High dose intravenous methylprednisolone ?pulse? therapy in patients with rheumatoid disease

1982 ◽  
Vol 21 (5) ◽  
pp. 385-388 ◽  
Author(s):  
E. M. Baylis ◽  
I. A. Williams ◽  
J. English ◽  
V. Marks ◽  
J. Chakraborty
Keyword(s):  
Pulse Therapy ◽  
Methylprednisolone Pulse Therapy ◽  
High Dose ◽  
Rheumatoid Disease ◽  
Intravenous Methylprednisolone ◽  
Methylprednisolone Pulse ◽  
Intravenous Methylprednisolone Pulse

High-dose intravenous methylprednisolone pulse therapy in systemic lupus erythematosus

1981 ◽  
Vol 70 (4) ◽  
pp. 817-824 ◽  
Author(s):  
Robert P. Kimberly ◽  
Michael D. Lockshin ◽  
Raymond L. Sherman ◽  
J.Steven McDougal ◽  
Robert D. Inman ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Pulse Therapy ◽  
Methylprednisolone Pulse Therapy ◽  
High Dose ◽  
Systemic Lupus ◽  
Intravenous Methylprednisolone ◽  
Methylprednisolone Pulse ◽  
Intravenous Methylprednisolone Pulse

Treatment of Graves' ophthalmopathy with high-dose intravenous methylprednisolone pulse therapy

1987 ◽  
Vol 116 (4) ◽  
pp. 513-518 ◽  
Author(s):  
Yuji Nagayama ◽  
Motomori Izumi ◽  
Takeshi Kiriyama ◽  
Naokata Yokoyama ◽  
Shigeki Morita ◽  
...  
Keyword(s):  
Sodium Succinate ◽  
Total Duration ◽  
Pulse Therapy ◽  
Methylprednisolone Pulse Therapy ◽  
High Dose ◽  
Methylprednisolone Pulse ◽  
Methylprednisolone Sodium Succinate ◽  
Graves Ophthalmopathy ◽  
Preliminary Study ◽  
Intravenous Methylprednisolone Pulse

Abstract. This preliminary study was undertaken to investigate the efficacy of high-dose iv methylprednisolone pulse therapy in 5 patients with Graves' ophthalmopathy. One gram of methylprednisolone sodium succinate was given iv daily for 3 successive days. The 3-day infusion was repeated 3 to 7 times at intervals of 1 week; total duration of pulse therapy was 3 to 7 weeks. The clinical improvement of eye involvements by pulse therapy was assessed immediately after the last pulse therapy. The clinical assessment of the effect of pulse therapy for Graves' ophthalmopathy showed a good response in 3 patients, a fair response in one, and no response in one. However, in one patient, who was judged to show no response, complete improvement of the enlarged extraocular muscle was observed on orbital computed tomography. Moreover, two patients, who have been followed without any other therapies, showed no relapse of eye involvements for 32 and 10 months, respectively. Although it is impossible to determine whether pulse therapy is more effective than other immunosuppressive therapies, the results of this preliminary study suggest that pulse therapy may be a good immunosuppressive therapy for Graves' ophthalmopathy too. Controlled studies are desired.

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