis (MS) is an autoimmune disease in the central nervous system associated with demyelination and axonal injury. Astrocyte activation is involved in the pathogenesis of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS. This study was designed to find potential lncRNAs in EAE mice and activated astrocytes. Methods: we performed microarray analysis of lncRNAs from the brain tissues of EAE mice and primary mouse astrocytes treated with IL-9(50 ng/ml). 12 lncRNAs were validated through real-time PCR. Gene ontology and KEGG pathway analysis were applied to explore the potential functions of lncRNAs. Results: Differentially expressed 3300 lncRNAs and 3250 mRNAs were in the brain tissues of EAE mice, and 3748 lncRNAs and 3332 mRNAs were in activated astrocytes. Notably, there were 2 co-up-regulated lncRNAs and 3 co-down-regulated lncRNAs both in the brain tissues of EAE mice and in activated astrocytes, including Gm14005, Gm12478, mouselincRNA1117, AK080435, and mouselincRNA0681, which regulate the ER calcium flux kinetics, zinc finger protein and cell apoptosis. Similarly, there were 7 mRNAs co-up-regulated and 2 mRNAs co-down-regulated both in vivo and in vitro. Gene ontology and KEGG pathway analysis showed that the biological functions of differentially expressed mRNAs were associated with metabolism, development and inflammation. The results of realtime PCR validation were consistent with the data from the microarrays. Conclusions: Our data uncovered the expression profiles of lncRNAs and mRNAs in vivo and in vitro, which may help delineate the mechanisms of astrocyte activation during MS/EAE process.

scholarly journals Numerical Simulations of MREIT Conductivity Imaging for Brain Tumor Detection

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Zi Jun Meng ◽  
Saurav Z. K. Sajib ◽  
Munish Chauhan ◽  
Rosalind J. Sadleir ◽  
Hyung Joong Kim ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Human Subjects ◽  
Three Dimensional ◽  
Tumor Detection ◽  
Head Model ◽  
Impedance Tomography ◽  
The Brain ◽  
T System ◽  
Brain Tissues

Magnetic resonance electrical impedance tomography (MREIT) is a new modality capable of imaging the electrical properties of human body using MRI phase information in conjunction with external current injection. Recentin vivoanimal and human MREIT studies have revealed unique conductivity contrasts related to different physiological and pathological conditions of tissues or organs. When performingin vivobrain imaging, small imaging currents must be injected so as not to stimulate peripheral nerves in the skin, while delivery of imaging currents to the brain is relatively small due to the skull’s low conductivity. As a result, injected imaging currents may induce small phase signals and the overall low phase SNR in brain tissues. In this study, we present numerical simulation results of the use of head MREIT for brain tumor detection. We used a realistic three-dimensional head model to compute signal levels produced as a consequence of a predicted doubling of conductivity occurring within simulated tumorous brain tissues. We determined the feasibility of measuring these changes in a time acceptable to human subjects by adding realistic noise levels measured from a candidate 3 T system. We also reconstructed conductivity contrast images, showing that such conductivity differences can be both detected and imaged.

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