Influence of Riboxine, uridine, uridine-5'-monophosphate, and guanosine on experimental myocardial dystrophy

1985 ◽  
Vol 19 (6) ◽  
pp. 406-408
Author(s):  
V. E. Eliseev ◽  
V. V. Slobodskaya ◽  
G. I. Il'in ◽  
�. D. Kostin
Keyword(s):  
Myocardial Dystrophy

Treatment of ischemic heart disease in women during the pathological menopause

1982 ◽  
Vol 63 (3) ◽  
pp. 15-17
Author(s):  
E. V. Tsybulina ◽  
L. A. Emelyanova
Keyword(s):  
Coronary Artery Disease ◽  
Heart Disease ◽  
Comparative Analysis ◽  
Coronary Artery ◽  
Ischemic Heart Disease ◽  
Beta Blockers ◽  
Ischemic Heart ◽  
Myocardial Dystrophy ◽  
Artery Disease ◽  
Antianginal Drugs

A comparative analysis of the effectiveness of antianginal drugs (papaverine, persantine, intensain, nitrong, anaprilin) in combination with climacteric myocardial dystrophy in women was carried out. The data obtained make it possible to recommend beta-blockers (anaprilin, obzidan) for the treatment of coronary artery disease in women against the background of pathological menopause for wider use.

Effect of prostaglandin E2 on development of adrenalin-induced myocardial dystrophy

1988 ◽  
Vol 106 (5) ◽  
pp. 1528-1530
Author(s):  
E. A. Markova ◽  
I. R. Misula ◽  
Yu. M. Tsyapa
Keyword(s):  
Prostaglandin E2 ◽  
Myocardial Dystrophy

scholarly journals Dynamics of Changes in the Indicators of Mathematical Analysis of Heart Rate in Conditions of Adrenaline Myocardial Dystrophy against the Background of Different Functional Activity of the Pineal Gland

2021 ◽  
Vol 6 (6) ◽  
pp. 300-307
Author(s):  
L. D. Chebotar ◽  
◽  
O. M. Larycheva ◽  
H. V. Niepieina ◽  
M. M. Alieksieieva ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Pineal Gland ◽  
Functional State ◽  
Mathematical Analysis ◽  
High Efficiency ◽  
Regulatory Mechanisms ◽  
Stress Index ◽  
Corrective Effect ◽  
Myocardial Dystrophy

The purpose of the study was to examine the features of heart rate variability in experimental hyper- and hypofunction of the pineal gland, complicated by adrenal myocardial dystrophy. Materials and methods. To solve the set tasks, three models of functional states were created: hypo-, hyperfunction of the pineal gland, adrenaline myocardial dystrophy. Hypermelatoninemia was reproduced by administering melatonin. The hypofunction of the pineal gland was simulated by round-the-clock lighting. An experimental model of cardiac pathology, namely adrenaline myocardial dystrophy, was reproduced by administering adrenaline hydrochloride. The degree of tension of regulatory mechanisms and mechanisms of nervous regulation was assessed by mathematical analysis of heart rate variability. Results and discussion. The task of mathematical analysis is to extract “hidden information” and thereby assess the state and degree of tension of the regulatory mechanisms of the whole organism. According to the authors, mathematical analysis allows a differentiated approach to the assessment of regulatory effects, which is done by the nervous autonomic system, subcortical structures and the cerebral cortex. The data obtained by the authors suggest that the introduction of adrenaline in conditions of hypofunction of the pineal gland have cause-and-effect changes. These changes lead to disorders of autonomic regulation and possibly a trigger mechanism for a decrease in melatonin production by the pineal gland. Studies have shown that one of the advantages in conditions of hyperfunction of the pineal gland is the dominant role of parasympathetic processes in the mechanisms of adaptation of the heart to conditions of adrenal myocardial dystrophy. Timely and sufficient activation of melatonin provides a high efficiency of compensatory-adaptive changes and a positive role in increasing myocardial resistance. Conclusion. The results of the study showed that the dynamics of changes in the values of the indicators of the mathematical analysis of the heart rate in adrenal myocardial dystrophy against the background of hypo- and hyperfunction of the pineal gland revealed unidirectional changes. These changes are manifested in a decrease in heart rate, stress index and vegetative balance indicator. Consequently, the results obtained suggest that the introduction of melatonin against the background of adrenal myocardial dystrophy has a general corrective effect on the restoration of the functional state of the heart. Based on the results, the authors consider it appropriate to continue the study of the influence of various stressors on the functional state of the heart in conditions of different physiological activity of the pineal gland

Analysis of electrocardiosignals for formation of the diagnostic features of post-traumatic myocardial dystrophy

2017 ◽  
Vol 60 (9) ◽  
pp. 405-412
Author(s):  
N. G. Ivanushkina ◽  
K. O. Ivanko ◽  
Ye. S. Karplyuk ◽  
O. V. Chesnokova ◽  
I. A. Chaikovskiy ◽  
...  
Keyword(s):  
Diagnostic Features ◽  
Myocardial Dystrophy ◽  
Post Traumatic

scholarly journals Cardiac enzymes activity and lactate concentration in the blood of sport horses at myocardial dystrophy

2018 ◽  
Vol 20 (83) ◽  
pp. 162-167
Author(s):  
L. Slivinskа ◽  
I. Maksymovych ◽  
H. Tkachenko ◽  
A. Andriichuk ◽  
M. Leno
Keyword(s):  
Creatine Kinase ◽  
Blood Serum ◽  
Heart Muscle ◽  
Lactate Concentration ◽  
Myocardial Damage ◽  
Test Tube ◽  
Specific Marker ◽  
Average Intensity ◽  
Heart Muscle Cells ◽  
Myocardial Dystrophy

The article presents the results of research on the activity of cardiac specific enzymes and the concentration of lactate in the blood of sport horses for myocardial dystrophy of physical activity. Materials for researches were horses, used in the classical forms of equestrian sport of Ukrainian riding (n = 20), Hanoverian (n = 15) and Westphalian (n = 15) breeds. The average age of horses was 8.4 ± 0.71 years (3.5–16.0 g.), weight – 479.4 ± 8.54 kg (350–605 kg). Studies were conducted immediately before and immediately after exercise. The duration of regular training of average intensity was 1 hour: step 5 min; roaring lynx 10 minutes; step 5 min; training lynx 10 minutes; step 10 min; gallop with a transition to a step of 10 minutes; step 10 min. Blood samples from horses were taken from a jugular vein in a test tube without an anticoagulant (10 ml; Vacutest, Italy) and an anticoagulant (EDTA-K, 2.0 ml; Sarstedt, Germany). Diseases of the heart muscle are accompanied by the release of substances released from damaged cardiomyocytes, in particular, creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin. It has been established that the key to the pathogenesis of myocardial dystrophy in sport horses is the discrepancy between costs and energy recovery in the functioning structures of the heart muscle due to excessive cardiac load and significant increase in energy costs, as well as a disturbance in the balance of the electrolytes. Hyperlactatemia that occurs in horses during exercise causes changes in the permeability of cardiomyocytes and exit enzymes in the blood and can play a key role in the pathogenesis of myocardial dystrophy. Іn sporting horses, after activity in blood serum, activity of AST and LDH increases in blood serum, a tendency to increase activity of creatine kinase (CК) is observed. The cardiac isoenzyme CK (CK‒MB) was detected by a specific marker of myocardial dystrophy in sport horses, since its activity was likely to increase in the blood of all experimental groups of animals. A less specific marker of myocardial damage was the activity of hydroxybutyrate dehydrogenase (LDH‒1) in the blood, since the probable difference was established only in the Westphalian horses. Investigating the activity of AST, CK and CK-MB in horses can serve for differential diagnosis of rhabdomyolysis syndrome and damage to heart muscle cells, in particular for myocardial dystrophy.

scholarly journals Morphological changes in the conditions of adrenaline myocardial dystrophy against the background of the introduction of the compound PC-66 and amiodarone to rats

2020 ◽  
Vol 26 (1) ◽  
pp. 48-53
Author(s):  
O.V. Dzhyhaliuk ◽  
D.A. Lysenko ◽  
D.G. Smolko ◽  
I.M. Kyrychenko ◽  
S.V. Prokopenko
Keyword(s):  
Myocardial Infarction ◽  
Morphological Changes ◽  
Intraperitoneal Administration ◽  
Myocardial Damage ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Reference Drug ◽  
Myocardial Dystrophy ◽  
Destructive Processes

Adrenaline damage to the myocardium is an important element in the pathogenesis of myocardial infarction in humans. Despite the use of modern methods of treatment of myocardial infarction, the issue of cardioprotection of reperfusion myocardial damage remains open. Promising in this direction is the use of quinazolone derivatives, which have already shown cardioprotective properties in other models of myocardial infarction. The aim of the study was to establish morphological changes in the conditions of adrenaline myocardiodystrophy (AMD) against the background of the introduction of the compound PC-66 and amiodarone in rats. The study was performed on 100 nonlinear rats of both sexes weighing 165-220 g, divided into four groups of 25 animals each: 1 – intact rats; 2 – rats with a model of adrenaline myocardial infarction without treatment (control); 3 – rats with AMD treated with amiodarone (10 mg/kg, intraperitoneally); 4 – rats with AMD treated with compound PC-66 (10 mg/kg, intraperitoneally). It was found that control rats under conditions of cardiotoxic dose of adrenaline in the left ventricular myocardium for up to 8 days of the experiment does not fully restore the myocardial structure, dystrophic and necrobiotic changes were found in both cardiomyocytes and walls of vessels of a blood microcirculatory channel of a myocardium. Course intraperitoneal administration to rats of the compound PC-66 in the conditions of adrenaline myocardial infarction as well as amiodarone, contributes to the attenuation of signs of dystrophic and destructive processes. The degree of protective effect on the myocardium under conditions of cardiotoxic dose of adrenaline compound PC-66 was not lower to the reference drug – amiodarone. Thus, it is morphologically confirmed that in adrenaline myocardial infarction the compound PC-66, similar to the action of amiodarone, has a cardioprotective effect.

scholarly journals Infectious hepatitis in dogs (state of the problem)

2019 ◽  
pp. 16-21
Author(s):  
G. Zon ◽  
L. Ivanovska ◽  
I. Zon
Keyword(s):  
Clinical Signs ◽  
Infectious Hepatitis ◽  
Study Data ◽  
The Body ◽  
Regional Lymph Nodes ◽  
Current State ◽  
Myocardial Dystrophy ◽  
Multiple Blood ◽  
State Of Research ◽  
Test Use

The paper contains data regarding current state of research and author opinion on realization of diagnostics and therapy improvement in case of infectious hepatitis in dogs based on the form of the disease. A study of worldwide practice and a summary of personal experience of the aspects of clinical manifestation, diagnostics and treatment methods for canine hepatitis have been performed. According to our research canine infectious hepatitis in Sumy region is usually found in dogs at 1-3 (44%) years of age, less of ten at 5-8 (28%) years. The quantity of cases at 3-8 y.o. is 17% and in animals younger than  1 year – 11%. After being introduced into the body, the virus replicates in the regional lymph nodes then appears in the blood (viremia), after 2-3 days it forms masses of core inclusions (Rubart’s bodies) – big, round, acidophilic masses in capillary and vein endothelium in all the organs, especially liver and spleen. As a result liver dystrophy occurs and general body intoxication follows. Further development of the process results in renal and myocardial dystrophy,appearance of multiple blood effusions on mucous and serous membranes. After the neural centers of the brain and spine are being affected the locomotion disorders are observed.At the stage of acute clinical signs the virus is present in blood and all the exudates, while being observed only in kidneys and urine later. The incubation period of spontaneous hepatitis lasts about 6 to 9 days. Currently there are some cases of an acute and peracute course but chronic and latent courses are prevalent. The organ lesions depend on the severity and course of the disease. Infectious hepatitis is being diagnosed based on epizootological, clinical, pathological and laboratory study data as well as virological research and biological test. Use of a treatment regimen including polyvalent serum, anfluron, cobactan, difeniramine, metoclopramide, furosemide, hepavikel, and crystalline IV solutions allowed shorteningofthe treatment period in comparison to average.

Sign in / Sign up

Export Citation Format

Share Document