Urinary acid excretion in aged subjects

1992 ◽  
Vol 1 (3) ◽  
pp. 157-162
Author(s):  
Otto Sch�ck ◽  
Hana N�dvorn�kov� ◽  
Vladim�r Teplan
Keyword(s):  
Acid Excretion ◽  
Aged Subjects ◽  
Urinary Acid

scholarly journals 48 Urinary Acid Excretion in the Intact Lamb Fetus

1967 ◽  
Vol 1 (3) ◽  
pp. 212-212
Author(s):  
Fred G Smith ◽  
Richard Bashore
Keyword(s):  
Acid Excretion ◽  
Urinary Acid

A4982 Effects of obesity on urinary acid excretion and kidney injury in chronic kidney disease

2018 ◽  
Vol 36 ◽  
pp. e40
Author(s):  
Yuichiro Izumi ◽  
Koji Eguchi ◽  
Yushi Nakayama ◽  
Naomi Matsuo ◽  
Akiko Hara ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Injury ◽  
Acid Excretion ◽  
Urinary Acid

Effects of Chloride Restriction and Depletion on Acid-Base Balance and Chloride Conservation in the Rat

1970 ◽  
Vol 38 (3) ◽  
pp. 385-396 ◽  
Author(s):  
R. G. Luke ◽  
Y. Warren ◽  
M. Kashgarian ◽  
H. Levitin
Keyword(s):  
Proximal Tubule ◽  
Respiratory Acidosis ◽  
Dietary Sodium ◽  
Acid Excretion ◽  
Acid Base Balance ◽  
Plasma Bicarbonate ◽  
Chloride Depletion ◽  
Plasma Chloride ◽  
Urinary Acid ◽  
Net Acid Excretion

1. In the rat dietary chloride restriction has been shown to cause an elevation of the plasma bicarbonate and urinary net acid excretion, provided dietary sodium is available. Likewise the degree of elevation of plasma bicarbonate during chloride depletion, produced by prior exposure to 8% CO2 for 24 hr, was dependent on whether sodium (as the neutral phosphate) was or was not being ingested. 2. Correction of the hypochloraemia and the elevated plasma bicarbonate following exposure to CO2 and subsequent recovery on a low chloride diet is more complete in the rat than the dog. Evidence is presented that the plasma chloride rises in the rat because of the movement of chloride out of intracellular sites, and that chloride depletion and/or the associated metabolic alkalosis elevates endogenous acid production. 3. Chloride depleted rats were re-exposed to 8% CO2 in air. Renal chloride conservation remained intact. The hypochloraemia and rise in plasma bicarbonate in response to CO2 were not dependent on chloruresis although urinary acid excretion and the rise in serum bicarbonate were inhibited when the plasma chloride did not fall. 4. Consideration of these experiments with the related micropuncture experiments of Warren et al. (1970) suggests that: (a) the intimate relationship between hypochloraemia and the elevation of plasma bicarbonate in respiratory acidosis is related to reciprocal changes in proximal tubular absorption of chloride and bicarbonate; (b) chloride depletion can increase bicarbonate absorption in the proximal tubule and urinary net acid excretion; (c) a rise in TF/P Cl in the proximal tubule does not necessarily correlate with changes in external chloride balance; (d) the distal chloride conserving mechanism is unaffected by rates of sodium or phosphate excretion, exposure to carbon dioxide, or increases in the rate of tubular bicarbonate absorption.

scholarly journals Endogenous Endothelins Mediate Increased Acidification in Remnant Kidneys

2001 ◽  
Vol 12 (9) ◽  
pp. 1826-1835
Author(s):  
DONALD E. WESSON
Keyword(s):  
Base Excess ◽  
Left Kidney ◽  
Acid Excretion ◽  
Dietary Acid ◽  
Distal Tubules ◽  
Excretion Rates ◽  
Urinary Acid ◽  
And Control ◽  
Net Acid Excretion

Abstract. Because endothelins (ET) mediate increased renal acidification induced by dietary acid and animals with reduced renal mass exhibit increased urinary ET-1 excretion, the hypothesis that ET mediate increased renal acidification in remnant kidneys was tested. Four weeks before the study, rats underwent a 5/6 nephrectomy (Nx) and a microdialysis apparatus was inserted into the remnant left kidney and the left kidney of sham-treated control animals, for measurements of renal ET-1 contents. Nx animals exhibited greater ET-1 addition to the renal dialysate than did control animals (681 ± 91 versus 290 ± 39 fmol/g kidney wt per min, P < 0.002) and greater urinary ET-1 excretion (346 ± 79 versus 125 ± 24 fmol/d, P < 0.02). Urinary net acid excretion rates were similar for Nx and control animals (732 ± 106 versus 1005 ± 293 μEq/d, P = 0.4), but Nx animals exhibited greater in situ HCO3- reabsorption in proximal (972.3 ± 77 versus 482.6 ± 42.4 pmol/min, P < 0.001) and distal (62.7 ± 6.7 versus 24.3 ± 2.5 pmol/min, P < 0.001) tubules. Orally administered bosentan, an ETA/B receptor antagonist, decreased urinary net acid excretion in Nx animals (to 394 ± 99 μEq/d, P < 0.04 versus without bosentan); the decrease was mediated by decreased HCO3- reabsorption in both the proximal and distal tubules. Furthermore, bosentan decreased blood base excess in Nx animals (0.1 ± 0.3 to -0.12 ± 0.03 μM/ml blood, P < 0.002), consistent with acid retention. The data demonstrate that endogenous ET mediate increased urinary acid excretion in the remnant kidneys of Nx animals.

Insufficiency of urinary acid excretion of overweight or obese patients with chronic kidney disease and its involvement with renal tubular injury

Nephrology ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 1131-1141
Author(s):  
Koji Eguchi ◽  
Yuichiro Izumi ◽  
Yushi Nakayama ◽  
Hideki Inoue ◽  
Takahiro Marume ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Obese Patients ◽  
Acid Excretion ◽  
Tubular Injury ◽  
Renal Tubular ◽  
Urinary Acid

scholarly journals Urinary acid excretion can predict changes in bone metabolism during space flight

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Sara R. Zwart ◽  
Martina Heer ◽  
Scott M. Smith
Keyword(s):  
Bone Metabolism ◽  
Space Flight ◽  
Acid Excretion ◽  
Urinary Acid

Renal Excretion of Bicarbonate and Hydrogen Ions: Effects of Mannitol Diuresis in Normal Man

1972 ◽  
Vol 43 (4) ◽  
pp. 561-567 ◽  
Author(s):  
P. A. Poole-Wilson ◽  
J. Patrick ◽  
G. A. MacGregor ◽  
N. F. Jones
Keyword(s):  
Renal Excretion ◽  
Hydrogen Ion ◽  
Normal Adult ◽  
Hydrogen Ions ◽  
Acid Excretion ◽  
Urinary Ph ◽  
Titratable Acid ◽  
Initial Ph ◽  
Normal Man ◽  
Urinary Acid

1. The pattern of urinary acid excretion during mannitol diuresis was studied in five normal adult subjects. 2. At peak diuresis (osmolal clearance 19·3–27·9 ml/min), the urinary pH approached 6·9 irrespective of the initial pH. 3. Total hydrogen ion excretion fell sharply during mannitol diuresis. Changes in the excretion of ammonium and titratable acid were small and variable, but in each subject bicarbonate excretion increased markedly. 4. Despite previous conflicting published results urinary acid excretion during mannitol diuresis in man resembles that in the dog and is dominated by a bicarbonate diuresis.

Urine stones of different chemical composition occurrence depending on the level of uricuria

2020 ◽  
Vol 10 (2) ◽  
pp. 107-113
Author(s):  
Michail Y. Prosiannikov ◽  
Nikolay V Anokhin ◽  
Sergey A. Golovanov ◽  
Olga V Konstantinova ◽  
Andrey V. Sivkov ◽  
...  
Keyword(s):  
Uric Acid ◽  
Chemical Composition ◽  
Calcium Oxalate ◽  
Biochemical Analysis ◽  
Urinary Stone ◽  
Urinary Stones ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Calcium Oxalate Stones ◽  
Urinary Acid

Introduction. According to modern concepts one of the key links in the pathogenesis of urolithiasis is metabolic lithogenic disturbances. The study of the complex effect of many factors on the metabolism of urolithiasis patient is the basis of modern scientific research. We studied the frequency of various chemical urinary stones occurrence depending on various levels of uricuria. Materials and methods. Data from of 708 urolithiasis patients (303 men and 405 women) were analized. The results of blood and urine biochemical analysis and chemical composition of urinary stone were studied. The degree of uricuria was ranked by 10 intervals: from 0.4 to 14.8 mmol/day to assess the occurrence of different stones at various levels of uricuria. Results. The incidence of calculi consisting of uric acid also increases with increasing levels of uric acid in the urine. An increase in the level of uricuria above 3.11 mmol/day is observed to increase calcium-oxalate stones occurrence. Decrease in the prevalence of carbonatapatite and struvite stones observed at an increase of urine uric acid excretion. At high levels of uric acid excretion, we found uric acid and calcium oxalate stones most often. Conclusion. Control over the level of urinary acid excretion in urine is important in case of calcium-oxalate and uric acid urolithiasis.

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