Loss of intracortical myelinated fibers: A distinctive age-related alteration in the human striate area

1983 ◽  
Vol 61 (3-4) ◽  
pp. 178-182 ◽  
Author(s):  
P. Lintl ◽  
H. Braak
Keyword(s):  
Myelinated Fibers ◽  
Age Related ◽  
Striate Area

Age-related changes of the myelinated fibers in the human corticospinal tract: a quantitative analysis

1994 ◽  
Vol 88 (2) ◽  
pp. 137-142 ◽  
Author(s):  
Shin-ichi Terao ◽  
G. Sobue ◽  
Yoshio Hashizume ◽  
Noriko Shimada ◽  
Terunori Mitsuma
Keyword(s):  
Quantitative Analysis ◽  
Corticospinal Tract ◽  
Myelinated Fibers ◽  
Age Related ◽  
Age Related Changes

Age related changes in the myelinated fibers of corpus callosum

2011 ◽  
Vol 499 (3) ◽  
pp. 208-212 ◽  
Author(s):  
Qiang Xu ◽  
Wei Lu ◽  
Xuan Qiu ◽  
Shu Yang ◽  
Chen Li ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Myelinated Fibers ◽  
Age Related ◽  
Age Related Changes

Stereological investigation of age-related changes of myelinated fibers in the rat cortex

2009 ◽  
Vol 87 (13) ◽  
pp. 2872-2880 ◽  
Author(s):  
Wei Zhang ◽  
Shu Yang ◽  
Chen Li ◽  
Lin Chen ◽  
Yong Tang
Keyword(s):  
Rat Cortex ◽  
Myelinated Fibers ◽  
Age Related ◽  
Stereological Investigation ◽  
Age Related Changes

Different patterns in age‐related morphometric alteration of myelinated fibers and capillaries of the tibial nerve: a longitudinal study in normal rats

2020 ◽  
Vol 236 (6) ◽  
pp. 1101-1111
Author(s):  
Masahiro Sakita ◽  
Shinichiro Murakami ◽  
Koji Nonaka ◽  
Ryuji Sakamoto ◽  
Takafumi Saito ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Tibial Nerve ◽  
Myelinated Fibers ◽  
Age Related

Age-related changes of the myelinated fibers in the human corticospinal tract: a quantitative analysis

1994 ◽  
Vol 88 (2) ◽  
pp. 137-142 ◽  
Author(s):  
Shin-ichi Terao ◽  
Gen Sobue ◽  
Yoshio Hashizume ◽  
Noriko Shimada ◽  
Terunori Mitsuma
Keyword(s):  
Quantitative Analysis ◽  
Corticospinal Tract ◽  
Myelinated Fibers ◽  
Age Related ◽  
Age Related Changes

Stereological quantification of age-related changes in myelinated fibers of rat white matter

Neuroreport ◽  
2017 ◽  
Vol 28 (1) ◽  
pp. 42-49 ◽  
Author(s):  
Chen Li ◽  
Lei Zhang ◽  
Fenglei Chao ◽  
Qian Xiao ◽  
Yanmin Luo ◽  
...  
Keyword(s):  
White Matter ◽  
Myelinated Fibers ◽  
Age Related ◽  
Age Related Changes

Stereological Investigation of the Age-Related Changes of the Myelinated Fibers in the Hippocampus of Male Rats

2014 ◽  
Vol 297 (8) ◽  
pp. 1490-1497 ◽  
Author(s):  
Wei Lu ◽  
Shu Yang ◽  
Lin Chen ◽  
Xuan Qiu ◽  
Chun-Xia Huang ◽  
...  
Keyword(s):  
Male Rats ◽  
Myelinated Fibers ◽  
Age Related ◽  
Stereological Investigation ◽  
Age Related Changes

Spindle shaped bodies in foveolar cones of the baboon retina

1989 ◽  
Vol 47 ◽  
pp. 960-961
Author(s):  
W. Krebs ◽  
I. Krebs
Keyword(s):  
Cross Sections ◽  
Inclusion Bodies ◽  
Photoreceptor Cells ◽  
Papio Anubis ◽  
Retinal Photoreceptor ◽  
Age Related ◽  
Cone Cells ◽  
Membrane Bound ◽  
Oriented Parallel ◽  
Shaped Inclusion

Various inclusion bodies occur in vertebrate retinal photoreceptor cells. Most of them are membrane bound and associated with phagocytosis or they are age related residual bodies. We found an additional inclusion body in foveal cone cells of the baboon (Papio anubis) retina.The eyes of a 15 year old baboon were fixed by immersion in cacodylate buffered glutaraldehyde (2%)/formaldehyde (2%) as described in detail elsewhere . Pieces of retina from various locations, including the fovea, were embedded in epoxy resin such that radial or tangential sections could be cut.Spindle shaped inclusion bodies were found in the cytoplasm of only foveal cones. They were abundant in the inner segments, close to the external limiting membrane (Fig. 1). But they also occurred in the outer fibers, the perikarya, and the inner fibers (Henle’s fibers) of the cone cells. The bodies were between 0.5 and 2 μm long. Their central diameter was 0.2 to 0. 3 μm. They always were oriented parallel to the long axis of the cone cells. In longitudinal sections (Figs. 2,3) they seemed to have a fibrous skeleton that, in cross sections, turned out to consist of plate-like (Fig.4) and tubular profiles (Fig. 5).

Autophagy and ageing: implications for age-related neurodegenerative diseases

2013 ◽  
Vol 55 ◽  
pp. 119-131 ◽  
Author(s):  
Bernadette Carroll ◽  
Graeme Hewitt ◽  
Viktor I. Korolchuk
Keyword(s):  
Neurodegenerative Diseases ◽  
Energy Availability ◽  
Future Studies ◽  
Intracellular Degradation ◽  
Age Related ◽  
Autophagy Induction ◽  
Social Importance ◽  
Cellular Dysfunction ◽  
Autophagy Activity ◽  
Intense Research

Autophagy is a process of lysosome-dependent intracellular degradation that participates in the liberation of resources including amino acids and energy to maintain homoeostasis. Autophagy is particularly important in stress conditions such as nutrient starvation and any perturbation in the ability of the cell to activate or regulate autophagy can lead to cellular dysfunction and disease. An area of intense research interest is the role and indeed the fate of autophagy during cellular and organismal ageing. Age-related disorders are associated with increased cellular stress and assault including DNA damage, reduced energy availability, protein aggregation and accumulation of damaged organelles. A reduction in autophagy activity has been observed in a number of ageing models and its up-regulation via pharmacological and genetic methods can alleviate age-related pathologies. In particular, autophagy induction can enhance clearance of toxic intracellular waste associated with neurodegenerative diseases and has been comprehensively demonstrated to improve lifespan in yeast, worms, flies, rodents and primates. The situation, however, has been complicated by the identification that autophagy up-regulation can also occur during ageing. Indeed, in certain situations, reduced autophagosome induction may actually provide benefits to ageing cells. Future studies will undoubtedly improve our understanding of exactly how the multiple signals that are integrated to control appropriate autophagy activity change during ageing, what affect this has on autophagy and to what extent autophagy contributes to age-associated pathologies. Identification of mechanisms that influence a healthy lifespan is of economic, medical and social importance in our ‘ageing’ world.

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