Moclobemide, a new reversible MAO inhibitor ? interaction with tyramine and tricyclic antidepressants in healthy volunteers and depressive patients

1986 ◽  
Vol 88 (2) ◽  
pp. 153-157 ◽  
Author(s):  
A. Korn ◽  
H. G. Eichler ◽  
R. Fischbach ◽  
S. Gasic
Keyword(s):  
Healthy Volunteers ◽  
Tricyclic Antidepressants ◽  
Mao Inhibitor ◽  
Depressive Patients ◽  
Inhibitor Interaction

What is the nonverbal communication of depression? Assessing expressive differences between depressive patients and healthy volunteers during clinical interviews

2018 ◽  
Vol 238 ◽  
pp. 636-644 ◽  
Author(s):  
Juliana Teixeira Fiquer ◽  
Ricardo Alberto Moreno ◽  
Andre R. Brunoni ◽  
Vivian Boschesi Barros ◽  
Fernando Fernandes ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Nonverbal Communication ◽  
Clinical Interviews ◽  
Depressive Patients

Dopamine agonists treatment of chronic depressive patients resistant to tricyclic antidepressants

1998 ◽  
Vol 8 ◽  
pp. S177
Author(s):  
S. Mosolov ◽  
E. Tsukarzi ◽  
E. Missionznik ◽  
A. Sharov ◽  
M. Uzbekov
Keyword(s):  
Dopamine Agonists ◽  
Tricyclic Antidepressants ◽  
Depressive Patients

Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect

2009 ◽  
Vol 40 (9) ◽  
pp. 1443-1451 ◽  
Author(s):  
J. Horacek ◽  
M. Brunovsky ◽  
T. Novak ◽  
B. Tislerova ◽  
T. Palenicek ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Acute Effect ◽  
Antidepressant Effect ◽  
Blood Levels ◽  
Quantitative Electroencephalography ◽  
Double Blind ◽  
Competitive Antagonist ◽  
Ketamine Infusion ◽  
Fast Acting ◽  
Depressive Patients

BackgroundTheta cordance is a novel quantitative electroencephalography (QEEG) measure that correlates with cerebral perfusion. A series of clinical studies has demonstrated that the prefrontal theta cordance value decreases after 1 week of treatment in responders to antidepressants and that this effect precedes clinical improvement. Ketamine, a non-competitive antagonist of N-methyl-d-aspartate (NMDA) receptors, has a unique rapid antidepressant effect but its influence on theta cordance is unknown.MethodIn a double-blind, cross-over, placebo-controlled experiment we studied the acute effect of ketamine (0.54 mg/kg within 30 min) on theta cordance in a group of 20 healthy volunteers.ResultsKetamine infusion induced a decrease in prefrontal theta cordance and an increase in the central region theta cordance after 10 and 30 min. The change in prefrontal theta cordance correlated with ketamine and norketamine blood levels after 10 min of ketamine infusion.ConclusionsOur data indicate that ketamine infusion immediately induces changes similar to those that monoamineric-based antidepressants induce gradually. The reduction in theta cordance could be a marker and a predictor of the fast-acting antidepressant effect of ketamine, a hypothesis that could be tested in depressive patients treated with ketamine.

Use of dopaminergic agonist in treatment of chronic depressive patients resistant to tricyclic antidepressants

1996 ◽  
Vol 6 ◽  
pp. S4-90-S4-91
Author(s):  
E. Tsucarzi ◽  
S. Mosolov ◽  
E. Missionznik ◽  
A. Sharov ◽  
M. Uzbekov
Keyword(s):  
Tricyclic Antidepressants ◽  
Dopaminergic Agonist ◽  
Depressive Patients

Effects of tianeptine on attention, memory and psychomotor performances using neuropsychological methods in young healthy volunteers

1993 ◽  
Vol 8 (S2) ◽  
pp. 95s-102s
Author(s):  
MF Poirier ◽  
A Galinowski ◽  
I Amado-Boccara ◽  
B Delalleau ◽  
N Gougoulis ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Learning Effect ◽  
Tricyclic Antidepressants ◽  
Large Range ◽  
Inductive Reasoning ◽  
Antidepressant Drug ◽  
Double Blind ◽  
Level Of Functioning ◽  
Reasoning Test ◽  
Neuropsychological Methods

SummaryA study was performed in young healthy volunteers in order to test the possible action of tianeptine, a new antidepressant drug, on cognitive performances. Attention tests, memory tests, a non-verbal inductive reasoning test and a sleep questionnaire were used in this double-blind placebo-controlled crossover study. The two one-week drug administration periods were separated by a one-week wash-out period. The methodology permitted us to evaluate the learning effect during the familiarization with the tests and to clear the results of the study from this parameter which could possibly distort analysis. For this large range of tests, the results showed that tianeptine did not affect the level of functioning of the volunteers after their familiarization with the tests. These results are in contrast with those obtained by different authors with classical tricyclic antidepressants.

The Peripheral Anticholinergic Activity of Tricyclic Antidepressants: Comparison of Amitriptyline and Desipramine in Human Volunteers

1980 ◽  
Vol 137 (5) ◽  
pp. 433-439 ◽  
Author(s):  
E. Szabadi ◽  
P. Gaszner ◽  
C. M. Bradshaw
Keyword(s):  
Heart Rate ◽  
Healthy Volunteers ◽  
Pupil Size ◽  
Tricyclic Antidepressants ◽  
Pupil Diameter ◽  
Reliable Measure ◽  
Anticholinergic Activity ◽  
Adrenergic Mechanisms ◽  
Human Volunteers ◽  
Oral Doses

SummaryThe effects of three single oral doses (25 mg, 50 mg and 100 mg) of amitriptyline and desipramine, and of placebo, were compared on a range of cholinergic functions (resting pupil diameter, pilocarpine-evoked miosis, baseline-sweating, carbachol-evoked sweating, salivation, heart rate) in eight healthy volunteers. Three measures (pilocarpine-evoked miosis, carbachol-evoked sweating and salivation) reflected the antimuscarinic property of the antidepressants; in two tests (pilocarpine-evoked miosis and salivation) amitriptyline appeared to be more potent than desipramine. Resting pupil diameter was not affected by amitriptyline, whereas desipramine caused mydriasis, indicating that pupil size is not a reliable measure of anticholinergic activity in the case of drugs which also affect adrenergic mechanisms. Baseline-sweating and heart rate were not affected by the antidepressants.

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