Computer analysis of a file of psychotropically active compounds. V. relationship between test results for experimental animals and model enzyme systems

1983 ◽  
Vol 17 (8) ◽  
pp. 579-581
Author(s):  
L. A. Leksina ◽  
A. S. Kabankin ◽  
�. F. Lavretskaya ◽  
M. A. Landau ◽  
P. N. Baldenkov
Keyword(s):  
Computer Analysis ◽  
Test Results ◽  
Active Compounds ◽  
Experimental Animals ◽  
Enzyme Systems

Glutaraldehyde Nonbiologic Monitors

1990 ◽  
Vol 11 (8) ◽  
pp. 439-442 ◽  
Author(s):  
Donald J. Kleier ◽  
Robert E. Averbach
Keyword(s):  
Bacterial Cell ◽  
Contact Time ◽  
Cell Membranes ◽  
Test Results ◽  
Chemical Solution ◽  
Enzyme Systems ◽  
Prolonged Contact ◽  
Free Aldehyde ◽  
Aldehyde Groups ◽  
Bacterial Type

Glutaraldehyde was first synthesized by Harries and Tank in 1908, and first marketed as a chemosterilizer in 1963. Since that time, glutaraldehyde has been used extensively as a disinfectant and chemical sterilizing solution. Even though it is generally agreed that moist heat is the preferred method of sterilization for medical, dental and hospital instruments, glutaraldehyde is a relatively safe, simple-to-use and effective chemical solution that can sterilize heat-sensitive materials.Glutaraldehyde (1,5-pentanedial) has two free aldehyde groups that combine irreversibly with bacterial cell membranes and enzyme systems. These properties give glutaraldehyde its biocidal effect. Contact time with glutaraldehyde is critical if sterilization, rather than disinfection, is to be achieved. Sterilization time ranges from minutes to ten hours, depending upon bacterial type and conditions of the test results. Sterilization with glutaraldehyde solutions usually requires prolonged contact times. Manufacturer instructions must be strictly followed.

Computer analysis of a file of psychotropically active compounds. IV. Extremal Parameter Grouping

1983 ◽  
Vol 17 (8) ◽  
pp. 575-578
Author(s):  
A. A. Plotkin ◽  
I. B. Muchnik ◽  
A. S. Kabankin ◽  
N. E. Kiseleva ◽  
�. F. Lavretskaya ◽  
...  
Keyword(s):  
Computer Analysis ◽  
Active Compounds ◽  
Extremal Parameter

scholarly journals STUDY OF THE KINETICS OF ENZYMATIC OXIDATION OF 2,3,6-TRIMETHYLPHENOL IN THE PRESENCE OF IMMOBILIZED PEROXIDASE

2020 ◽  
pp. 7-15
Author(s):  
Ольга Валентиновна Гребенникова ◽  
Александрина Михайловна Сульман ◽  
Владимир Петрович Молчанов ◽  
Елена Михайловна Михайлова ◽  
Ирина Павловна Шкилева ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Vitamin E ◽  
Magnetic Nanoparticles ◽  
Biologically Active ◽  
Enzymatic Oxidation ◽  
Stable Operation ◽  
Substituted Phenols ◽  
Active Compounds ◽  
Enzyme Systems ◽  
Kinetics Of

В работе изучался процесс окисления 2,3,6-триметилфенола в присутствии иммобилизованной пероксидазы корня хрена. В результате такого окисления был получен полупродукт витамина Е (2,3,5-триметилгидрохинон). Иммобилизация фермента проводилась на магнитные наночастицы, на SiO и AlO. Все исследованные биокатализаторы показали стабильную работу в процессе окисления 2,3,6-триметилфенола с помощью пероксида водорода. Таким образом, синтезированные биокаталитические ферментные системы могут успешно применяться в качестве альтернативных катализаторов окисления замещенных фенолов с целью получения биологически активных соединений класса витаминов. We studied the oxidation of 2,3,6-trimethylphenol in the presence of immobilized horseradish root peroxidase. As a result of this oxidation, a semi-product of vitamin E (2,3,5-trimethylhydroquinone) was obtained. The enzyme was immobilized on magnetic nanoparticles, on SiO and AlO. All the studied biocatalysts showed stable operation during the oxidation of 2,3,6-trimethylphenol using hydrogen peroxide. Thus, the synthesized biocatalytic enzyme systems can be successfully used as alternative catalysts for the oxidation of substituted phenols in order to obtain biologically active compounds of the vitamin class.

scholarly journals PEMANFAATAN EKSTRAK BUNGA KECOMBRANG (Etlingera elatior jack R.M.sm) SEBAGAI LARVASIDA NYAMUK (Culex quinquifasciatus Say)

2020 ◽  
Vol 10 ◽  
pp. 44-49
Author(s):  
Indra Rahmawati ◽  
Bagus Uda Palgunadi ◽  
Lailia Dwi Kusuma Wardhani ◽  
Ni Made Dewi Lestari
Keyword(s):  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Mosquito Larvae ◽  
Test Results ◽  
Experimental Animals ◽  
Flower Extract ◽  
The One ◽  
One Way Anova ◽  
Etlingera Elatior

This study aims to determine the effectiveness of kecombrang flower extract (Etlingera elatior jack R.M.sm) on the death of Culex quenquefasciatus Say larvae. Experimental animals used were Culex quenquefasciatus Say larvae, amounting to 625 tails. The design used was a randomized complete design with 5 treatments and 5 replications. The five treatments consisted of two test groups, namely the treatment group consisting of concentrations of 5%, 10%, 15%, and the control group consisting of positive control namely abate and negative control namely aquades. Observation of mosquito larvae death was done every 2 hours for 12 hours. The data obtained were analyzed using the one-way ANOVA test and continued with the Duncan test. Based on the results of the one way ANOVA calculation the value of sig.0.00 <0.05 means that there are significant differences between treatments. Duncan test results on the treatment of 10% and 15% kecombrang flower extract have the ability as a larvicide high and equal to positive control (abate). Based on the results of the study it was concluded that the extract of kecombrang flower (Etlingera elatior jack R.M.sm) had the ability to larvae against the Culex quenquefasciatus Say mosquito.

Study of Active Compounds from Red Cabbage (Brassica oleracea var. capitata f. Rubra) Extract as a Green Corrosion Inhibitor for API 5L Grade X60 Steel in NaCl 3.5% Environment

2016 ◽  
Vol 842 ◽  
pp. 24-30 ◽  
Author(s):  
Andi Rustandi ◽  
M. Akbar Barrinaya
Keyword(s):  
Corrosion Inhibitor ◽  
Adsorption Mechanism ◽  
Electrochemical Impedance ◽  
Test Results ◽  
Active Compounds ◽  
Red Cabbage ◽  
Tafel Polarization ◽  
Green Corrosion Inhibitor ◽  
Polarization Test ◽  
Cabbage Extract

Red cabbage extract has been investigated in this work whether it would perform as a green corrosion inhibitor for API 5L grade X60 steel in 3.5% NaCl environment. Based on the FTIR and LC-MS analysis the active compounds of corrosion inibitor were hydroxyl, carbonyl and cyanidin. The Tafel polarization test results showed that red cabbage extract performed as a mixed corrosion inhibitor and the Electrochemical Impedance Spectroscopy test results showed that the impedance, polarization resistance and capacitive resistance of steel surface increased with the addition of red cabbage corrosion inhibitor. Based on evaluation of the testing results red extract red cabbage performed significant corrosion inhibition effect. The inhibitor efficiency increases with increased corrosion inhibitor concentration and the optimum inhibitor percent efficiency achieved 81%. The adsorption mechanism of red cabbage corrosion inhibitor can be considered as a Langmuir Isotherm

scholarly journals UJI FITOKIMIA DAN PENENTUAN Inhibition Concentration 50% PADA BEBERAPA TUMBUHAN OBAT DI PULAU TIDORE

2014 ◽  
Vol 14 (2) ◽  
pp. 95
Author(s):  
Wiwin Abdullah ◽  
Max Revolta J. Runtuwene ◽  
Vanda Selvana Kamu
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants ◽  
Leaf Extract ◽  
Ethanol Extract ◽  
Seed Extract ◽  
Test Results ◽  
Active Compounds ◽  
Inhibition Concentration ◽  
Dpph Method ◽  
Ic50 Values

ABSTRAK Penelitian ini dilakukan untuk mengetahui senyawa aktif yang terkandung melalui pengujian fitokimia dan aktivitas antioksidan pada tumbuhan obat di pulau Tidore. Uji aktivitas antioksidan menggunakan metode DPPH dilanjutkan dengan perhitungan Inhibition Concentration 50% (IC50). Hasil yang diperoleh adalah biji buah mojoi terkandung senyawa alkaloid dan saponin, buah coro terkandung alkaloid, flavonoid, dan saponin, pada daun ofo terkandung  alkaloid, tanin, flavonoid, steroid, dan saponin dan pada rimpang kuso mafola terkandung alkaloid, tanin, flavonoid, steroid, dan saponin. Nilai IC50 sebagai berikut biji rimpang kuso mafola 37,30 ppm, buah coro 250,17 ppm, daun ofo 976,10 ppm  dan buah mojoi 1001, 07 ppm. Kata kunci :Tumbuhan  obat, DPPH, antioksidan dan uji fitokimia. PHYTOCHEMICALS TEST AND DETERMINATION Inhibition Concentration 50% ON SOME MEDICINAL PLANTS IN THE TIDORE ISLAND ABSTRACT This study was conducted to determine the active compounds contained in an assessment of phytochemical and antioxidant activity in the medicinal plants of Tidore island. The test antioxidant activity was used DPPH method. In the test results to the phytochemical , that mojoi fruit seeds contained alkaloids and saponins, fruit coro (alkaloids, flavonoids, and saponins), ofo leaves (alkaloids, tannins, flavonoids, steroids, and saponins) and ethanol extract of rhizome kusomafola (alkaloids, tannins, flavonoids, steroids, and saponins. In  calculation of IC50 values ​​for rhizome kusomafola 37.30 ppm, 250.17 ppm coro fruit, 976.10 ppm ofo leaf extract, and fruit seed extract mojoi 1001.07 ppm. Keywords: Medicinal plants, DPPH, antioxidant and phytochemical test.

scholarly journals IDENTIFICATION AND ANALYSIS OF ACTIVE CAROTENOID COMPOUNDS FROM ENTAWAK FRUIT (ARTOCARPUS ANISOPHYLLUS)

2021 ◽  
Vol 8 (2) ◽  
pp. 136
Author(s):  
Gervacia Jenny Ratnawaty ◽  
Ratih Indrawati ◽  
Jajar Pramata Syari
Keyword(s):  
Extraction Process ◽  
Carotenoid Content ◽  
Carotenoid Pigments ◽  
Test Results ◽  
Total Carotenoid ◽  
Phytochemical Screening ◽  
Isolation And Identification ◽  
Active Compounds ◽  
Total Carotenoid Content ◽  
Chromatographic Profile

— Isolation and identification of active compounds from mentawak fruit (Artocarpus Anisophyllus) used a plant determination test to determine the plant content. Furthermore, the extraction process was carried out to obtain a crude extract of carotenoid pigments by maceration method using n-hexane as solvent. Furthermore, the obtained macerate was carried out by phytochemical tests to determine the content of the active compounds. The TLC test was carried out to confirm the presence of a positive group of compounds on phytochemical screening, and to determine the chromatographic profile of the extract.  The identification results showed that the phytochemicals showed that the active compounds contained in macerate were alkaloids, flavonoids, tannins and saponins. The KLT test results obtained an Rf value of 0.875. While the total carotenoid content using a spectrophotometer UV-Vis is 958 µg/ml.

Kinetics of homeostatic behavior of receptor–enzyme systems under the action of physiologically active compounds

Biosystems ◽  
1998 ◽  
Vol 45 (1) ◽  
pp. 77-85
Author(s):  
Anna D. Ilyina ◽  
Sergei V. Zaitsev ◽  
Irina A. Grishina ◽  
Sergei D. Varfolomeev
Keyword(s):  
Active Compounds ◽  
Enzyme Systems ◽  
Kinetics Of ◽  
Physiologically Active Compounds

scholarly journals Identification of Active Compounds Calotropis gigantea Stem Extracts as Antimalarials Agents on Animal Infected Plasmodium berghei

2016 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Muhammad Shofiyullah ◽  
Ro’ihatul Muti'ah ◽  
Elok Kamilah Hayati ◽  
Chrystiaji Indradmojo
Keyword(s):  
Active Compound ◽  
Plasmodium Berghei ◽  
Antimalarial Activity ◽  
Ethanol Extract ◽  
Wild Plant ◽  
Test Results ◽  
Experimental Animals ◽  
Tukey Test ◽  
Rf Values ◽  
Layer Chromatography

<p><span lang="EN-US">Thistle <em>(Calotropisgigantea)</em> is a wild plant that contains secondary metabolites as a potential antimalarial drugs.</span><span lang="EN-US">This study aims to determine the content of active compound contained, the potential of ethanol extract of the stem thistle as an antimalarial, and knowing the best eluent used when TLC test.</span><span lang="EN-US">This study covers the extraction of stem thistle using maceration for 24 hours using ethanol 80%.Stirring assisted with <em>shaker</em> for 3 hours. Ekstrak concentrated phytochemical test, antimalarial activity was evaluated by experimental animals mice infected <em>by Plasmodium berghei</em>.</span><span lang="EN-US">Data degree of parasitaemia in mice were analyzed using Minitab 16 with Test <em>TwoWay</em> ANOVA followed by Tukey test.</span><span lang="EN-US">The results showed that ethanol extract stem thistle contains the active compound class of triterpenoids, and potentially as an antimalarial with ED<sub>50</sub> values 152.878 mg / kg bw were included in both categories.</span><span lang="EN-US">TLC test results showed that the best eluent for the separation of triterpenoids of stem thistle extract is benzene: chloroform (3: 7) which produced 12 spots with Rf values of 0.04;0.06;0.14;0.21;0.29;0.35;0.41;0.48;0.80;0.84;0.88;0.91.</span></p><p><span lang="EN-US"> </span></p><p><strong><span lang="EN-US">Keywords: </span></strong><span lang="EN-US">Antimalarial, Calotropisgigantea</span><span lang="EN-US">, Ethanol 80%, Plasmodium berghei</span><span lang="EN-US">, Thin Layer Chromatography</span></p>

Computer Analysis of Antimicrobial Sensitivity Test Results a Preliminary Study

1973 ◽  
Vol 18 (2) ◽  
pp. 59-62 ◽  
Author(s):  
J. Hulbert
Keyword(s):  
General Hospital ◽  
Computer Analysis ◽  
Sensitivity Test ◽  
Flow Chart ◽  
Test Results ◽  
Antimicrobial Sensitivity ◽  
Preliminary Study ◽  
Antimicrobial Sensitivity Test

A system for the computer analysis of antimicrobial sensisivity test results is described, and the computer flow-chart is illustrated. Its purpose is to detect, among strains of bacteria isolated from clinical sources, the emergence of linked resistance to several antibiotics, and to study its development. It is considered that this information will be useful to clinicians, and indispensable for those responsible for the formulation of general hospital antibiotic policies.

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