Maintained Coupling of Oxidative Phosphorylation to Creatine Kinase Activity in Sarcomeric Mitochondrial Creatine Kinase-deficient Mice

1998 ◽  
Vol 30 (5) ◽  
pp. 901-912 ◽  
Author(s):  
E Boehm
Keyword(s):  
Creatine Kinase ◽  
Oxidative Phosphorylation ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Mitochondrial Creatine Kinase ◽  
Deficient Mice

scholarly journals Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle

2012 ◽  
Vol 590 (21) ◽  
pp. 5475-5486 ◽  
Author(s):  
Christopher G. R. Perry ◽  
Daniel A. Kane ◽  
Eric A. F. Herbst ◽  
Kazutaka Mukai ◽  
Daniel S. Lark ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Human Skeletal Muscle ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Mitochondrial Creatine Kinase

scholarly journals Mitochondrial Creatine Kinase Activity Prevents Reactive Oxygen Species Generation

2006 ◽  
Vol 281 (49) ◽  
pp. 37361-37371 ◽  
Author(s):  
Laudiene Evangelista Meyer ◽  
Lilia Bender Machado ◽  
Ana Paula S. A. Santiago ◽  
Wagner Seixas da-Silva ◽  
Fernanda G. De Felice ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Creatine Kinase ◽  
Kinase Activity ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Creatine Kinase Activity ◽  
Oxygen Species ◽  
Mitochondrial Creatine Kinase

Impact of myocardial inflammation on cytosolic and mitochondrial creatine kinase activity and expression

2009 ◽  
Vol 104 (3) ◽  
pp. 247-257 ◽  
Author(s):  
Linda Ebermann ◽  
Cornelia Piper ◽  
Uwe Kühl ◽  
Karin Klingel ◽  
Uwe Schlattner ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Myocardial Inflammation ◽  
Mitochondrial Creatine Kinase

scholarly journals Alterations of skeletal muscle bioenergetics in a mouse with F508del mutation leading to a cystic fibrosis-like condition

2019 ◽  
Vol 317 (2) ◽  
pp. E327-E336
Author(s):  
Nicola Lai ◽  
Chinna Kummitha ◽  
Mitchell Drumm ◽  
Charles Hoppel
Keyword(s):  
Skeletal Muscle ◽  
Cystic Fibrosis ◽  
Creatine Kinase ◽  
Electron Transport ◽  
Oxidative Phosphorylation ◽  
Aerobic Capacity ◽  
Electron Transport Chain ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Transport Chain

High energy expenditure is reported in cystic fibrosis (CF) animal models and patients. Alterations in skeletal muscle oxidative capacity, fuel utilization, and the creatine kinase-phosphocreatine system suggest mitochondrial dysfunction. Studies were performed on congenic C57BL/6J and F508del ( Cftrtm1kth) mice. Indirect calorimetry was used to measure gas exchange to evaluate aerobic capacity during treadmill exercise. The bioenergetic function of skeletal muscle subsarcolemmal (SSM) and interfibrillar mitochondria (IFM) was evaluated using an integrated approach combining measurement of the rate of oxidative phosphorylation by polarography and of electron transport chain activities by spectrophotometry. CF mice have reduced maximal aerobic capacity. In SSM of these mice, oxidative phosphorylation was impaired in the presence of complex I, II, III, and IV substrates except when glutamate was used as substrate. This impairment appeared to be caused by a defect in complex V activity, whereas the oxidative system of the electron transport chain was unchanged. In IFM, oxidative phosphorylation and electron transport chain activities were preserved, whereas complex V activity was reduced, in CF. Furthermore, creatine kinase activity was reduced in both SSM and IFM of CF skeletal muscle. The decreased complex V activity in SSM resulted in reduced oxidative phosphorylation, which could explain the reduced skeletal muscle response to exercise in CF mice. The decrease in mitochondrial creatine kinase activity also contributed to this poor exercise response.

scholarly journals Increased serum mitochondrial creatine kinase activity as a risk for hepatocarcinogenesis in chronic hepatitis C patients

2014 ◽  
Vol 135 (4) ◽  
pp. 871-879 ◽  
Author(s):  
Kenichiro Enooku ◽  
Hayato Nakagawa ◽  
Yoko Soroida ◽  
Ryunosuke Ohkawa ◽  
Yuko Kageyama ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Mitochondrial Creatine Kinase ◽  
Chronic Hepatitis C Patients
Sign in / Sign up

Export Citation Format

Share Document