Indobufen (K 3920), a new inhibitor of platelet aggregation: Effect of food on bioavailability, pharmacokinetic and pharmacodynamic study during repeated oral administration to man

1979 ◽  
Vol 15 (5) ◽  
pp. 329-333 ◽  
Author(s):  
V. Tamassia ◽  
G. Corvi ◽  
L. M. Fuccella ◽  
E. Moro ◽  
G. Tosolini ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Oral Administration ◽  
Aggregation Effect ◽  
Effect Of Food ◽  
Pharmacodynamic Study

Effect of food and a proton pump inhibitor on the pharmacokinetics of S-1 following oral administration of S-1 in patients with advanced solid tumors

2011 ◽  
Vol 69 (3) ◽  
pp. 753-761 ◽  
Author(s):  
Max E. Scheulen ◽  
Kaku Saito ◽  
Ralf A. Hilger ◽  
Bastian Mende ◽  
Christopher Zergebel ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Oral Administration ◽  
Solid Tumors ◽  
Proton Pump ◽  
Advanced Solid Tumors ◽  
Effect Of Food

DURATION OF BLEEDING FOLLOWING DENTAL EXTRACTION IN RABBITS:IN FLUENCE OF PLATELET DYSFUNCTION

1987 ◽  
Author(s):  
D Declerck ◽  
F Vinckier ◽  
J Vermylen
Keyword(s):  
Platelet Aggregation ◽  
Oral Administration ◽  
Acetylsalicylic Acid ◽  
Clinical Experience ◽  
Dental Extraction ◽  
Platelet Dysfunction ◽  
Tooth Socket ◽  
Objective Evidence ◽  
Platelet Defects ◽  
Dose Dependent

Clinical experience suggests that acetylsalicylic acid prolongs bleeding after dental extraction, but objective evidence is lacking. We have studied the influence of platelet dysfunction on haemostasis following dental extraction in rabbits. Platelet defects were induced by oral administration of acetylsalicylic acid (ASA) or ticlopidine (T). Duration of bleeding was measured in following groups of Dutch rabbits:(A) control animals (n = 32),animals who received (B) ASA 100 mg/kg/day (n = 31), (C) ASA 300 mg/kg/day (n = 12)(D) T 60 mg/kg/day (n = 8) and (E) T 125 mg/kg/day (n = 12). Inhibition of thromboxane B2-formation was more than 99% in animals receiving ASA. ADP-induced platelet aggregation was inhibited in animals receiving T. Four front teeth were extracted on day 7 and tooth socket bleeding times were determined by inspecting the wounds at 5 min intervals. Oozing sockets were counted. The figure below shows the results.It is concluded that ASA or T prolong bleeding following dental extraction in rabbits. The effect appears to be dose-dependent for T. This model may be useful for evaluating haemostatic procedures applicable to patients with platelet disorders.

scholarly journals The effect of food composition on serum testosterone levels after oral administration of Andriol�Testocaps�

2007 ◽  
Vol 0 (0) ◽  
pp. 070228041819001-???
Author(s):  
Peter G. Schnabel ◽  
Wilma Bagchus ◽  
Holger Lass ◽  
Torben Thomsen ◽  
T. B. Paul Geurts
Keyword(s):  
Oral Administration ◽  
Serum Testosterone ◽  
Food Composition ◽  
Testosterone Levels ◽  
Effect Of Food

Pharmacodynamic Study of the Oral Administration of Disopyramide

1992 ◽  
Vol 4 (1) ◽  
pp. 95-98
Author(s):  
Eiji Ino-Oka ◽  
Takashi Takahashi ◽  
Tamotsu Takishima
Keyword(s):  
Oral Administration ◽  
Pharmacodynamic Study

Platelet Aggregation - Effect of Clopidogrel (Plavix)

2005 ◽  
Vol 2005 (0129) ◽  
pp. 101276-101276
Author(s):  
J. Lazarchick
Keyword(s):  
Platelet Aggregation ◽  
Aggregation Effect

Synergistic Effect of Ginger and Nifedipine on Human Platelet Aggregation: A Study in Hypertensive Patients and Normal Volunteers

2006 ◽  
Vol 34 (04) ◽  
pp. 545-551 ◽  
Author(s):  
Haw-Yaw Young ◽  
Jung-Chun Liao ◽  
Yuan-Shiun Chang ◽  
Yen-Lin Luo ◽  
Ming-Chin Lu ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Synergistic Effect ◽  
Normal Volunteer ◽  
Hypertensive Patients ◽  
Normal Volunteers ◽  
Cerebrovascular Complication ◽  
Aggregation Effect ◽  
Human Platelet Aggregation ◽  
Human Volunteers ◽  
Normal Human

In this study, we evaluated the synergistic effect of ginger and nifedipine on anti-platelet aggregation in normal human volunteers and hypertensive patients. The results showed that the percentage of platelet aggregation induced by collagen, ADP and epinephrine in hypertensive patients was larger than that in normal volunteers. Either aspirin or ginger could potentiate the anti-platelet aggregation effect of nifedipine in normal volunteer and hypertensive patients. These results suggested that ginger and nifedipine possessed synergistic effect on anti-platelet aggregation. A combination of 1 g ginger with 10 mg nifedipine per day could be valuable for cardiovascular and cerebrovascular complication due to platelet aggregation.

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