Effect of regeneration of hematopoietic organs on the number and type of splenic colonies

1978 ◽  
Vol 85 (2) ◽  
pp. 223-225
Author(s):  
G. K. Sukhova ◽  
T. R. Podrabinek ◽  
G. V. Kharlova
Keyword(s):  
Hematopoietic Organs ◽  
Splenic Colonies

scholarly journals Effects of irradiation of recipient mice on the behavior and leukemogenic potential of factor-dependent hematopoietic cell lines

Blood ◽  
1990 ◽  
Vol 75 (1) ◽  
pp. 190-197 ◽  
Author(s):  
U Duhrsen ◽  
D Metcalf
Keyword(s):  
Latent Period ◽  
Leukemic Cells ◽  
Hematopoietic Organs ◽  
Radiation Induced ◽  
Leukemia Development ◽  
Long Term Survivors ◽  
Hematopoietic Cell Lines

Abstract After intravenous (IV) injection with factor-dependent FDC-P1 cells, irradiated DBA/2 and BALB/c mice developed transplantable leukemias owing to neoplastic transformation of the injected cells in vivo. Increasing the radiation dose shortened the preleukemic latent period, and in female mice the frequency of leukemia development was higher and the latent period shorter than in male mice. In the preleukemic period, the injected FDC-P1 cells rapidly increased in number in hematopoietic organs of irradiated animals, reaching peak levels 3 to 5 weeks after injection; factor-independent transformed cells were not detected before day 45. In unirradiated animals, these events were delayed by several weeks, and long-term survivors did not harbor detectable FDC-P1 cells. FDC-P1 cells sampled from preleukemic mice frequently showed atypical colony formation and reduced cloning efficiency in vitro, suggesting the occurrence of a distinct preleukemic change. U16.6 cells produced leukemia only in irradiated recipients, and the leukemic cells usually remained factor dependent. The two contrasting models should be of value in further analyzing the mechanisms underlying radiation- induced leukemias.

scholarly journals Tracing Hematopoietic Precursor Migration to Successive Hematopoietic Organs during Zebrafish Development

Immunity ◽  
2006 ◽  
Vol 25 (6) ◽  
pp. 963-975 ◽  
Author(s):  
Emi Murayama ◽  
Karima Kissa ◽  
Agustin Zapata ◽  
Elodie Mordelet ◽  
Valérie Briolat ◽  
...  
Keyword(s):  
Zebrafish Development ◽  
Hematopoietic Organs ◽  
Hematopoietic Precursor

scholarly journals Effect of Chemical Protection and Bone Marrow Treatment on Radiation Injury in Mice

Blood ◽  
1958 ◽  
Vol 13 (7) ◽  
pp. 665-676 ◽  
Author(s):  
PAUL URSO ◽  
C. C. CONGDON ◽  
D. G. DOHERTY ◽  
RAYMOND SHAPIRA
Keyword(s):  
Bone Marrow ◽  
Body Weight ◽  
Radiation Injury ◽  
Combined Treatment ◽  
X Rays ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Hematopoietic Organs ◽  
X Irradiation ◽  
Bone Marrow Granulocytes

Abstract MEG (prepared from 9.0 mg. of AET) significantly modified the response of the bone marrow, peripheral blood leukocytes, spleen, thymus, body weight, hematocrit, and histology of the hematopoietic organs to lethal (900 r) and sublethal (450 r) x-irradiation in CAF1 mice. MEG reduced the effect of 900 r on the bone marrow, granulocytes of the blood, hematocrit, spleen, thymus, and body weight by a factor of approximately two. Combined treatment (MEG and isologous bone marrow) of mice exposed to 900 r of x-rays demonstrated that MEG is primarily responsible for preventing the early destruction of the bone marrow, but bone marrow injection was primarily responsible for causing a more rapid recovery of the bone marrow. In mice receiving combined treatment, recovery of the leukocytes and spleen was primarily influenced by the bone marrow injection; whereas recovery of the thymus and body weight was primarily influenced by MEG. The hematocrit values were normal after combined treatment.

Mutation in theDrosophila gene encoding ribosomal protein S21 causes tissue overgrowth of the hematopoietic organs

1995 ◽  
Vol 121 (S1) ◽  
pp. A68-A68 ◽  
Author(s):  
Daniela Herrmann ◽  
Istvan Török ◽  
Gabriella Tick ◽  
Istvan Kiss ◽  
Bernand M. Mechler
Keyword(s):  
Ribosomal Protein ◽  
Gene Encoding ◽  
Hematopoietic Organs
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