Chloride and sodium transport across bovine tracheal epithelium: Effects of secretagogues and indomethacin

1984 ◽  
Vol 402 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Jane E. Langridge-Smith ◽  
Mrinalini C. Rao ◽  
Michael Field
Keyword(s):  
Sodium Transport ◽  
Tracheal Epithelium

Female sex steroids modulate alveolar epithelial sodium transport

2010 ◽  
Vol 222 (S 01) ◽  
Author(s):  
M Laube ◽  
E Küppers ◽  
U Thome
Keyword(s):  
Sex Steroids ◽  
Sodium Transport ◽  
Alveolar Epithelial ◽  
Female Sex

Erythrocyte Sodium Transport, Intraplatelet pH, and Calcium Concentration in Salt-Sensitive Hypertension

Hypertension ◽  
1996 ◽  
Vol 27 (4) ◽  
pp. 919-925 ◽  
Author(s):  
María del Mar Lluch ◽  
Alejandro de la Sierra ◽  
Esteban Poch ◽  
Antonio Coca ◽  
María Teresa Aguilera ◽  
...  
Keyword(s):  
Sodium Transport ◽  
Calcium Concentration ◽  
Erythrocyte Sodium ◽  
Salt Sensitive Hypertension

Endothelin stimulates chloride secretion across canine tracheal epithelium

1991 ◽  
Vol 261 (2) ◽  
pp. L188-L194 ◽  
Author(s):  
P. I. Plews ◽  
Z. A. Abdel-Malek ◽  
C. A. Doupnik ◽  
G. D. Leikauf
Keyword(s):  
Epithelial Cells ◽  
Short Circuit ◽  
Second Messengers ◽  
Short Circuit Current ◽  
Chloride Secretion ◽  
Tracheal Epithelium ◽  
Membrane Phospholipids ◽  
Cl Secretion ◽  
Tracheal Epithelial Cells ◽  
Tracheal Epithelial

The endothelins (ET) are a group of isopeptides produced by a number of cells, including canine tracheal epithelial cells. Because these compounds are endogenous peptides that may activate eicosanoid metabolism, we investigated the effects of ET on Cl secretion in canine tracheal epithelium. Endothelin 1 (ET-1) was found to produce a dose-dependent change in short-circuit current (Isc) that increased slowly and reached a maximal value within 10-15 min. When isopeptides of ET were compared, 300 nM ET-1 and ET-2 produced comparable maximal increases in Isc, whereas ET-3 produced smaller changes in Isc (half-maximal concentrations of 2.2, 7.2, and 10.4 nM, respectively). Ionic substitution of Cl with nontransported anions, iodide and gluconate, reduced ET-1-induced changes in Isc. Furthermore, the response was inhibited by the NaCl cotransport inhibitor, furosemide. In paired tissues, ET-1 significantly increased mucosal net 36Cl flux without significant effect on 22Na flux. The increase in Isc induced by ET was diminished by pretreatment with indomethacin. The second messengers mediating the increase in Isc were investigated in cultured canine tracheal epithelial cells. ET-1 stimulated the release of [3H]arachidonate from membrane phospholipids, increased intracellular Ca2+ (occasionally producing oscillations), and increased adenosine 3',5'-cyclic monophosphate accumulation. The latter was diminished by indomethacin. Thus ET is a potent agonist of Cl secretion (with the isopeptides having the following potency: ET-1 greater than or equal to ET-2 greater than ET-3) and acts, in part, through a cyclooxygenase-dependent mechanism.

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