Phenolcarboxylic acids ofAstragalus floccosifolius

1984 ◽  
Vol 20 (4) ◽  
pp. 501-502
Author(s):  
R. K. Yasinov ◽  
N. V. Syrovezhko ◽  
G. P. Yakovlev
Keyword(s):  
Phenolcarboxylic Acids

scholarly journals Alleviation of Multidrug Resistance by Flavonoid and Non-Flavonoid Compounds in Breast, Lung, Colorectal and Prostate Cancer

2020 ◽  
Vol 21 (2) ◽  
pp. 401 ◽  
Author(s):  
Teodora Costea ◽  
Oana Cezara Vlad ◽  
Luminita-Claudia Miclea ◽  
Constanta Ganea ◽  
János Szöllősi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Multidrug Resistance ◽  
Phenolic Compounds ◽  
Epithelial To Mesenchymal Transition ◽  
Inflammatory Responses ◽  
Inhibition Of Proliferation ◽  
Mesenchymal Transition ◽  
Beneficial Effects ◽  
Different Types ◽  
Phenolcarboxylic Acids

The aim of the manuscript is to discuss the influence of plant polyphenols in overcoming multidrug resistance in four types of solid cancers (breast, colorectal, lung and prostate cancer). Effective treatment requires the use of multiple toxic chemotherapeutic drugs with different properties and targets. However, a major cause of cancer treatment failure and metastasis is the development of multidrug resistance. Potential mechanisms of multidrug resistance include increase of drug efflux, drug inactivation, detoxification mechanisms, modification of drug target, inhibition of cell death, involvement of cancer stem cells, dysregulation of miRNAs activity, epigenetic variations, imbalance of DNA damage/repair processes, tumor heterogeneity, tumor microenvironment, epithelial to mesenchymal transition and modulation of reactive oxygen species. Taking into consideration that synthetic multidrug resistance agents have failed to demonstrate significant survival benefits in patients with different types of cancer, recent research have focused on beneficial effects of natural compounds. Several phenolic compounds (flavones, phenolcarboxylic acids, ellagitannins, stilbens, lignans, curcumin, etc.) act as chemopreventive agents due to their antioxidant capacity, inhibition of proliferation, survival, angiogenesis, and metastasis, modulation of immune and inflammatory responses or inactivation of pro-carcinogens. Moreover, preclinical and clinical studies revealed that these compounds prevent multidrug resistance in cancer by modulating different pathways. Additional research is needed regarding the role of phenolic compounds in the prevention of multidrug resistance in different types of cancer.

Isotachophoretic analysis of flavonoids and phenolcarboxylic acids of relevance to phytopharmaceutical industry

1991 ◽  
Vol 559 (1-2) ◽  
pp. 499-504 ◽  
Author(s):  
Ulrike Seitz ◽  
Günther Bonn ◽  
Peter Oefner ◽  
Michael Popp
Keyword(s):  
Phenolcarboxylic Acids

scholarly journals Synthesis, Characterization, and In Vitro Cancer Cell Growth Inhibition Evaluation of Novel Phosphatidylcholines with Anisic and Veratric Acids

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2022 ◽  
Author(s):  
Marta Czarnecka ◽  
Marta Świtalska ◽  
Joanna Wietrzyk ◽  
Gabriela Maciejewska ◽  
Anna Gliszczyńska
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Organism ◽  
Cancer Cell Growth ◽  
Anticancer Properties ◽  
Health Promoting ◽  
Phenolcarboxylic Acids ◽  
Mcf 7

Phenolic acids and its methoxy derivatives are known to induce caspase-mediated apoptosis activity and exhibit cytotoxic effect towards various cancer cell lines. However, their low stability and poor bioavailability in the human organism extensively restrict the utility of this group of compounds as anticancer and health-promoting agents. In this report, a series of eight novel phosphatidylcholines (3a-b, 5a-b, 7a-b, 8a-b) containing anisic or veratric acids (1a-b) at sn-1 and/or sn-2 positions were synthesized. The phenoylated phospholipids were obtained in good yields 28–66%. The structures of novel compounds were determined by their spectroscopic data. All synthesized compounds were evaluated for their antiproliferative activity towards six cancer cell lines and normal cell line Balb/3T3. Lipophilization of phenolcarboxylic acids significantly increased their anticancer properties. The asymmetrically substituted phenoylated phosphatidylcholines exhibited higher antiproliferative effect than free acids. Lysophosphatidylcholine (7b) effectively inhibited the proliferation of human leukaemia (MV4-11), breast (MCF-7), and colon (LoVo) cancer cell lines at concentrations of 9.5–20.7 µm and was from 19 to 38-fold more active than corresponding free veratric acid. The conjugation of anisic/veratric acids with the phosphatidylcholine have proved the anticancer potential of these phenolcarboxylic acids and showed that this type of lipophilization is an effective method for the production of active biomolecules.

scholarly journals Prospects for the drug use based on common ivy for bronchopulmonary pathology in childhood

2021 ◽  
pp. 122-127
Author(s):  
Yu. L. Mizernitskiy ◽  
N. L. Dorovskaya ◽  
I. M. Melnikova
Keyword(s):  
Respiratory Infections ◽  
Inflammatory Diseases ◽  
Physical Exertion ◽  
Biologically Active ◽  
Herbal Remedies ◽  
Hedera Helix ◽  
Runny Nose ◽  
Complex Therapy ◽  
Acute Respiratory Viral Infection ◽  
Phenolcarboxylic Acids

Respiratory diseases persistently lead in the structure of general morbidity in both children and adolescents. Acute respiratory infections are the most common among them. Interest of pediatricians to phytotherapy is not accidental and is due to the fact that it has a mild therapeutic effect, enhances the effectiveness of complex therapy, has few side effects. Of particular interest are herbal remedies containing ivy extract (Hedera helix), the active ingredients are mainly found in ivy leaves, they are biologically active substances: Triterpene saponins, glycosides, also contain carbohydrates, essential oils, steroids, phenolcarboxylic acids, coumarins, flavonoids, carotenoids, tocopherols (vitamin E), B and C vitamins, tannins, phytoncides. Ivy preparations are prescribed as an expectorant in the treatment of infectious and inflammatory diseases of the upper and lower respiratory tract due to their proven multidirectional effects: secretolytic, mucolytic, bronchospasmolytic. They also have anti-inflammatory, reparative, antioxidant effects.This article presents a clinical example of an officinal ivy-based preparation used in the treatment of a 3.5 year old patient diagnosed with acute respiratory viral infection. Temperature increased to 38 °C, runny nose; on the second day of illness the temperature remained subfebrile and a dry cough appeared. Nasal vasoconstrictor drops and oral acetylcysteine were prescribed, but there was no relief. On the third day of the illness, against the background of subfebrile temperature, the cough persisted, single dry rales were heard in the lungs, wheezing appeared during physical exertion. Acetylcysteine was withdrawn and replaced by ivy-based drops (16 drops 3 times a day orally after meals in a small amount of water). After 2 days the cough was moist, the sputum was easily expectorated, the wheezing in the lungs was almost gone, there was no more wheezing and the temperature was normal. By the sixth day of treatment the cough was gone and the girl had almost recovered. Nevertheless, Gedelix was continued for another 4 days. Prospective results and detailed study of the effects of herbal preparations on the basis of ivy extracts served as the basis for their recommendation as a complex therapy of cough in children.

scholarly journals A comparative study of phenolic compound antioxidant activity by the polarography method, using microsomal lipid peroxidation in vitro

2018 ◽  
Vol 31 (4) ◽  
pp. 186-189
Author(s):  
Anatolii Gordiienko ◽  
Mykola Blazheyevskyi ◽  
Ivan Iurchenko
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Chemical Structure ◽  
Quantitative Estimation ◽  
Antioxidant Properties ◽  
Microsomal Lipid Peroxidation ◽  
Phenolcarboxylic Acids ◽  
Inhibition Ability

Abstract For comparative purposes, a quantitative estimation of antioxidant activity of phenolic compounds of different classes was conducted by way of the polarography method, via the ADP-Fe2+ model of the induced ascorbate-dependent lipid peroxidation of rat liver micro-somes within an in-vitro system. As a result, it was recognized that the antioxidant properties of phenolic compounds depend on the nature and chemical structure of several substances. In respect of such activity, leaders in the classes of investigated polyphenolic compounds are: Propyl gallate = Gallotannin (Phenolcarboxylic acids and their derivatives) > Quercetin = Myricetin (Flavonols) > Luteolin (Flavo n) = Mangiferin (Xanthones) > Kaempferol (Flavonols) = Catechin (Flavans). Thus, the assessment of the inhibition ability of the lipid peroxidation of microsomes by phenolic compounds can be used as an accessible test for the preliminary quantitative estimation of their antioxidant properties.

scholarly journals Morphological and biochemical diversity of Spiraea hypericifolia (Rosaceae) growing under natural conditions in Novosibirsk Oblast

2021 ◽  
Vol 38 ◽  
pp. 00062
Author(s):  
Vera A. Kostikova ◽  
Sheng-Xiang Yu ◽  
Mathew T. Sharples
Keyword(s):  
Phenolic Compounds ◽  
High Performance ◽  
Aqueous Ethanol ◽  
Morphological Characteristics ◽  
Plant Size ◽  
Novosibirsk Oblast ◽  
Natural Conditions ◽  
Flavonoid Aglycones ◽  
Ethanol Extracts ◽  
Phenolcarboxylic Acids

A study on some morphological characteristics and the set and levels of phenolic compounds was performed for the first time on Spiraea hypericifolia L. (Rosaceae Juss.) growing under natural conditions in the Novosibirsk region (four sites). Two phenotypic varieties of S. hypericifolia were identified. Twenty-three phenolic compounds were found in aqueous-ethanol extracts from S. hypericifolia leaves by high-performance liquid chromatography. Chlorogenic, p-hydroxybenzoic, and p-coumaric acids and quercetin, hyperoside, isoquercitrin, avicularin, rutin, and astragalin were identified among them. Hyperoside (6.7–20.5 mg/g) is the main phenolic compound in S. hypericifolia leaves. Flavonoid aglycones were prepared from the leaves by hydrochloric-acid hydrolysis of the aqueous-ethanol extracts (1:1). Three flavonol aglycones (quercetin, kaempferol, and isorhamnetin) were identified in the extract hydrolysates from S. hypericifolia leaves by chromatographic analysis. Quercetin glycosides proved to be predominant phenolic compounds in all the extract hydrolysates. A comparative analysis was performed on the levels of phenolic compounds in leaves among S. hypericifolia from the different sites and between the two varieties of S. hypericifolia. It was revealed that an increase in plant size by approximately twofold correlates with a decrease in concentrations of the identified flavonoids and phenolcarboxylic acids in S. hypericifolia leaves.

scholarly journals Investigation of the extract's composition of Viper's bugloss (Echium vulgare)

2020 ◽  
Vol 15 (1) ◽  
pp. 42-46
Author(s):  
Anna Kapusterynska ◽  
Vira Hamada ◽  
Anna Krvavych ◽  
Roksolana Konechna ◽  
Maria Kurka ◽  
...  
Keyword(s):  
Total Concentration ◽  
Maximum Yield ◽  
Analysis Data ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Flowering Plant ◽  
Active Compounds ◽  
Aerial Parts ◽  
Study Results ◽  
Phenolcarboxylic Acids

The characteristics of Viper's bugloss (Echium vulgare) plant, its pharmacological properties, and extracts’ composition are presented in this study. Results of the literature analysis, data on the biologically active compounds and areas of use of this medicinal plant are summarized. Viper's bugloss (E. vulgare) is a species of flowering plant in the borage family Boraginaceae. It is native to most of Europe as well as western and central Asia. Viper's bugloss (E. vulgare) is a plant that has been utilized as food (honey), medicine, a poison, an oil, and as a dye and tannin-producing ornamental plant. Viper's bugloss (E. vulgare) is especially rich in pyrrolizidine alkaloids, flavonoids, phenolcarboxylic acids, sterones and naphthoquinones. In traditional medicine, Viper's bugloss (E. vulgare) is utilized as exhilarant and a mood stimulant. That is why one of the possible uses of this plant is considered to be treatment of depressive states. Like most representatives of Boraginaceae family, it has been insufficiently studied. No previous work quantifying flavonoids content of aerial parts of Viper's bugloss (E. vulgare) growing in Ukraine has been presented. Continuing the studies of this species, the aqueous and ethanolic extracts from Viper's bugloss (E. vulgare) aerial parts were obtained and their phytochemical composition was investigated. For the first time, the qualitative analysis of biologically active compounds in Viper’s bugloss’s extract as well as the quantitative analysis of flavonoids by aluminum chloride spectrophotometric method are reported. The experimental results showed that the total concentration of flavonoids was 2.59% in the extract. The maximum yield of extractives was found to be 16%. The obtained research data will be used in future investigations.

Phenolcarboxylic acids from Myosotis krylovii and M. palustris

2008 ◽  
Vol 44 (5) ◽  
pp. 632-633 ◽  
Author(s):  
Yu. V. Shinkarenko ◽  
V. G. Vasil′ev
Keyword(s):  
Phenolcarboxylic Acids
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