Cardiocirculatory effects of moclobemide (Ro 11-1163), a new reversible, a short-acting MAO-inhibitor with preferential Type A inhibition, in healthy volunteers and depressive patients

1983 ◽  
Vol 25 (2) ◽  
pp. 173-177 ◽  
Author(s):  
S. Gasic ◽  
A. Korn ◽  
H. G. Eichler ◽  
I. Oberhummer ◽  
H. G. Zapotoczky
Keyword(s):  
Healthy Volunteers ◽  
Type A ◽  
Mao Inhibitor ◽  
Short Acting ◽  
Cardiocirculatory Effects ◽  
Depressive Patients

Characterization of a New, Short-Acting and Specific Inhibitor of Type A Monoamine Oxidase

2015 ◽  
pp. 31-52 ◽  
Author(s):  
P. C. Waldmeier ◽  
P. A. Baumann ◽  
A. Delini-Stula ◽  
R. Bernasconi ◽  
K. Sigg ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Specific Inhibitor ◽  
Type A ◽  
Short Acting

What is the nonverbal communication of depression? Assessing expressive differences between depressive patients and healthy volunteers during clinical interviews

2018 ◽  
Vol 238 ◽  
pp. 636-644 ◽  
Author(s):  
Juliana Teixeira Fiquer ◽  
Ricardo Alberto Moreno ◽  
Andre R. Brunoni ◽  
Vivian Boschesi Barros ◽  
Fernando Fernandes ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Nonverbal Communication ◽  
Clinical Interviews ◽  
Depressive Patients

Plasma protein binding of the reversible type a MAO inhibitor cimoxatone (MD 780515)

1983 ◽  
Vol 32 (15) ◽  
pp. 2303-2308 ◽  
Author(s):  
V. Rovei ◽  
F. Chanoine ◽  
M.Strolin Benedetti ◽  
R. Zini ◽  
J.P. Tillement
Keyword(s):  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Type A ◽  
Mao Inhibitor

Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: implications for antidepressant effect

2009 ◽  
Vol 40 (9) ◽  
pp. 1443-1451 ◽  
Author(s):  
J. Horacek ◽  
M. Brunovsky ◽  
T. Novak ◽  
B. Tislerova ◽  
T. Palenicek ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Acute Effect ◽  
Antidepressant Effect ◽  
Blood Levels ◽  
Quantitative Electroencephalography ◽  
Double Blind ◽  
Competitive Antagonist ◽  
Ketamine Infusion ◽  
Fast Acting ◽  
Depressive Patients

BackgroundTheta cordance is a novel quantitative electroencephalography (QEEG) measure that correlates with cerebral perfusion. A series of clinical studies has demonstrated that the prefrontal theta cordance value decreases after 1 week of treatment in responders to antidepressants and that this effect precedes clinical improvement. Ketamine, a non-competitive antagonist of N-methyl-d-aspartate (NMDA) receptors, has a unique rapid antidepressant effect but its influence on theta cordance is unknown.MethodIn a double-blind, cross-over, placebo-controlled experiment we studied the acute effect of ketamine (0.54 mg/kg within 30 min) on theta cordance in a group of 20 healthy volunteers.ResultsKetamine infusion induced a decrease in prefrontal theta cordance and an increase in the central region theta cordance after 10 and 30 min. The change in prefrontal theta cordance correlated with ketamine and norketamine blood levels after 10 min of ketamine infusion.ConclusionsOur data indicate that ketamine infusion immediately induces changes similar to those that monoamineric-based antidepressants induce gradually. The reduction in theta cordance could be a marker and a predictor of the fast-acting antidepressant effect of ketamine, a hypothesis that could be tested in depressive patients treated with ketamine.

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