Role of tonic activity of the respiratory muscles in regulation of human respiration

1968 ◽  
Vol 66 (2) ◽  
pp. 823-825
Author(s):  
E. N. Domontovich ◽  
I. A. Panchenko
Keyword(s):  
Respiratory Muscles ◽  
Tonic Activity ◽  
Human Respiration

Respiratory response to partial paralysis in anesthetized dogs

1984 ◽  
Vol 56 (6) ◽  
pp. 1583-1588 ◽  
Author(s):  
A. Oliven ◽  
E. C. Deal ◽  
S. G. Kelsen ◽  
N. S. Cherniack
Keyword(s):  
Motor Activity ◽  
Respiratory Muscle ◽  
Respiratory Muscles ◽  
Peak Activity ◽  
Inspiratory Time ◽  
Muscle Paralysis ◽  
Anesthetized Dogs ◽  
Spontaneously Breathing ◽  
Partial Paralysis

The ability to maintain alveolar ventilation is compromised by respiratory muscle weakness. To examine the independent role of reflexly mediated neural mechanisms to decreases in the strength of contraction of respiratory muscles, we studied the effects of partial paralysis on the level and pattern of phrenic motor activity in 22 anesthetized spontaneously breathing dogs. Graded weakness induced with succinylcholine decreased tidal volume and prolonged both inspiratory and expiratory time causing hypoventilation and hypercapnia. Phrenic peak activity as well as the rate of rise of the integrated phrenic neurogram increased. However, when studied under isocapnic conditions, increases in the severity of paralysis, as assessed from the ratio of peak diaphragm electromyogram to peak phrenic activity, produced progressive increases in inspiratory time and phrenic peak activity but did not affect its rate of rise. After vagotomy, partial paralysis induced in 11 dogs with succinylcholine also prolonged the inspiratory burst of phrenic activity, indicating that vagal reflexes were not solely responsible for the alterations in respiratory timing. Muscle paresis was also induced with gallamine or dantrolene, causing similar responses of phrenic activity and respiratory timing. Thus, at constant levels of arterial CO2 in anesthetized dogs, respiratory muscle partial paralysis results in a decrease in breathing rate without changing the rate of rise of respiratory motor activity. This is not dependent solely on vagally mediated reflexes and occurs regardless of the pharmacological agent used. These observations in the anesthetized state are qualitatively different from the response to respiratory muscle paralysis or weakness observed in awake subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Contribution to sympathetic vasomotor tone of tonic glutamatergic inputs to neurons in the RVLM

2004 ◽  
Vol 287 (6) ◽  
pp. R1335-R1343 ◽  
Author(s):  
Jouji Horiuchi ◽  
Suzanne Killinger ◽  
Roger A. L. Dampney
Keyword(s):  
Excitatory Amino Acid ◽  
Ventrolateral Medulla ◽  
Tonic Activity ◽  
Vasomotor Tone ◽  
Renal Sympathetic Nerve Activity ◽  
Vehicle Injection ◽  
Sympathetic Vasomotor Tone ◽  
Modest Reduction ◽  
Renal Sympathetic

The role of excitatory amino acid (EAA) receptors in the rostral ventrolateral medulla (RVLM) in maintaining resting sympathetic vasomotor tone remains unclear. It has been proposed that EAA receptors in the RVLM mediate excitatory inputs both to presympathetic neurons and to interneurons in the caudal ventrolateral medulla (CVLM), which then provide a counterbalancing inhibition of RVLM presympathetic neurons. In this study, we tested this hypothesis by determining the effect of blockade of EAA receptors in the RVLM on mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA), after inhibition of CVLM neurons. In anesthetized rats, bilateral injections of muscimol in the CVLM increased MAP, HR, and RSNA. Subsequent bilateral injections of kynurenic acid (Kyn, 2.7 nmol) in the RVLM caused a modest reduction of ∼20 mmHg in the MAP but had no effect, when compared with the effect of vehicle injection alone, on HR or RSNA. By ∼50 min after the injections of Kyn or vehicle in the RVLM, the MAP had stabilized at a level close to its original baseline level, but the HR and RSNA stabilized at levels above baseline. The results indicate that removal of tonic EAA drive to RVLM neurons has little effect on the tonic activity of RVLM presympathetic neurons, even when inputs from the CVLM are blocked. Thus the tonic activity of RVLM presympathetic neurons under these conditions is dependent on excitatory synaptic inputs mediated by non-EAA receptors and/or the autoactivity of these neurons.

Relation between work output of respiratory muscles and end-tidal CO2 tension

1963 ◽  
Vol 18 (3) ◽  
pp. 497-504 ◽  
Author(s):  
J. Milic-Emili ◽  
J. M. Tyler
Keyword(s):  
Carbon Dioxide ◽  
Pulmonary Ventilation ◽  
Respiratory Muscles ◽  
Normal Subjects ◽  
Work Output ◽  
Inspiratory Muscles ◽  
Expiratory Muscles ◽  
End Tidal ◽  
End Tidal Co2

End-tidal CO2 tension, pulmonary ventilation, and work output of respiratory muscles were determined in six normal subjects breathing various mixtures of carbon dioxide in air, with three graded resistances added to both inspiration and expiration. In two individuals, the resistances were also added separately to inspiration or expiration. A linear relationship was found between work output of inspiratory muscles and end-tidal CO2 tension; this relationship was uninfluenced by added resistance. No consistent relationship was observed between either ventilation or work output of expiratory muscles and end-tidal CO2 tension. These results suggest that carbon dioxide controls directly the activity of inspiratory muscles alone and that the activity of expiratory muscles is only coincidentally involved. The possible role of intrinsic properties of respiratory muscles and of nervous mediation in the control of breathing is discussed. Submitted on October 22, 1962

The Role of Respiratory Muscles in the Hyperinflation of Bronchial Asthma1–3

1980 ◽  
Vol 121 (3) ◽  
pp. 441-447 ◽  
Author(s):  
J. Martin ◽  
E. Powell ◽  
S. Shore ◽  
J. Emrich ◽  
L. A. Engel
Keyword(s):  
Respiratory Muscles

scholarly journals Maintaining motor units into old age: running the final common pathway

2017 ◽  
Vol 27 (1) ◽  
Author(s):  
Geoffrey A. Power ◽  
Brian H. Dalton ◽  
Kevin J. Gilmore ◽  
Matti D. Allen ◽  
Timothy J. Doherty ◽  
...  
Keyword(s):  
Physical Activity ◽  
Old Age ◽  
Fiber Type ◽  
Motor Units ◽  
Tonic Activity ◽  
Common Pathway ◽  
Slow Fiber ◽  
Masters Athletes ◽  
And Function

This article is a commentary on the recently published manuscript "Use it or lose it: tonic activity of slow motoneurons promotes their survival and preferentially increases slow fiber-type groupings in muscles of old lifelong recreational sportsmen". Mosole S, Carraro U, Kern H, Loefler S, Zampieri S. Use it or lose it: tonic activity of slow motoneurons promotes their survival and preferentially increases slow fiber-type groupings in muscles of old lifelong recreational sportsmen. Eur J Transl Myol 2016;26:5972. doi: 10.4081/ejtm.2016.5972. We offer some unique perspectives on masters athletes and the role of physical activity in maintaining the number and function of motor units into old age.

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