scholarly journals Maintaining motor units into old age: running the final common pathway

Author(s):  
Geoffrey A. Power ◽  
Brian H. Dalton ◽  
Kevin J. Gilmore ◽  
Matti D. Allen ◽  
Timothy J. Doherty ◽  
...  

This article is a commentary on the recently published manuscript "Use it or lose it: tonic activity of slow motoneurons promotes their survival and preferentially increases slow fiber-type groupings in muscles of old lifelong recreational sportsmen". Mosole S, Carraro U, Kern H, Loefler S, Zampieri S. Use it or lose it: tonic activity of slow motoneurons promotes their survival and preferentially increases slow fiber-type groupings in muscles of old lifelong recreational sportsmen. Eur J Transl Myol 2016;26:5972. doi: 10.4081/ejtm.2016.5972. We offer some unique perspectives on masters athletes and the role of physical activity in maintaining the number and function of motor units into old age.

2006 ◽  
Vol 3 (2) ◽  
pp. 89-97 ◽  
Author(s):  
Eva Elkjaer ◽  
Tine Poulsen ◽  
Kirsten Avlund

2021 ◽  
Vol 2 (1) ◽  
pp. 17
Author(s):  
Arif Rahman AS

Photography takes a big role in the delivery of information, documentation, promotion of product to works of art. Through Saujana Sumpu’s photobook, Yoppy Pieter tries to convey information about a village as a result of most of her brides choosing to settle in urban areas. In the Saujana Sumpu’s photobook, Yoppy presents the Rumah Gadang object and its activities in several photos. This study examines the meaning of photos in Yoppy Pieter’s Saujana Sumpu photobook in which there are the Rumah Gadang object and its activities. This study uses a qualitative method. The theory used in this research is the Semiotics of Roland Barthes. The result of the analysis obtained, there are three main points that Yoppy wants to tell, namely the Rumah Gadang with its history and function, the role of women in the Rumah Gadang, and the silence that occurs in the Rumah Gadang due to its lagging. All photos of Yoppy are presented in black and white colors that give the impression of old age, memories, and what has passed.ABSTRAK Fotografi berperan besar dalam penyampaian informasi, dokumentasi, promosi produk hingga karya seni. Melalui photobook Saujana Sumpu, Yoppy Pieter mencoba menyampaikan informasi tentang sebuah desa akibat sebagian besar pengantinnya memilih untuk menetap di perkotaan. Dalam photobook Saujana Sumpu, Yoppy menampilkan objek Rumah Gadang dan aktivitasnya dalam beberapa foto. Penelitian ini mengkaji tentang makna foto dalam photobook Saujana Sumpu karya Yoppy Pieter yang di dalamnya terdapat objek Rumah Gadang dan aktivitasnya. Penelitian ini menggunakan metode kualitatif. Teori yang digunakan dalam penelitian ini adalah Semiotika Roland Barthes. Hasil analisis yang diperoleh, ada tiga poin utama yang ingin disampaikan Yoppy, yaitu Rumah Gadang dengan sejarah dan fungsinya, peran perempuan dalam Rumah Gadang, dan keheningan yang terjadi di Rumah Gadang karena ketertinggalannya. . Semua foto Yoppy dihadirkan dalam warna hitam putih yang memberikan kesan tua, kenangan, dan apa yang telah berlalu. Kata Kunci: Rumah Gadang; Perempuan; Kesunyian; Fotografi; Yoppy Pieter.


Author(s):  
Simone Mosole ◽  
Ugo Carraro ◽  
Helmut Kern ◽  
Stefan Loefler ◽  
Sandra Zampieri

Histochemistry, immuno-histochemistry, gel electrophoresis of single muscle fibers and electromyography of aging muscles and nerves suggest that: i) denervation contributes to muscle atrophy, ii) impaired mobility accelerates the process, and iii) lifelong running protects against loss of motor units. Recent corroborating results on the muscle effects of Functional Electrical Stimulation (FES) of aged muscles will be also mentioned, but we will in particular discuss how and why a lifelong increased physical activity sustains reinnervation of muscle fibers. By analyzing distribution and density of muscle fibers co-expressing fast and slow Myosin Heavy Chains (MHC) we are able to distinguish the transforming muscle fibers due to activity related plasticity, to those that adapt muscle fiber properties to denervation and reinnervation. In muscle biopsies from septuagenarians with a history of lifelong high-level recreational activity we recently observed in comparison to sedentary seniors: 1. decreased proportion of small-size angular myofibers (denervated muscle fibers); 2. considerable increase of fiber-type groupings of the slow type (reinnervated muscle fibers); 3. sparse presence of muscle fibers co-expressing fast and slow MHC. Immuno-histochemical characteristics fluctuate from those with scarce fiber-type modulation and groupings to almost complete transformed muscles, going through a process in which isolated fibers co-expressing fast and slow MHC fill the gaps among fiber groupings. Data suggest that lifelong high-level exercise allows the body to adapt to the consequences of the age-related denervation and that it preserves muscle structure and function by saving otherwise lost muscle fibers through recruitment to different slow motor units. This is an opposite behavior of that described in long term denervated or resting muscles. These effects of lifelong high level activity seems to act primarily on motor neurons, in particular on those always more active, i.e., on the slow motoneurons. The preferential reinnervation that follows along decades of increased activity maintains neuron and myofibers. All together the results open interesting perspectives for applications of FES and electroceuticals for rejuvenation of aged muscles to delay functional decline and loss of independence that are unavoidable burdens of advanced aging. Trial Registration: ClinicalTrials.gov: NCT01679977.


2005 ◽  
Vol 29 (3) ◽  
pp. 101-103 ◽  
Author(s):  
David Lawley ◽  
John Bestley ◽  
Andy Talbot ◽  
Gary Hostick

There is increased recognition that the role and function of a consultant psychiatrist is ill-defined and associated with excessive workloads, low job satisfaction, high levels of stress and high rates of premature retirement (Kennedy & Griffiths, 2001). This has led to an examination and debate about how consultants in general psychiatry could adapt models of working to address these difficulties, and also face the agenda of change facing the NHS as a whole and the mental health services in particular (Kennedy & Griffiths, 2001; De Silva & Sutcliffe, 2003). These challenges are not, of course, unique to general psychiatry, but as yet, there has been little debate about how consultants in other specialities, including old age psychiatry, could begin to try and address these difficulties. This article aims to stimulate debate, by describing an adapted model of working adopted by two consultants in old age psychiatry within the Hull and East Riding Community Health NHS Trust.


2021 ◽  
Vol 10 (2) ◽  
pp. 59-64
Author(s):  
Joanna Leśniewicz ◽  
◽  
Marcin Ferdynus ◽  
Danuta Wojterzak ◽  
Łukasz Banasiak ◽  
...  

After reaching old age, the elderly most often withdraw from social life. This is a serious problem because by isolating themselves from society they become less active. This has an impact on the emergence of many diseases related to both old age and the impact of physical inactivity on the body. The aim of the study was to present the consequences of the aging process in various aspects of the body’s functioning and the role of physical activity in eliminating these consequences. Unfortunately, there are still too few activities focused on physical activity for people over 65. This should change, because physical activity has a very positive effect on the human body and its well-being. Additionally, it can be observed that the earlier physical activity is started, the less changes in the body associated with the progressive aging process will occur. Such a person will be more agile and will not have major problems in dealing with overcoming the difficulties of everyday life.


Author(s):  
Grace C.H. Yang

The size and organization of collagen fibrils in the extracellular matrix is an important determinant of tissue structure and function. The synthesis and deposition of collagen involves multiple steps which begin within the cell and continue in the extracellular space. High-voltage electron microscopic studies of the chick embryo cornea and tendon suggested that the extracellular space is compartmentalized by the fibroblasts for the regulation of collagen fibril, bundle, and tissue specific macroaggregate formation. The purpose of this study is to gather direct evidence regarding the association of the fibroblast cell surface with newly formed collagen fibrils, and to define the role of the fibroblast in the control and the precise positioning of collagen fibrils, bundles, and macroaggregates during chick tendon development.


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