Structural features of biologically active coordination compounds of vanillinsemicarbazone

1985 ◽  
Vol 10 (3) ◽  
pp. 94-96 ◽  
Author(s):  
Kuntebommanahalli N. Thimmaiah ◽  
Winston D. Lloyd ◽  
Gujjarahalli T. Chandrappa
Keyword(s):  
Coordination Compounds ◽  
Structural Features ◽  
Biologically Active

On the diagnostics of Adonis L. species (Ranunculaceae) of the Russian flora

2020 ◽  
pp. 3-14
Author(s):  
Aleksandr Luferov
Keyword(s):  
Raw Materials ◽  
Natural Populations ◽  
Structural Features ◽  
Biologically Active ◽  
Scientific Medicine ◽  
Diagnostic Features ◽  
Plant Raw Materials ◽  
Similar Chemical ◽  
Chemical Studies ◽  
Alternative Sources

The article provides brief information about cardiotonic, sedative, cytostatic, diuretic, and antibacterial effects of biologically active compounds of Adonis L. (Ranunculaceae) species. Chemical studies allowed to identify the cardiac glycosides, or cardenolides: or cardenolides: adontoxin, adonitol, adonitoxigenin, acetyldigitoxin and others. In scientific medicine, it is currently allowed to use Adonis vernalis L. Other types of Adonis have a similar chemical composition and are offered as substitutes for this official species, for example, Adonis apennina L. Many Adonis species have limited natural resources, and in some regions are rare, requiring conservation of their natural populations. The search for alternative sources of medicinal plant raw materials, based on this, is relevant. The experimental part of our research was carried out using the morphological and geographical method with the involvement of information on ecology and phenology. For the first time summarizes the diagnostic features of Adonis flora of Russian flora. Previously unknown structural features (shape and size of anthers) were identified that characterize the subgenera Adonanthe and Adonis. Taxonomic study of the genus Adonis of the Russian flora allowed us to determine its species composition, clarify its systematic affiliation, and nomenclature synonyms. 9 species were identified. Of these, 6 are perennials belonging to the subgenus Adonanthe, section Consiligo, which includes 2 subsections: Amurenses (2 species) and Vernales, which is differentiated into 2 rows: Apenninae (2 species) and Vernales (2 species). Subgenus Adonis is represented by 2 sections: Adonis (1 species) and Lophocarpa with sections Aestivales (1 species) and Dentatae (1 species). For all the considered species and varieties, the main distribution areas are given. A key has been compiled to determine the wild Adonis species distributed in Russia.

ASSESSMENT OF TOXICITY OF GERMANIUM COORDINATION COMPOUNDS

2019 ◽  
pp. 16-21
Author(s):  
A. V. Kadomtsevа ◽  
I. V. Zhdanovich ◽  
M. S. Piskunovа ◽  
A. N. Lineva ◽  
A. N. Novikova ◽  
...  
Keyword(s):  
Coordination Compounds ◽  
Organometallic Compounds ◽  
Biologically Active ◽  
Pharmacological Properties ◽  
Toxicological Studies ◽  
Methods Of Synthesis ◽  
Promising Area

The synthesis of biologically active coordination compounds and the design on their basis of effective pharmacological preparations is currently the promising area. This paper presents the results of the toxicological studies on digermanium and its complex derivatives. It should be noted that the positive medical properties of organometallic compounds of germanium are confirmed by numerous studies, therefore, the development of the methods of synthesis, as well as investigations of physicochemical and pharmacological properties of these compounds are at the center of attention.

scholarly journals Copper(II) 2,2-Bis(Hydroxymethyl)Propionate Coordination Compounds with Hexamethylenetetramine: From Mononuclear Complex to One-Dimensional Coordination Polymer

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3358
Author(s):  
Sadaf Rauf ◽  
Agata Trzesowska-Kruszynska ◽  
Tomasz Sierański ◽  
Marcin Świątkowski
Keyword(s):  
Coordination Polymer ◽  
Coordination Compounds ◽  
Structural Diversity ◽  
Structural Features ◽  
Mononuclear Complex ◽  
Molar Ratio ◽  
One Dimensional ◽  
1D Coordination Polymer ◽  
Copper Coordination ◽  
Stretching Vibrations

Three new copper coordination compounds derived from 2,2-bis(hydroxymethyl)propionic acid (dmpa) and hexamethylenetetramine (hmta) were obtained and their crystal structures were determined. The stoichiometry of the reagents applied in the syntheses reflects the metal to ligand molar ratio in the formed solid products. Due to the multiple coordination modes of the used ligands, wide structural diversity was achieved among synthesized compounds, i.e., mononuclear [Cu(dmp)2(hmta)2(H2O)] (1), dinuclear [Cu2(dmp)4(hmta)2] (2), and 1D coordination polymer [Cu2(dmp)4(hmta)]n (3). Their supramolecular structures are governed by O—H•••O and O—H•••N hydrogen bonds. The compounds were characterized in terms of absorption (UV-Vis and IR) and thermal properties. The relationships between structural features and properties were discussed in detail. Owing to discrepancies in the coordination mode of a dmp ligand, bidentate chelating in 1, and bidentate bridging in 2 and 3, there is a noticeable change in the position of the bands corresponding to the stretching vibrations of the carboxylate group in the IR spectra. The differences in the structures of the compounds are also reflected in the nature and position of the UV-Vis absorption maxima, which are located at lower wavelengths for 1.

H-Bonded and metal(ii)–organic architectures assembled from an unexplored aromatic tricarboxylic acid: structural variety and functional properties

2020 ◽  
Vol 49 (21) ◽  
pp. 7197-7209 ◽  
Author(s):  
Jin-Zhong Gu ◽  
Shi-Mao Wan ◽  
Marina V. Kirillova ◽  
Alexander M. Kirillov
Keyword(s):  
Nicotinic Acid ◽  
Functional Properties ◽  
Building Block ◽  
Coordination Compounds ◽  
Structural Features ◽  
Tricarboxylic Acid ◽  
Structural Variety

2,5-Di(4-carboxylphenyl)nicotinic acid was explored as a novel building block for assembling nine metal(ii) coordination compounds; these were fully characterized and their structural features and functional properties were investigated.

STRUCTURAL FEATURES, COMPUTATIONAL STUDIES AND BIOLOGICAL ANALYSIS: SCHIFF’S BASE LIGAND AND ITS COORDINATION COMPOUNDS

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (07) ◽  
pp. 22-31
Author(s):  
Seema Gautam ◽  
Sulekh Chandra ◽  
Jugmendra Singh ◽  
Navneet Manav ◽  
Vinod K Paliwal ◽  
...  
Keyword(s):  
Metal Ions ◽  
Coordination Compounds ◽  
Computational Study ◽  
Inhibition Zone ◽  
Antibacterial Activities ◽  
Structural Features ◽  
Schiff’S Base ◽  
H Nmr ◽  
Diffusion Technique ◽  
Elemental Analyses

Structure and biological application based analysis has been carried out for Schiff’s base ligand containing nitrogen and sulphur donor atoms and also for a series of its coordination compounds. Ligand benzil-bis(5-amino-1,3,4-thiadiazole-2-thiol) (L) has been prepared and structural features of ligand investigated by elemental analyses, IR, 1 H-NMR, mass spectra and molecular modeling studies. The chemical reaction of the prepared ligand with metal ions afforded mononuclear coordination compounds of Mn(II) and Co(II) metal ions. The characterization of the coordination compounds is being based on the techniques i.e. elemental analysis, infra-red, UV-visible as well as melting point, molar conductivity and magnetic moment measurement. A computational study has been done to understand the miscellaneous coordination modes of ligand to metal ions. Characterization result shows that coordination compounds exhibit a six coordinated geometrical arrangement i.e. octahedral geometry. The biological inhibition zone (antifungal and antibacterial activities) of synthesized compounds, i.e. ligand and its coordination compounds, has been monitored using well diffusion technique

Search for active candidates in a range of flavonoids regarding SARS-CoV-2 by the method of molecular docking

2021 ◽  
pp. 22-35
Author(s):  
Stanislav V. Pechinskii ◽  
Eduard T. Oganesyan ◽  
Anna G. Kuregyan
Keyword(s):  
Molecular Docking ◽  
Antiviral Activity ◽  
Cost Effective ◽  
Structural Features ◽  
Biologically Active ◽  
Active Structures ◽  
Main Protease ◽  
Targeted Screening ◽  
The Relationship ◽  
Structure And Activity

Molecular docking is a convenient and cost-effective tool for targeted screening of biologically active structures. This method makes it possible to reveal the relationship between structure and activity, as well as to search for new active compounds. Due to the fact that the antiviral activity of flavonoids and their derivatives has been shown experimentally and clinically, the study of their antiviral activity against SARS-CoV-2 is a promising study. In an in silico experiment, the possibility of binding 20 flavonoid ligands and the main protease SARS-CoV-2 was studied. The structural features of flavone and flavanone derivatives have been determined, which determine their ability to block the main protease of the SARS-CoV-2 virus. Structures of eight new candidates that bind the main protease SARS-CoV-2, which have the prospect of synthesis and further pharmacological research, have been proposed.

Efficient Synthesis of Novel N-[4-Methyl-3-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)thiazol-2(3H)-ylidene]benzamide Hybrid Ring System as Potential Antibacterial Agents

2021 ◽  
Vol 17 ◽  
Author(s):  
Hummera Rafique ◽  
Aamer Saeed ◽  
Muhammad Naseem ◽  
Tauqeer Riaz ◽  
Fouzia Perveen ◽  
...  
Keyword(s):  
Bacterial Resistance ◽  
Antioxidant Activities ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Structural Features ◽  
Ring System ◽  
Biologically Active ◽  
Thiazole Ring ◽  
Spectroscopic Techniques ◽  
Hybrid Ring

Background: Heterocyclic compounds display versatile biological applications, so the aim of this paper was to prepare biologically important heterocycles with enhanced bacterial resistance and to evaluate for their various structural features that are responsible for their biological properties. Objective: The objective was to synthesize bacterial resistance compounds with enhanced antibacterial properties. Method: Ester moiety containing thiazole ring was converted into its hydrazide derivatives. These heterocyclic derivatives were cyclized into another ring oxadiazole; hence a hybrid ring system of two biologically active rings was prepared. Result: All the synthesized compounds were characterized by spectroscopic techniques and were screened for their antibacterial potential; they possess significant antibacterial activities. Conclusion: New hybrid heterocyclic ring systems were synthesized by cyclization of hydrazide derivatives by adopting two step strategy in good yields. All the synthesized compounds were evaluated for their antioxidant activities; they showed moderate to significant activities. QSAR and Molecular docking studies were performed to determine the mode of interaction. Experimental and computational data is in accordance with the determined antibacterial activities.

Time-Course Studies of Phytoalexins and Glucosinolates in UV-Irradiated Turnip Tissue

1991 ◽  
Vol 46 (3-4) ◽  
pp. 189-193 ◽  
Author(s):  
Kenji Monde ◽  
Mitsuo Takasugi ◽  
Jenny A. Lewis ◽  
G. Roger Fenwick
Keyword(s):  
High Performance ◽  
Time Course ◽  
Brassica Campestris ◽  
Structural Features ◽  
Biologically Active ◽  
Indole Glucosinolates ◽  
Freeze Dried ◽  
Indole Phytoalexins ◽  
The Individual ◽  
Complex Manner

Sliced turnip root (Brassica campestris L. ssp rapa) was irradiated for a total of 20 min with a 15 W germicidal lamp and the tissue incubated at 25 °C. The effects of such treatment on indole phytoalexins (methoxybrassinin (I); brassinin (II); cyclobrassinin (III); spirobrassinin (IV) and glucosinolates were determined using high performance liquid chromatography procedures. Accumulation of phytoalexins I - III was evident within 8 h of irradiation, whilst formation of spirobrassinin was evident only after 24 h. Maximal levels of III and IV (> 100 μg g-1 freeze dried tissue) were greater than those of I and II (27 and 17 μg g-1, respectively). The individual glucosinolate levels were affected in a complex manner; whilst most glucoinolates decreased on storage, the levels of indole glucosinolates, glucobrassicin (XI) and 1-methoxyglucobrassicin (XIII), increased until 5 to 6 days after irradiation and thereafter declined. Whilst structural features of I - IV , XI and XIII suggest close biosynthetic relationships between these classes of biologically-active indoles, further studies are needed to establish this point unambiguously.

A new series of Co, Ni, Zn, and Cd metal–organic architectures driven by an unsymmetrical biphenyl-tricarboxylic acid: hydrothermal assembly, structural features and properties

2018 ◽  
Vol 47 (22) ◽  
pp. 7431-7444 ◽  
Author(s):  
Jin-Zhong Gu ◽  
Yan Cai ◽  
Zi-Yue Qian ◽  
Min Wen ◽  
Zi-Fa Shi ◽  
...  
Keyword(s):  
Building Block ◽  
Coordination Compounds ◽  
Structural Features ◽  
Tricarboxylic Acid ◽  
Main Building ◽  
Metal Organic

Twelve new Zn(ii), Ni(ii), Co(ii), and Cd(ii) coordination compounds with diverse dimensionalities were assembled using 3′-nitro-biphenyl-2,4,4′-tricarboxylic acid as a main building block.

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