Binding of3H-desipramine to the neuronal noradrenaline carrier of rat phaeochromocytoma cells (PC-12 cells)

1986 ◽  
Vol 334 (4) ◽  
pp. 403-411 ◽  
Author(s):  
H. B�nisch ◽  
R. Harder
Keyword(s):  
Pc 12 Cells ◽  
Neuronal Noradrenaline Carrier

Protective effect of chitooligosaccharides on hydrogen peroxide-induced PC-12 cells death by inhibition of oxidative damage

2010 ◽  
Vol 34 (8) ◽  
pp. S27-S27
Author(s):  
Xueling Dai ◽  
Ping Chang ◽  
Ke Xu ◽  
Changjun Lin ◽  
Hanchang Huang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Pc 12 Cells ◽  
Cells Death

Cytocompatibility of Carbon Nanofiber Materials for Neural Applications

2003 ◽  
Vol 774 ◽  
Author(s):  
Janice L. McKenzie ◽  
Michael C. Waid ◽  
Riyi Shi ◽  
Thomas J. Webster
Keyword(s):  
Carbon Fiber ◽  
Surface Energy ◽  
Carbon Nanofibers ◽  
Carbon Fibers ◽  
Carbon Nanofiber ◽  
Fiber Composite ◽  
Scar Tissue ◽  
Pc 12 Cells ◽  
Low Surface Energy ◽  
Poly Carbonate

AbstractSince the cytocompatibility of carbon nanofibers with respect to neural applications remains largely uninvestigated, the objective of the present in vitro study was to determine cytocompatibility properties of formulations containing carbon nanofibers. Carbon fiber substrates were prepared from four different types of carbon fibers, two with nanoscale diameters (nanophase, or less than or equal to 100 nm) and two with conventional diameters (or greater than 200 nm). Within these two categories, both a high and a low surface energy fiber were investigated and tested. Astrocytes (glial scar tissue-forming cells) and pheochromocytoma cells (PC-12; neuronal-like cells) were seeded separately onto the substrates. Results provided the first evidence that astrocytes preferentially adhered on the carbon fiber that had the largest diameter and the lowest surface energy. PC-12 cells exhibited the most neurites on the carbon fiber with nanodimensions and low surface energy. These results may indicate that PC-12 cells prefer nanoscale carbon fibers while astrocytes prefer conventional scale fibers. A composite was formed from poly-carbonate urethane and the 60 nm carbon fiber. Composite substrates were thus formed using different weight percentages of this fiber in the polymer matrix. Increased astrocyte adherence and PC-12 neurite density corresponded to decreasing amounts of the carbon nanofibers in the poly-carbonate urethane matrices. Controlling carbon fiber diameter may be an approach for increasing implant contact with neurons and decreasing scar tissue formation.

Sites of Tubulin Polymerization in PC 12 Cells

1990 ◽  
Vol 54 (4) ◽  
pp. 1258-1268 ◽  
Author(s):  
Charles H. Keith ◽  
Kathleen Blane
Keyword(s):  
Tubulin Polymerization ◽  
Pc 12 Cells

Polyethyleneimine‐mediated gene delivery into rat pheochromocytoma PC‐12 cells

2008 ◽  
Vol 2 (5) ◽  
pp. 288-295 ◽  
Author(s):  
Jung Hwa Lee ◽  
Hyun Hee Ahn ◽  
Kyung Sook Kim ◽  
Ju Young Lee ◽  
Moon Suk Kim ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Pc 12 Cells
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