Effect of medical grade silicone rubber on balance between human serum calcium fractions

1988 ◽  
Vol 22 (5) ◽  
pp. 132-135
Author(s):  
I. B. Rozanova ◽  
A. V. Gorshkov ◽  
V. I. Sevast'yanov
Keyword(s):  
Human Serum ◽  
Serum Calcium ◽  
Silicone Rubber ◽  
Medical Grade

In vitro re-mineralization of demineralized bone matrix in human serum

2006 ◽  
Vol 44 (1) ◽  
Author(s):  
Metin Manouchehr Eskandari ◽  
Hatice Gulcin Eskandari ◽  
Melih Aktas ◽  
Ugur Atik
Keyword(s):  
Human Serum ◽  
Serum Calcium ◽  
Inorganic Phosphate ◽  
Mineral Content ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Calcium Content ◽  
Study Groups ◽  
Phosphate Content

AbstractThe aim of this study was to develop an in vitro re-mineralization model in human serum. For this purpose a commercially produced demineralized human bone matrix (DBM) was incubated in samples of human serum pools obtained from two physiologically different groups. The first group consisted of young males and the second of older females. After incubation periods of 4 and 7days at 37°C, changes in the levels of calcium and inorganic phosphate content of the serum and DBM samples were measured. The results of the study showed that the change in mineral content of serum and DBM samples in both study groups was statistically significant. The decrease in serum calcium content and increase in DBM inorganic phosphate content were significant in the young group for longer incubation times. In the older group, both serum calcium and inorganic phosphate decreased and DBM mineral content increased for the same incubation time. When the two physiological groups were compared, statistically significant differences were identified for changes in mineral levels in both serum and the DBM samples. These data indicate that the mineral content of human serum decreases and that of DBM increases when these two materials are incubated together. These changes provide evidence for the re-mineralization of DBM. The model described here could also detect a difference in re-mineralization capability between two different groups of human sera.

Evaluation of the bacterial anti-adhesive properties of polyacrylic acid, chitosan and heparin-modified medical grade Silicone rubber substrate

2015 ◽  
Vol 22 (7) ◽  
Author(s):  
Yung-Zung Chang ◽  
Jing-Tang Lin ◽  
Adhimoorthy Prasannan ◽  
Po-Chung Chen ◽  
Chou-Yuan Ko ◽  
...  
Keyword(s):  
Silicone Rubber ◽  
Polyacrylic Acid ◽  
Adhesive Properties ◽  
Medical Grade

Intravasal injection of formed-in-place medical grade silicone rubber for vas occlusion

1995 ◽  
Vol 18 (s1) ◽  
pp. 45-52 ◽  
Author(s):  
D. M. SOEBADI ◽  
W. GARDJITO ◽  
H. J. A. MENSINK
Keyword(s):  
Silicone Rubber ◽  
Medical Grade

Filler material in medical-grade silicones

1984 ◽  
Vol 42 ◽  
pp. 392-393
Author(s):  
R. T. Greer
Keyword(s):  
Silicone Rubber ◽  
Fumed Silica ◽  
Phase Distribution ◽  
Flame Temperature ◽  
Submicroscopic Structure ◽  
Wet Process ◽  
Silicone Rubbers ◽  
Hydrolysis Of ◽  
Degree Of Reinforcement ◽  
Medical Grade

Medical-grade silicone rubber is a widely utilized biomaterial. As is the case for most rubbers, fillers are used to give additional strength to the polymer. The nature of the filler is of interest in the development, fabrication and improvement of medical devices where blood and tissue compatibility may be altered by submicroscopic structure and phase distribution. The medical-grade silicone rubbers are of two types, heat-vulcanizing and room-temperature-vulcanizing (RTV).The filler used in heat-vulcanizing types is fumed silica of a small particle size of the order of 0.03 µm and smaller (0.007 µm; 0.012 µm; Cab-0-Sil®, Cabot Corp., Boston, MA 02110). It is made by a vapor phase process (hydrolysis of silicone tetrachloride at 1100° C ), producing a colloidal amorphous silica (SiO2). It is generally classified as a fumed silica due to its production at a high flame temperature. Fume-process silicas give the highest degree of reinforcement of silicone rubber compared with finely divided silicas made by a wet process (aerogels), or with diatomaceous earth.

Cylindrical Cochlear Electrode Array for Use in Humans

1989 ◽  
Vol 98 (6) ◽  
pp. 466-471 ◽  
Author(s):  
Patrick D. van der Puije ◽  
Carlos R. Pon ◽  
Hugh Robillard
Keyword(s):  
Silicone Rubber ◽  
Electrode Array ◽  
Planar Surface ◽  
Polyimide Substrate ◽  
In Vivo Tests ◽  
Multichannel Electrode ◽  
Medical Grade

This report describes the fabrication of a flexible multichannel electrode array suitable for use in humans. The conductors, pads, and stimulating tips are made of platinum on a polyimide substrate. Photolithographic techniques are employed in the fabrication of the electrode on a planar surface in the form of a film. The film is rolled subsequently into a cylinder of diameter 0.50 mm and the cylinder is filled with medical grade silicone rubber. The stimulation pads then form rings around the cylinder. In vitro and in vivo tests are ongoing with good results so far.

Evaluation of a solid-phase enzyme immunoassay for insulin in human serum.

1979 ◽  
Vol 25 (7) ◽  
pp. 1306-1308 ◽  
Author(s):  
K Kato ◽  
Y Umeda ◽  
F Suzuki ◽  
D Hayashi ◽  
A Kosaka
Keyword(s):  
Human Serum ◽  
Enzyme Immunoassay ◽  
Human Insulin ◽  
Silicone Rubber ◽  
Solid Phase ◽  
Serum Samples ◽  
Serum Factors ◽  
Insulin In Serum ◽  
Coefficients Of Variation ◽  
Sandwich Type

Abstract We describe a "sandwich-type" enzyme immunoassay for insulin in serum, in which antibody Fab'-beta-D-galactosidase conjugate and an antibody-immobilized silicone rubber solid-phase are used. The interference by serum factors with the solid-phase enzyme immunoassay can now be removed by using a buffer containing gelatin. Serum samples of 50 microL can be analyzed by the enzyme immunoassay, which is as sensitive as radioimmunoassay for human insulin. Our results correlate well with those for radioimmunoassay (r = 0.97, slope = 0.92, y-intercept = 4.6 milli-int. units /L for 181 samples). Between-assay and within-assay coefficients of variation are less than 15% over the useful ranges of the assay (5--160 milli-int. units/L).

Biodeterioration of medical-grade silicone rubber used for voice prostheses: a SEM study

Biomaterials ◽  
1993 ◽  
Vol 14 (6) ◽  
pp. 459-464 ◽  
Author(s):  
T.R Neu ◽  
H.C Van der Mei ◽  
H.J Busscher ◽  
F Dijk ◽  
G.J Verkerke
Keyword(s):  
Silicone Rubber ◽  
Voice Prostheses ◽  
Sem Study ◽  
Medical Grade
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