Regulation of adrenocorticosteroid receptor mRNA expression in the central nervous system

1993 ◽  
Vol 13 (4) ◽  
pp. 349-372 ◽  
Author(s):  
James P. Herman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mrna Expression ◽  
Receptor Mrna ◽  
The Central Nervous System

Opioid receptor and peptide mRNA expression in proliferative zones of fetal rat central nervous system

1998 ◽  
Vol 76 (3) ◽  
pp. 284-293 ◽  
Author(s):  
Frances M Leslie ◽  
Yiling Chen ◽  
Ursula H Winzer-Serhan
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Mrna Expression ◽  
Nervous System Development ◽  
Endogenous Opioids ◽  
Receptor Mrna ◽  
Fetal Rat ◽  
Kappa Receptor ◽  
Proenkephalin Mrna

There is increasing evidence to suggest that opioid peptides may have widespread effects as regulators of growth. To evaluate the hypothesis that endogenous opioids control cellular proliferation during neural development, we have used in situ hybridization to examine opioid peptide and receptor mRNA expression in neuroepithelial zones of fetal rat brain and spinal cord. Our data show that proenkephalin mRNA is widely expressed in forebrain germinal zones and choroid plexus during the second half of gestation. In contrast, prodynorphin mRNA expression is restricted to the periventricular region of the ventral spinal cord. Little µ or delta receptor mRNA expression was detected in any regions of neuronal proliferation prior to birth. However, kappa receptor mRNA is widely expressed in hindbrain germinal zones during the 3rd week of gestation. Our present findings support the hypothesis that endogenous opioids may regulate proliferation of both neuronal and non-neuronal cells during central nervous system development. Given the segregated expression of proenkephalin mRNA in forebrain neuroepithelium and kappa receptor mRNA within hindbrain, different opioid mechanisms may regulate cell division in rostral and caudal brain regions.Key words: enkephalin, dynorphin, ontogeny, neurogenesis.

scholarly journals Thyrotrophin-releasing hormone receptor 1 and prothyrotrophin-releasing hormone mRNA expression in the central nervous system are regulated by suckling in lactating rats

2005 ◽  
Vol 152 (5) ◽  
pp. 791-803 ◽  
Author(s):  
Åse-Karine Fjeldheim ◽  
Per Ivar Høvring ◽  
Ole-Petter Løseth ◽  
Per Wiik Johansen ◽  
Joel C Glover ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mrna Expression ◽  
Physiological Role ◽  
Plasma Prolactin ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
The Central Nervous System ◽  
Plasma Prl

Background: The accepted function of the hypothalamic peptide, thyrotrophin-releasing hormone (TRH), is to initiate release of thyrotrophin (TSH) from the pituitary. A physiological role for TRH in lactating rats has not yet been established. Methods: Tissues were prepared from random-cycling and lactating rats and analysed using Northern blot, real time RT-PCR and quantitative in situ hybridisation. Results: This study demonstrates that TRH receptor 1 (TRHR1) mRNA expression is up-regulated in the pituitary and in discrete nuclei of the hypothalamus in lactating rats, while proTRH mRNA expression levels are increased only in the hypothalamus. The results were corroborated by quantitative in situ analysis of proTRH and TRHR1. Bromocriptine, which reduced prolactin (PRL) concentrations in plasma of lactating and nursing rats, also counteracted the suckling-induced increase in TRHR1 mRNA expression in the hypothalamus, but had an opposite effect in the pituitary. These changes were confined to the hypothalamus and the amygdala in the brain. Conclusions: The present study shows that the mechanisms of suckling-induced lactation involve region-specific regulation of TRHR1 and proTRH mRNAs in the central nervous system notably at the hypothalamic level. The results demonstrate that continued suckling is critical to maintain plasma prolactin (PRL) levels as well as proTRH and TRHR1 mRNA expression in the hypothalamus. Increased plasma PRL levels may have a positive modulatory role on the proTRH/TRHR1 system during suckling.

scholarly journals Kinetics of Cytokine mRNA Expression in the Central Nervous System Following Lethal and Nonlethal Coronavirus-Induced Acute Encephalomyelitis

Virology ◽  
1997 ◽  
Vol 233 (2) ◽  
pp. 260-270 ◽  
Author(s):  
Beatriz Parra ◽  
David R. Hinton ◽  
Mark T. Lin ◽  
Daniel J. Cua ◽  
Stephen A. Stohlman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mrna Expression ◽  
Cytokine Mrna ◽  
Cytokine Mrna Expression ◽  
The Central Nervous System ◽  
Kinetics Of

Prolyl endopeptidase mRNA expression in the central nervous system during rat development

2010 ◽  
Vol 40 (1) ◽  
pp. 53-62 ◽  
Author(s):  
N. Agirregoitia ◽  
P. Bizet ◽  
E. Agirregoitia ◽  
I. Boutelet ◽  
L. Peralta ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mrna Expression ◽  
Prolyl Endopeptidase ◽  
Rat Development ◽  
The Central Nervous System
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