Flexible support frame for bioprosthetic heart valves

1986 ◽  
Vol 21 (5) ◽  
pp. 626-634
Author(s):  
N. B. Dobrova ◽  
V. M. Sagalevich ◽  
L. S. Barbarash ◽  
N. N. Zavalishin ◽  
A. V. Agafonov ◽  
...  
Keyword(s):  
Heart Valves ◽  
Bioprosthetic Heart Valves ◽  
Flexible Support ◽  
Support Frame

Thrombosis of Surgical Bioprosthetic Heart Valves-Insights from Reports to International Medical Device Vigilance Systems

2017 ◽  
Vol 65 (S 01) ◽  
pp. S1-S110
Author(s):  
C. Gestrich ◽  
J.E. Klein ◽  
B. Toctam ◽  
G.D. Dürr ◽  
J.M. Sinning ◽  
...  
Keyword(s):  
Medical Device ◽  
Heart Valves ◽  
International Medical ◽  
Bioprosthetic Heart Valves

scholarly journals In Situ “Humanization” of Porcine Bioprostheses: Demonstration of Tendon Bioprostheses Conversion into Human ACL and Possible Implications for Heart Valve Bioprostheses

2021 ◽  
Vol 8 (1) ◽  
pp. 10
Author(s):  
Uri Galili ◽  
Kevin R. Stone
Keyword(s):  
Extracellular Matrix ◽  
Heart Valves ◽  
Cruciate Ligament ◽  
Anticoagulation Therapy ◽  
Young Patients ◽  
Collagen Fibers ◽  
Reconstruction Process ◽  
Bioprosthetic Heart Valves ◽  
Porcine Tissue ◽  
Anterior Cruciate

This review describes the first studies on successful conversion of porcine soft-tissue bioprostheses into viable permanently functional tissue in humans. This process includes gradual degradation of the porcine tissue, with concomitant neo-vascularization and reconstruction of the implanted bioprosthesis with human cells and extracellular matrix. Such a reconstruction process is referred to in this review as “humanization”. Humanization was achieved with porcine bone-patellar-tendon-bone (BTB), replacing torn anterior-cruciate-ligament (ACL) in patients. In addition to its possible use in orthopedic surgery, it is suggested that this humanization method should be studied as a possible mechanism for converting implanted porcine bioprosthetic heart-valves (BHV) into viable tissue valves in young patients. Presently, these patients are only implanted with mechanical heart-valves, which require constant anticoagulation therapy. The processing of porcine bioprostheses, which enables humanization, includes elimination of α-gal epitopes and partial (incomplete) crosslinking with glutaraldehyde. Studies on implantation of porcine BTB bioprostheses indicated that enzymatic elimination of α-gal epitopes prevents subsequent accelerated destruction of implanted tissues by the natural anti-Gal antibody, whereas the partial crosslinking by glutaraldehyde molecules results in their function as “speed bumps” that slow the infiltration of macrophages. Anti-non gal antibodies produced against porcine antigens in implanted bioprostheses recruit macrophages, which infiltrate at a pace that enables slow degradation of the porcine tissue, neo-vascularization, and infiltration of fibroblasts. These fibroblasts align with the porcine collagen-fibers scaffold, secrete their collagen-fibers and other extracellular-matrix (ECM) components, and gradually replace porcine tissues degraded by macrophages with autologous functional viable tissue. Porcine BTB implanted in patients completes humanization into autologous ACL within ~2 years. The similarities in cells and ECM comprising heart-valves and tendons, raises the possibility that porcine BHV undergoing a similar processing, may also undergo humanization, resulting in formation of an autologous, viable, permanently functional, non-calcifying heart-valves.

An approach to the optimization of preparation of bioprosthetic heart valves

1991 ◽  
Vol 24 (5) ◽  
pp. 331-339 ◽  
Author(s):  
Dimosthenis Mavrilas ◽  
Yannis Missirlis
Keyword(s):  
Heart Valves ◽  
Bioprosthetic Heart Valves

A Biomechanical and Microstructural Analysis of Bovine and Porcine Pericardium for Use in Bioprosthetic Heart Valves

2021 ◽  
Author(s):  
Greg Campion ◽  
Kylie Hershberger ◽  
Alix Whelan ◽  
Jack Conroy ◽  
Caitriona Lally ◽  
...  
Keyword(s):  
Heart Valves ◽  
Microstructural Analysis ◽  
Bioprosthetic Heart Valves ◽  
Porcine Pericardium

Dialdehyde pectin-crosslinked and hirudin-loaded decellularized porcine pericardium with improved matrix stability, enhanced anti-calcification and anticoagulant for bioprosthetic heart valves

2021 ◽  
Author(s):  
Mengyue Hu ◽  
Xu Peng ◽  
Yang Zhao ◽  
Xiaoshuang Yu ◽  
Can Cheng ◽  
...  
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Heart Valve Diseases ◽  
Bioprosthetic Heart Valves ◽  
Matrix Stability ◽  
Transcatheter Valve ◽  
Valve Diseases ◽  
Porcine Pericardium

To conveniently and effectively cure heart valve diseases or defects, combining with transcatheter valve technology, bioprosthetic heart valves (BHVs) originated from the decellularized porcine pericardium (D-PP) have been broadly used...

Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH

2018 ◽  
Vol 72 ◽  
pp. 196-205 ◽  
Author(s):  
Runjie Zhang ◽  
Ying Wang ◽  
Lei Chen ◽  
Ronggen Wang ◽  
Chu Li ◽  
...  
Keyword(s):  
Heart Valves ◽  
Bioprosthetic Heart Valves

Large Displacement Flexural Properties of Tissue Engineered Heart Valve Scaffolds

2000 ◽  
Author(s):  
Michael S. Sacks ◽  
Sanjay Kaushal ◽  
John E. Mayer
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Critical Test ◽  
Bioprosthetic Heart Valves ◽  
Property Evaluation ◽  
Fundamental Information ◽  
Tissue Engineered Heart Valve ◽  
Valve Prostheses ◽  
Tissue Engineered Heart Valves

Abstract The need for improved heart valve prostheses is especially critical in pediatric applications, where growth and remodeling are essential. Tissue engineered heart valves (TEHV) have functioned in the pulmonary circulation of growing lambs for up to four months [1], and thus can potentially overcome limitations of current bioprosthetic heart valves. Despite these promising results, significant questions remain. In particular, the role of scaffold mechanical properties in optimal extra-cellular matrix development, as well as TEHV durability, are largely unexplored. We have previously demonstrated flexure testing as a sensitive and critical test for BHV tissue mechanical property evaluation [2]. The following study was conducted to determine the feasibility of using this technique to provide fundamental information required for optimizing TEHV scaffold designs.

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