Uptake of horseradish peroxidase in sensory nerve terminals of mouse trigeminal nerve

1979 ◽  
Vol 46 (3) ◽  
pp. 191-196 ◽  
Author(s):  
L. A. Persson ◽  
K. Kristensson
Keyword(s):  
Horseradish Peroxidase ◽  
Trigeminal Nerve ◽  
Sensory Nerve ◽  
Nerve Terminals

Development of an experimental model to study trigeminal nerve-mediated vasodilation on the human forehead

Cephalalgia ◽  
2014 ◽  
Vol 34 (7) ◽  
pp. 514-522 ◽  
Author(s):  
K Ibrahimi ◽  
S Vermeersch ◽  
AHJ Danser ◽  
CM Villalón ◽  
AH van den Meiracker ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Trigeminal Nerve ◽  
Transient Receptor Potential ◽  
Sensory Nerve ◽  
Receptor Potential ◽  
Doppler Imaging ◽  
Transient Receptor Potential Vanilloid ◽  
Nerve Terminals ◽  
Capsaicin Application ◽  
Transient Receptor

Background During migraine, trigeminal sensory nerve terminals release calcitonin gene-related peptide (CGRP), inducing nociception and vasodilation. Applied on the skin, capsaicin activates the transient receptor potential vanilloid type 1 (TRPV1) channel and releases CGRP from sensory nerve terminals, thus increasing dermal blood flow (DBF). Using capsaicin application and electrical stimulation of the forehead skin, a trigeminal nerve-innervated dermatome, we aimed to develop a model to measure trigeminal nerve-mediated vasodilation in humans. Methods Using laser Doppler imaging, forehead DBF responses to application of capsaicin (0.06 mg/ml and 6.0 mg/ml) and saline, with and without iontophoresis, were studied in healthy subjects. The within-subject coefficient of variation (WCV) of repeated DBF measurements was calculated to assess reproducibility. Results Maximal DBF responses to 6.0 mg/ml capsaicin with and without iontophoresis did not differ (Emax 459 ± 32 and 424 ± 32 arbitrary units (a.u.), WCV 6 ± 4%). In contrast, DBF responses to 0.06 mg/ml capsaicin were significantly larger with than without iontophoresis (Emax 307 ± 60 versus 187 ± 21 a.u., WCV 21 ± 13%). Saline with iontophoresis significantly increased DBF (Emax: 245 ± 26 a.u, WCV 11 ± 8%), while saline application without iontophoresis did not affect DBF. Conclusion Topical application of capsaicin and electrical stimulation induce reproducible forehead DBF increases and therefore are suitable to study trigeminal nerve-mediated vasodilation in humans.

Regulation of neuropeptide release

1980 ◽  
Vol 210 (1178) ◽  
pp. 91-111 ◽  
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Gaba Receptors ◽  
Opiate Receptors ◽  
Sensory Nerve ◽  
Substantia Gelatinosa ◽  
Nerve Terminals ◽  
Analgesic Effects ◽  
Spinal Cord Level

The demonstration of depolarization-induced release of substance P, Met- and Leu-enkephalin, somatostatin, neurotensin, vasoactive intestinal polypeptide and cholecystokinin-like material from various regions of rat brain in vitro supports the hypothesis that these and other neuropeptides may act as neurotransmitters. In each case the stimulusevoked release, but not the basal release, of peptide was dependent on the presence of calcium ions in the external medium. The stimulus-evoked release of substance P from nerve terminals in rat substantia nigra may be regulated by presynaptic γ -aminobutyric acid (GABA) receptors. The possible existence of presynaptic opiate receptors on substance P-containing sensory nerve terminals may offer an explanation for the analgesic effects of opiates at spinal cord level, and for the existence of enkephalin neurons in substantia gelatinosa. Capsaicin releases substance P from spinal cord nerve terminals and may impair their function, while having no effect on substance P neurons in supraspinal regions. The possibility of cosecretion of peptide and amine products from the same cells is discussed.

The sensory nerve terminals of the mesentery

1973 ◽  
Vol 85 (4) ◽  
pp. 514-532
Author(s):  
J. Vajda ◽  
Elisabeth Fehér ◽  
K. Csányi
Keyword(s):  
Sensory Nerve ◽  
Nerve Terminals

scholarly journals The Effects of Polarizing Current on Nerve Terminal Impulses Recorded from Polymodal and Cold Receptors in the Guinea-pig Cornea

2002 ◽  
Vol 120 (3) ◽  
pp. 395-405 ◽  
Author(s):  
Richard W. Carr ◽  
Svetlana Pianova ◽  
James A. Brock
Keyword(s):  
Guinea Pig ◽  
Nerve Terminal ◽  
Sensory Nerve ◽  
Outward Current ◽  
Nerve Terminals ◽  
Functional Difference ◽  
Inward Current ◽  
Cold Receptor ◽  
Cold Receptors

It was reported recently that action potentials actively invade the sensory nerve terminals of corneal polymodal receptors, whereas corneal cold receptor nerve terminals are passively invaded (Brock, J.A., S. Pianova, and C. Belmonte. 2001. J. Physiol. 533:493–501). The present study investigated whether this functional difference between these two types of receptor was due to an absence of voltage-activated Na+ conductances in cold receptor nerve terminals. To address this question, the study examined the effects of polarizing current on the configuration of nerve terminal impulses recorded extracellularly from single polymodal and cold receptors in guinea-pig cornea isolated in vitro. Polarizing currents were applied through the recording electrode. In both receptor types, hyperpolarizing current (+ve) increased the negative amplitude of nerve terminal impulses. In contrast, depolarizing current (−ve) was without effect on polymodal receptor nerve terminal impulses but increased the positive amplitude of cold receptor nerve terminal impulses. The hyperpolarization-induced increase in the negative amplitude of nerve terminal impulses represents a net increase in inward current. In both types of receptor, this increase in inward current was reduced by local application of low Na+ solution and blocked by lidocaine (10 mM). In addition, tetrodotoxin (1 μM) slowed but did not reduce the hyperpolarization-induced increase in the negative amplitude of polymodal and cold nerve terminal impulses. The depolarization-induced increase in the positive amplitude of cold receptor nerve terminal impulses represents a net increase in outward current. This change was reduced both by lidocaine (10 mM) and the combined application of tetraethylammomium (20 mM) and 4-aminopyridine (1 mM). The interpretation is that both polymodal and cold receptor nerve terminals possess high densities of tetrodotoxin-resistant Na+ channels. This finding suggests that in cold receptors, under normal conditions, the Na+ conductances are rendered inactive because the nerve terminal region is relatively depolarized.

Sensory Nerve Conduction and Somatosensory Evoked Potentials of the Trigeminal Nerve in Horses with Idiopathic Headshaking

2013 ◽  
Vol 27 (6) ◽  
pp. 1571-1580 ◽  
Author(s):  
M. Aleman ◽  
D.C. Williams ◽  
R.J. Brosnan ◽  
J.E. Nieto ◽  
K.J. Pickles ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Trigeminal Nerve ◽  
Somatosensory Evoked Potentials ◽  
Nerve Conduction ◽  
Sensory Nerve
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