Expression of viral antigens in the central nervous system of visna-infected sheep: an immunohistochemical study on experimentsl visna induced by virus strains of increased neurovirulence

1989 ◽  
Vol 77 (3) ◽  
pp. 299-306 ◽  
Author(s):  
G. Georgsson ◽  
D. J. Houwers ◽  
P. A. P�lsson ◽  
G. P�tursson
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immunohistochemical Study ◽  
Infected Sheep ◽  
Viral Antigens ◽  
The Central Nervous System ◽  
Virus Strains

Immunohistochemical study on the distribution of homocysteine in the central nervous system of transgenic mice expressing a human Cu/Zn SOD mutation

2003 ◽  
Vol 967 (1-2) ◽  
pp. 226-234 ◽  
Author(s):  
Yoon Hee Chung ◽  
Jin-Joo Hong ◽  
Chung Min Shin ◽  
Kyeung Min Joo ◽  
Myeung Ju Kim ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transgenic Mice ◽  
Immunohistochemical Study ◽  
The Central Nervous System

Bombesin-like immunoreactivity in the central nervous system of capsaicin-treated rats: a radioimmunoassay and immunohistochemical study

1985 ◽  
Vol 342 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Michael W. Decker ◽  
Andrew C. Towle ◽  
Garth Bissette ◽  
Robert A. Mueller ◽  
Jean M. Lauder ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immunohistochemical Study ◽  
The Central Nervous System

EXPERIMENTAL CEREBROSPINAL NEMATODIASIS (PNEUMOSTRONGYLUS TENUIS) IN SHEEP

1966 ◽  
Vol 44 (5) ◽  
pp. 889-894 ◽  
Author(s):  
Roy C. Anderson ◽  
Uta R. Strelive
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Infected Sheep ◽  
Natural Resistance ◽  
Infective Larvae ◽  
Normal Host ◽  
The Central Nervous System ◽  
Resistance To Infection

Six lambs were each infected experimentally with 50–1000 infective larvae of Pneumostrongylus tenuis. Three animals displayed neurologic signs. Lesions and dead or living worms were found in the central nervous system of all infected lambs. It is concluded, however, that sheep have a good natural resistance to infection and that P. tenuis will not mature in them. Before P. tenuis is diagnosed in naturally infected sheep it would be advisable to establish whether the sheep have been in contact with white-tailed deer, the normal host.

Rift Valley Fever Virus-induced Encephalomyelitis and Hepatitis in Calves

1992 ◽  
Vol 29 (6) ◽  
pp. 495-502 ◽  
Author(s):  
M. K. Rippy ◽  
M. J. Topper ◽  
C. A. Mebus ◽  
J. C. Morrill
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Positive Staining ◽  
Post Inoculation ◽  
Valley Fever ◽  
Viral Antigens ◽  
The Central Nervous System ◽  
The Brain

Three calves (Nos. 1, 2 = 7 days old; No. 3 = 21 days old) were inoculated subcutaneously with virulent Rift Valley fever (RVF) virus. All calves became viremic and clinically ill, but the two 7-day-old calves were moribund and were euthanatized subsequently on post-inoculation day (PID) 3. Highest viral titers were measured in the serum, with lesser concentrations in the brain, heart, spleen, and liver of these animals. Viral antigens were detected by immunohistochemical analysis only in the livers, where positive staining was localized in coalescing foci of hepatocellular necrosis. The 21-day-old calf appeared to recover after viremia and pyrexia but became lethargic and ataxic and was euthanatized on PID 9. The calf was no longer viremic, and RVF virus was isolated only from the brain. Microscopic examination of the central nervous system revealed diffuse perivascular infiltrates of lymphocytes and macrophages, multifocal meningitis, and focal areas of neuronal necrosis and aggregates of macrophages, lymphocytes, and neutrophils throughout all regions of the brain and cervical spinal cord. There was positive immunohistochemical staining for viral antigens within the cytoplasm of neurons and glial cells throughout the central nervous system. Thus, RVF virus can cause encephalomyelitis in calves, and the specific virologic diagnosis can be made by immunohistochemical localization of viral antigens in formalin-fixed tissues.

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