Mitochondrial creatine kinase activity in patients with disturbed energy generation in muscle mitochondria

1994 ◽  
Vol 17 (1) ◽  
pp. 67-73 ◽  
Author(s):  
J. Smeitink ◽  
W. Ruitenbeek ◽  
R. Sengers ◽  
R. Wevers ◽  
T. v. Lith ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Kinase Activity ◽  
Energy Generation ◽  
Creatine Kinase Activity ◽  
Mitochondrial Creatine Kinase ◽  
Muscle Mitochondria

scholarly journals Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle

2012 ◽  
Vol 590 (21) ◽  
pp. 5475-5486 ◽  
Author(s):  
Christopher G. R. Perry ◽  
Daniel A. Kane ◽  
Eric A. F. Herbst ◽  
Kazutaka Mukai ◽  
Daniel S. Lark ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Human Skeletal Muscle ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Mitochondrial Creatine Kinase

scholarly journals Mitochondrial Creatine Kinase Activity Prevents Reactive Oxygen Species Generation

2006 ◽  
Vol 281 (49) ◽  
pp. 37361-37371 ◽  
Author(s):  
Laudiene Evangelista Meyer ◽  
Lilia Bender Machado ◽  
Ana Paula S. A. Santiago ◽  
Wagner Seixas da-Silva ◽  
Fernanda G. De Felice ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Creatine Kinase ◽  
Kinase Activity ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Creatine Kinase Activity ◽  
Oxygen Species ◽  
Mitochondrial Creatine Kinase

Impact of myocardial inflammation on cytosolic and mitochondrial creatine kinase activity and expression

2009 ◽  
Vol 104 (3) ◽  
pp. 247-257 ◽  
Author(s):  
Linda Ebermann ◽  
Cornelia Piper ◽  
Uwe Kühl ◽  
Karin Klingel ◽  
Uwe Schlattner ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Myocardial Inflammation ◽  
Mitochondrial Creatine Kinase

scholarly journals Increased serum mitochondrial creatine kinase activity as a risk for hepatocarcinogenesis in chronic hepatitis C patients

2014 ◽  
Vol 135 (4) ◽  
pp. 871-879 ◽  
Author(s):  
Kenichiro Enooku ◽  
Hayato Nakagawa ◽  
Yoko Soroida ◽  
Ryunosuke Ohkawa ◽  
Yuko Kageyama ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Mitochondrial Creatine Kinase ◽  
Chronic Hepatitis C Patients

Loose-coupled mitochondria in chronic glucagon-treated hyperthermic ducklings

1989 ◽  
Vol 256 (6) ◽  
pp. R1192-R1199 ◽  
Author(s):  
H. Barre ◽  
G. Berne ◽  
P. Brebion ◽  
F. Cohen-Adad ◽  
J. L. Rouanet
Keyword(s):  
Creatine Kinase ◽  
Cytochrome Oxidase ◽  
Oxidase Activity ◽  
Kinase Activity ◽  
Mitochondrial Protein ◽  
Creatine Kinase Activity ◽  
Strong Increase ◽  
Muscle Mitochondria ◽  
Glucagon Test ◽  
Cytochrome Oxidase Activity

In chronic glucagon-treated ducklings (GT) showing thermogenic and hyperthermic responses without shivering to glucagon test injection and in control ducklings (TN; both aged 44 +/- 1 days and reared at thermoneutrality), subsarcolemmal (S) and intermyofibrillar (I) mitochondria from gastrocnemius muscle and mitochondria from liver were isolated. Respiration and cytochrome oxidase activity were determined in these isolated mitochondria by polarography and creatine kinase activity by spectrophotometry, both at 25 degrees C. In GT ducklings, the powerful thermogenesis observed in vivo after a glucagon test injection may be due to the uncoupling effect of released free fatty acids (FFA) in loose-coupled mitochondria because their respiration increased as a function of FFA concentration, and the loose coupling of these mitochondria was reversed by addition of albumin. In all types of mitochondria from GT ducklings, the increase in respiration because of FFA was about double that in mitochondria from controls. There was no change in creatine kinase activity from liver and I mitochondria, but a 16% decrease in this enzyme activity (expressed per mg mitochondrial protein) from S mitochondria was shown despite a strong increase in cytochrome oxidase activity from liver mitochondria (+114% if expressed per g tissue) and from muscle mitochondria (I, +53 or +48%; S, +41 or +97% if expressed per mg mitochondrial protein or per g tissue, respectively). These results support a coupling defect in liver and skeletal muscle mitochondria from the GT hyperthermic ducklings and an uncoupling reinforcement by FFA.

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