Insufficiency of urinary acid excretion of overweight or obese patients with chronic kidney disease and its involvement with renal tubular injury

Nephrology ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 1131-1141
Author(s):  
Koji Eguchi ◽  
Yuichiro Izumi ◽  
Yushi Nakayama ◽  
Hideki Inoue ◽  
Takahiro Marume ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Obese Patients ◽  
Acid Excretion ◽  
Tubular Injury ◽  
Renal Tubular ◽  
Urinary Acid

A4982 Effects of obesity on urinary acid excretion and kidney injury in chronic kidney disease

2018 ◽  
Vol 36 ◽  
pp. e40
Author(s):  
Yuichiro Izumi ◽  
Koji Eguchi ◽  
Yushi Nakayama ◽  
Naomi Matsuo ◽  
Akiko Hara ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Injury ◽  
Acid Excretion ◽  
Urinary Acid

The association of renal tubular inflammatory and injury markers with uric acid excretion in chronic kidney disease patients

2020 ◽  
Vol 52 (5) ◽  
pp. 923-932 ◽  
Author(s):  
Yuqi Zheng ◽  
Haochen Guan ◽  
Xun Zhou ◽  
Ying Xu ◽  
Chensheng Fu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Acid Excretion ◽  
Uric Acid Excretion ◽  
Renal Tubular

scholarly journals Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease

2021 ◽  
Vol 12 (5) ◽  
Author(s):  
Bohan Chen ◽  
Pei Wang ◽  
Xianhui Liang ◽  
Chunming Jiang ◽  
Yan Ge ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Fibrosis ◽  
Binding Protein ◽  
Renal Tubules ◽  
Genetic Ablation ◽  
Renal Tubular Cells ◽  
Renal Tubular ◽  
Renal Fibrogenesis ◽  
Tgf Β1

AbstractRenal tubular epithelial cells (TECs) play a key role in renal fibrogenesis. After persistent injuries that are beyond self-healing capacity, TECs will dedifferentiate, undergo growth arrest, convert to profibrogenic phenotypes, and resort to maladaptive plasticity that ultimately results in renal fibrosis. Evidence suggests that glycogen synthase kinase (GSK) 3β is centrally implicated in kidney injury. However, its role in renal fibrogenesis is obscure. Analysis of publicly available kidney transcriptome database demonstrated that patients with progressive chronic kidney disease (CKD) exhibited GSK3β overexpression in renal tubulointerstitium, in which the predefined hallmark gene sets implicated in fibrogenesis were remarkably enriched. In vitro, TGF-β1 treatment augmented GSK3β expression in TECs, concomitant with dedifferentiation, cell cycle arrest at G2/M phase, excessive accumulation of extracellular matrix, and overproduction of profibrotic cytokines like PAI-1 and CTGF. All these profibrogenic phenotypes were largely abrogated by GSK3β inhibitors or by ectopic expression of a dominant-negative mutant of GSK3β but reinforced in cells expressing the constitutively active mutant of GSK3β. Mechanistically, GSK3β suppressed, whereas inhibiting GSK3β facilitated, the activity of cAMP response element-binding protein (CREB), which competes for CREB-binding protein, a transcriptional coactivator essential for TGF-β1/Smad signaling pathway to drive TECs profibrogenic plasticity. In vivo, in mice with folic acid-induced progressive CKD, targeting of GSK3β in renal tubules via genetic ablation or by microdose lithium mitigated the profibrogenic plasticity of TEC, concomitant with attenuated interstitial fibrosis and tubular atrophy. Collectively, GSK3β is likely a pragmatic therapeutic target for averting profibrogenic plasticity of TECs and improving renal fibrosis.

scholarly journals Obesity indices and adipokines in non-diabetic obese patients with early stages of chronic kidney disease

2013 ◽  
Vol 19 ◽  
pp. 1063-1072 ◽  
Author(s):  
Mariusz Stępień ◽  
Anna Stępień ◽  
Rafał Nikodem Wlazeł ◽  
Marek Paradowski ◽  
Maciej Banach ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Obese Patients ◽  
Early Stages ◽  
Obesity Indices

Effects of bariatric surgery on the glomerular integrity of morbidly obese patients with chronic kidney disease (CKD)

2018 ◽  
Vol 14 (11) ◽  
pp. S2 ◽  
Author(s):  
David Romero Funes ◽  
David Gutierrez Blanco ◽  
Mauricio F Sarmiento-Cobos ◽  
Rama Ganga ◽  
Emanuele Lo Menzo ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Morbidly Obese ◽  
Obese Patients
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